The study objective is the analysis of major steps in Type V allergic reaction development. Certain deceases with this type of reaction have been described.

The course of pregnancy and its outcomes in 100 women with gestational diabetes mellitus diagnosed on the basis of modern criteria have been analyzed. The first group consisted of 39 pregnant women whose gestational diabetes mellitus was diagnosed before a 24-week pregnancy term, the second group included 61 pregnant patients with gestational diabetes mellitus identified after a 24-week term. The overweight baby occurrence rate (over 90 percentile) is statistically higher for the Group 1 mothers (51.3 %) compared to Group 2 (21.3 %, p < 0.01). The same is true for the number of babies belonging to 3^rd health category (17.9 % and 4.9 %, respectively). The analysis facilitates an optimal approach to monitoring pregnancy in such patients.

The paper studies the development of acute surgical diseases in 421 patients (318 males, 103 females) with terminal HIV in 2010 to 2016 and proposes an approach to selecting the appropriate surgical treatment. Multispiral computed tomography (MSCT) and magnetic resonance imaging (MRI) have been used to identify local and general mixed pathologies. Data analysis for the acute surgical disease cases in patients with terminal HIV have enabled to propose the therapeutic approach for such patients.

The study objective is the investigation of premature infant care with extremely low birth weight and bowel obstruction with an X-ray monitoring algorithm, and selecting the best surgical aid strategy. The study took place in 2009-2014 (6 years) and 2015-2016 (23 months); a blind retrospective analysis has been performed with the authors’ data and the data for two groups of extremely premature newborns (17 and 64 infants), similar in their anthropometric, clinical properties, and the number of surgeries. An optimal surgical strategy choice for the second group has reduced the mortality rate in extremely premature newborns by 80 % (from 17.6 % to 3.7 % and enable enteral feeding and further care.

The clinical efficiency of synthetic vitamin D substitute and its effects on blood calcium level as applied to the therapy of long-lasting, extensive, toprid psoriasis resistant to previous therapy has been studied. 18 psoriasis patients have been monitored. They have extensive psoriasis affecting over 50 % of the skin. The clinical effect was achieved after 7 days of the medication therapy: the papulas and spots became flat and discolored with no skin flaking; after 3 weeks the eruptions significantly reduced. Total blood calcium during and after the therapy was maintained at 1.6 mmol/l.

The study considers acute myocardial infarction therapy complicated with stent thrombosis after stent angioplasty. Inherent platelet reactivity assessed with adenosinediphosphateа is a good predictor of stent thrombosis in patients receiving clopidogrel after stent angioplasty. Genetic profiling has identified CYP 2 C 19*1/*2 genotype in patient K; clopidogrel has been replaced with ticagrelor and aspirin. A year after recurrent stent angioplasty there are no angina attacks; follow-up coronarography shows that the stents in the coronary vessels are open.

The study objective is the investigation of modern references concerning congenital genetic systems anticoagulation, procoagulation and fibrinolysis that contribute to the development of thrombosis in humans. The authors consider thrombophilia as one of the evolutionarily inherited characters. The three components of biochemical factors involved in clotting are represented. Thrombophilia is divided into "strong", "moderate" and "mild". The paper also covers the rationale and basic principles of the STOPTHROMB virtual clinic.

A retrospective analysis of the wide-spread X-ray images of the lower face zone examination is presented in order to study its ability to detect carotid artery calcifications in patients over 55 years old (mean age: 65.8 years). It should become a promising screening trend which will help reducing the risk of atherosclerotic cerebrovascular complications.

The study objective is the investigation of external respiration’s functional properties in the military personnel deployed in Russia’s Arctic region, during polar day and polar night. It has been found that in polar night (compared to polar day) the vital lung capacity in military persons increases; the relations between the vital capacity components are changed; the static lung capacity, and the lung performance are also changed: the oxygen utilization ratio significantly rises (р = 0.003), as well as the oxygen supply by one respiration cycle (р = 0.002) and one heart beat (р = 0.005).

The study objective is the investigation and optimization of intestinal bacterial community assessment in patients suffering from disorders accompanied by intestinal dysbiosis. An ecological assessment of bacterial communities in intestinal dysbiosis is given. A law of increasing the ecological gap between two communities has been identified: the E. coli density variation indicates the first signs of disparity. It may govern the sequence of intestinal microflora disorder therapy.

The study objective is the investigation of pharmacological and economic efficiency for different antibiotic therapies of herniatomy complications; two patent groups exposed to different therapies have been involved. The total cost of an ampicillin/sulbactam regimen is 4 487.9 RUB per patient; a cefazolin regimen costs 5 548.0 RUB per patient. The analysis has shown that the ampicillin/sulbactam regimen is more feasible than cefazolin in treating herniatomy complications.

The study objective is the investigation of cyctogensis occurrence rate in chronic gastric mucosa disorders. Clinical study data have been analyzed; morphological examination of gastric biopsy specimens and surgery tissues taken from patients with chronic atrophic gastritis (CAG, Group 1) and gastric cancer (GC, Group 2) have been performed and associated with systemic undifferentiated connective tissue dysplasia (CTD); the control group has included patients with the same disorder but with no CTD signs (Group 3 and 4). It is shown that cyctoenesis in various organs occurs only in CTD patients (Group 1 and 2) with a statistically significant difference from the control groups. In the GC groups it is associated with a higher intestinal metaplasia and dysplasia occurrence rate. It leads to the conclusion that cyctogenesis can be considered as one of markers or the primary epithelial-stromal relation disorder phenotype.

The study objective is the investigation of antibacterial and antimycotic properties in granular carbon adsorbents modified with oligomers of lactic and glycolic as applied to towards pathogenic and opportunistic-pathogenic microorganisms. It has been found that S. aureus, S. epidermidis, S. agalactiae, E. faecalis, P. aeruginosa, S. pyogenes , K. pneumoniae и E. coli are resistant to most antimicrobials used for treatment of bacterial and fungal infectious diseases. Noted It has also been found that the VNIITU-1 carbon sorbent has no antibacterial activity against strains of microorganisms under examination, while VNIITU-1 modified with oligomer of lactic or glycolic acid has a pronounced antibacterial activity against most microorganisms studied.