Surgical methods of small saphenous vein reflux elimination, such as endovenous laser ablation or phlebectomy are quite difficult due to numerous anastomoses with the superficial and deep venous networks. The complexity of the small saphenous veinsurgery, performed by surgeons, including sclerotherapy, phlebectomy and endovenous laser ablation, making knowledge of variant anatomy of the small saphenous vein increasingly important.

For the purpose of analgesia rise in intraoperative period and postoperative period of obstetric operations, we analyzed the influence of subhypnotic doses of ketamine in combination with the transverse abdominal muscles blockade. The first group used epidural lidocaine 200 mg and 100 mg of ropivacaine. In the second group 200 mg of lidocaine and morphine 4 mg. In the third group 400 mg of lidocaine and fentanyl 0.1 mg with ketamine 0.5 mg/kg/hour were used. Postoperatively transverse abdominal muscles blockade was undertaken for all groups. The using of subhypnotic doses of ketamine allows us to do more qualitative anesthesia with better tolerability and significantly lower incidence of side effects.

In the article the main stages of formation and development type III reactions are analyzed. The characteristic of some diseases, which have this type of reaction, is given.

In the article a clinical case of pregnancy with benign tumors is extremely rare retroperitoneal localization is presented. In the literature review current understanding of retroperitoneal leiomyoma localization, modern methods of differential diagnosis and treatment are highlighted.

Development of the medicament on the basis of human angiogenin is innovative, because at the moment there are no angiogenin medications based drugs in the pharmaceutical market. Pilot batch of the recombinant human angiogenin in gel dosage form for external application was synthesized and certified for clinical trials (original medicament "Farmagen"). First phase clinical trials of "Farmagen" medicament was conducted on 28 healthy volunteers. Results of the first phase clinical trials showed safety for external application and high degree of tolerability of "Farmagen". Pharmacokinetics of "Farmagen" for external use was investigated and it was found that when applied to an intact skin surface in healthy volunteers the bioavailability of angiogeninis absent.

Myocardial infarction and acute coronary insufficiency, which pre-neoplastic stage of ischemic myocardium, the nature of structural changes in different parts of the conduction system is diverse and is characterized by an increase in the proportion of fat and connective tissue and a decrease in the proportion of conductive cardiomyocytes.

The prevalence of diabetic foot syndrome is 4-10 % in different countries. The aim of this work is to study clinical and epidemiological features of diabetic foot syndrome in conditions of northern territories. In the total number of patients group with diabetes mellitus type 1 and 2 risk of diabetic foot syndrome developing accounted for 21 % of patients, 11 % of patients with a high risk group. The diabetic foot syndrome was diagnosed in 4.1 % of the total number of patients with diabetes mellitus.

The purpose of this study was to assess differences in eating behaviour in preschool children with different body mass. The study included 342 children from 1 to 7 years, who were divided into 3 groups: healthy children (normal weight), overweight and children wigh obesity. Significant differences were obtained in eating behaviour of preschool children with normal body weight and obesity on such aspects of nutrition as response saturation, response to food, emotional overeating

The research study of boys and girls, residents of the KhMAO - Ugra territory, diagnosed with syndrome of undifferentiated connective tissue dysplasia the high prevalence rate of connective tissue dysplasia has been found and its somatotopic peculiarities have been identified. A statistically significant negative relation between the occurrence of diagnostically significant criteria of undifferentiated connective tissue with body mass (r = -0.66; p = 0.009), fat content (r = -0.58; p = 0.01) and Brugsсh index (r = -0.53; p = 0.0001) has been identified, which can indicate that these values decrease as the phenotypic markers of connective tissue dysplasia accumulate.

The peculiarity of modern clinical flow of infective endocarditis in the urbanized North Surgut City, as exemplified by 74 pathology cases, were studied. Significant clinical diagnostic differences of infective endocarditis of left and right heart chamber were found. It is shown that intravenous narcomania has critical importance in aetiology of dextral infective endocarditis, followed by infecting persons with HCV and HIV. The characteristics of infective endocarditis of right heart chamber give the ground to separate it to a separate clinical form.

The concept of risk factors in recent decades has become the basis for the prevention of cardiovascular diseases; the relevance of studying the issue persists due to the high rate of mortality from diseases of the circulatory system. There are statutory and non-cconventional or psychosocial risk factors. The contribution of nonconventional risk factors in the development of cardiovascular disease is undeniable. We investigate the association of psychosocial factors with the severity of acute coronary syndrome patients who live in the North.

One of the main reasons for the growth of tuberculosis worldwide is the epidemic of HIV infection. Tuberculosis went from the third to the first position among the complications of AIDS and took a leading place among the causes of death among HIV-infected patients. Severe manifestations of HIV and tuberculosis are caused by defects in cellular immunity in both diseases, contributing to the development of opportunistic infections, which significantly reduce the life expectancy of patients. With the increasing incidence of tuberculosis and HIV infection actually stands a problem of studying the dual TB/HIV-infection.

The study objective is investigating the surgical approach to an opisthorchiasis papillitis at various decease development stages. Opisthorchiasis is endemic to Ugra, Khanty-Mansi Autonomous Okrug. The research has revealed that 100 % of the patients with case history up to 6 years develop papillitis stage I; for up to 15 years long case history 87.7 % of patients develop stage II papillitis; stage III has been diagnosed in patients with case history over 15 years. A treatment strategy matching the disease stage has been proposed: for I stage patients: conservative treatment, for II stage patients: balloon dilatation, for III stage patients: endoscopic papillosphincterotomy or biliodigestive anastomosis.

By refractory glaucoma the traditional fistulising surgery is incapable of fast cicatrisation of surgically made outflow tracts of intraocular fluid. For reduction of the cicatrisation processes and aqueous humor outflow relief drainages are applied. The first experience of valvar drainage Ahmed is analyzed in surgical obstinate glaucoma. The Enthesis of valvar drainage Ahmed is an effective method of surgical treatment of obstinate glaucoma, which allows to achieve recovery intraocular tension.

The analysis of the case histories of 1057 patients with acute stroke was made with the purpose to assess epidemiological surveillance and treatment outcomes, aimed at improving the provision of care to patients with stroke.