ASSESSING SYNERGY OF HEMOSTASIS AND FOLATE METABOLISM GENETIC FACTORS IN PREGNANCY COMPLICATIONS DEVELOPMENT
https://doi.org/10.35266/2949-3447-2026-2-4
Abstract
The research assesses how genetic polymorphisms of hemostasis and folate metabolism affect the great obstetrical syndromes development. The article is devoted to identifying the correlation between the pathology’s genetic polymorphisms and clinical manifestations. The investigation involves 248 pregnant women divided into a group having the specified syndromes (n = 129) and a control group (n = 119). Here, genotyping comprises 12 polymorphic loci associated with hemostasis and folate metabolism. The analysis of the allele frequency distribution reveals no profound differences between the groups. However, the relative risk evaluation demonstrates a connection between polymorphic gene variants, which are responsible for coagulation, platelet receptors, and folate cycle enzymes, and an increased possibility of the great obstetrical syndromes’ progression. Using multifactor dimensionality reduction, the authors designed a model of the synergetic relation between polymorphisms F13, SERPINE1, and MTHFR, which increase the obstetrical pathology risk. The findings show the complexity of genetic disposition to the great obstetrical syndromes. Further investigation is required to develop a prediction model that would integrate both genetic and clinical risk factors.
About the Authors
A. Kh. Gapurova
Surgut State University, Surgut
Russian Federation
Russian Federation
Junior Researcher
A. V. Morozkina
Surgut State University, Surgut
Russian Federation
Russian Federation
Candidate of Sciences (Biology), Docent, Leading Researcher
M. L. Safronova
Surgut State University, Surgut
Russian Federation
Russian Federation
Junior Researcher
М. Yu. Donnikov
Surgut State University, Surgut
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Leading Researcher
L. V. Kovalenko
Surgut State University, Surgut
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor
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Review
For citations:
Gapurova A.Kh., Morozkina A.V., Safronova M.L., Donnikov М.Yu., Kovalenko L.V. ASSESSING SYNERGY OF HEMOSTASIS AND FOLATE METABOLISM GENETIC FACTORS IN PREGNANCY COMPLICATIONS DEVELOPMENT. Vestnik SurGU. Meditsina. 2026;19(2):33-41. (In Russ.) https://doi.org/10.35266/2949-3447-2026-2-4
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