LOCAL CHANGES REGRESSION IN MAGNETIC RESONANCE IMAGE OF BONE MARROW TISSUE AFTER INTRAOSSEOUS THERAPY: A CLINICAL FOLLOW-UP

Intraosseous drug administration has been practiced in medicine for nearly a century. Initially, intraosseous access was an option for administering anesthetic medications, blood loss replacement, and diagnostics. Nevertheless, since 1953, researchers have focused on substantiating the efficacy of intraosseous infusion in disease treatment. The creation of magnetic resonance imaging (MRI) made it possible for doctors who applied intraosseous access to observe changes in bone marrow tissue post-procedure. This could serve as a reason to refuse the therapy under consideration. Modern medical science lacks studies that would justify the safety of intraosseous infusion as well as demonstrate postoperative regeneration or degeneration of bone marrow tissue. The purpose of the paper is to present a clinical follow-up of reversible bone marrow changes after an intraosseous infusion course based on MRI scans. The article describes a case of tendinosis affecting the right flexor digitorum superficialis tendons. Following the treatment that incorporated Professor Evgenii L. Sokov's method, the patient underwent an MRI of the injection area. Final scanning was conducted 3 months after the therapy. Upon course completion, the research identified reactive changes in bone marrow tissue, i.e. tissue heterogeneity associated with inflammation. Still, the authors highlight the regression of the detected changes in the specified area 3 months post-treatment. Intraosseous drug administration is a safe therapeutic approach. Its efficacy is achieved through both the selected medication and established osteogenetic mechanisms addressed in the scientific works of G. A. Yankovsky, E. L. Sokov, L. E. Kornilova, and their followers. Caused by intraosseous infusions, the changes in bone marrow tissue are reversible and innocuous, which is confirmed by histological and clinical data and the presented clinical follow-up using MRI.

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