CLINICAL CASE OF A LONG-TERM UNDIAGNOSED NECROBIOSIS LIPOIDICA WITH ENDOCRINE PATHOLOGY

The study aims to present the clinical case of a long-term undiagnosed necrobiosis lipodica in a patient with endocrine pathology to discuss the clinical and morphological picture of the disease, as well as its differential diagnosis. Material and methods. A 48 years old man made complaint on changes of the skin on his left shin, which occurred about 10 years ago. Earlier, the dermatologist diagnosed it as psoriasis, the prescribed treatment was not effective. With anamnesis collected, it was found that the patient has undergone substitutive therapy for
hypogonadism for a long period. The examination of lesion led to suggestion of diagnosis “necrobiosis lipoidica”. Results. In the course of diagnostic actions, the diagnosis “necrobiosis lipodica” was confirmed. The presented clinical case shows the significance of thorough differential diagnosis of diseases in patients with background pathologies of endocrine system.

1. Erfurt-Berge C., Seitz A.-T., Rehse C., Wollina U., Schwede K., Renner R. Update on Clinical and Laboratory Features in Necrobiosis Lipoidica: A Retrospective Multicentre Study of 52 Patients // Eur J Dermatol. 2012. Vol. 22, No. 6. P. 770–775.

2. Теплюк Н. П., Шимановский Н. Л., Варшавский В. А., Королёва В. С. Перспективные направления в изучении патогенеза липоидного некробиоза // Рос. журнал кожных и венерических болезней. Т. 23, № 1. 2020. С. 23–28.

3. Смирнова Л. М., Семенчак Ю. А., Панченко Л. А. Липоидный некробиоз: обзорная статья // Рос. журнал кожных и венерических болезней. 2018. Т. 21, № 1. С. 40–44.

4. Lepe K., Riley C. A., Salazar F. J. Necrobiosis Lipoidica. Treasure Island : StatPearls, 2021.

5. Петунина Н. А., Трухина Л. В., Мартиросян Н. С., Петунина В. В. Поражения различных органов и систем при гипотиреозе // Эффективная фармакотерапия. 2016. № 4. С. 40–44.

6. Jockenhöfer F., Kröger K., Klode J., Renner R., Erfurt-Berge C., Dissemond J. Cofactors and Comorbidities of Necrobiosis Lipoidica: Analysis of the German DRG Data From 2012 // J Dtsch Dermatol Ges. 2016. Vol. 14, Is. 3. P. 277–284. DOI 10.1111/ddg.12749.

7. Peyrí J., Moreno A., Marcoval J. Necrobiosis Lipoidica // Semin Cutan Med Surg. 2007. Vol. 26, Is. 2. P. 87–89. DOI 10.1016/j.sder. 2007.02.004.

8. Gebauer K., Armstrong M. Koebner Phenomenon with Necrobiosis Lipoidica Diabeticorum // Int J Dermatol. 1993. Vol. 32, Is. 12. P. 895–896.