The study aims to analyze the scientific literature from eLIBRARY.RU, PubMed, and Wiley on dermatitis progression, pathogenesis, clinical image, and diagnosis techniques. Furthermore, the study focuses on the severity of the disease course affected by genetic processes of progression, skin microbiological content, immunological alterations, skin barrier integrity, and the neurological system. Patient management for those diagnosed with atopic
dermatitis is associated with the type of skin lesions and disease progress and performed with advanced high-precision neural network technologies aimed at disease diagnosis and prediction.

The study aims to review and analyze modern methods for diagnosing intra-articular fractures described in scientific literature from PubMed and eLIBRARY.RU. Intra-articular fractures can lead to a higher risk of disability and severe life quality damage. Therefore, in addition to traditional methods of diagnosis, standard X-ray methods, ultrasound diagnosis, magnetic resonance imaging, and computer tomography are commonly used in modern medicine for detailed assessment of fracture dislocation.

The study aims to review an up-to-date state of the cardiovascular complications manifested as acute cerebral circulation disorders, as well as the issues of medical rehabilitation with physical therapy technologies for patients with concomitant metabolically associated pathology in acute stage. The review was based on the scientific publications and regulatory legal acts from eLIBRARY.RU, PubMed, and Google Scholar. The search depth was 20 years. Comorbidity and its role in etiopathogenesis and frequency of cardiovascular events in a form of acute cerebral circulation disorders, which caused along with ischemic disorder mortality in Russia and worldwide, was analyzed. The possibilities of physic therapy technologies application during the first medical rehabilitation stage were determined.

The study aims to assess the risks for preeclampsia progression in pregnant women with SARS-CoV-2 based on the study obtained in 2021, which included the pregnancy course and outcome of 1 122 women divided into three groups. The groups were as following: 52 pregnant women with positive SARS-CoV-2 and preeclampsia, 302 women with negative SARS-CoV-2 and preeclampsia, and 768 pregnant women with positive SARS-CoV-2 and without preeclampsia. Chronic arterial hypertension prevailed in women with positive SARS-CoV-2 and preeclampsia by 2.5 times in comparison with those with negative SARS-CoV-2 and preeclampsia, and by 10.4 times in comparison with those with positive SARS-CoV-2 and without preeclampsia. Assisted reproductive technologies were used for pregnant women with positive SARS-CoV-2 and preeclampsia 7.9 and 11.8 times more frequently than for other groups of women. Women with preeclampsia suffered from premature birth, premature detachment of the placenta, cesarean delivery, and asphyxia of newborns at a higher rate.

The study aims to evaluate risk factors for complicated pregnancy courses based on the retrospective analysis of 510 anamneses from 2014 to 2021, as well as singleton and multiple pregnancies outcomes with and without preeclampsia registered in the Surgut District Clinical Center for Maternal and Child Health. The study states that chronic arterial hypertension, obesity, hypothyroidism, and preeclampsia in anamnesis may result in preeclampsia in singleton pregnancy, while its manifestation is associated with the worst neonatal outcomes and a more apparent multiple organ dysfunction syndrome. In multiple pregnancy, assisted reproductive techniques
were a significant risk factor for preeclampsia. However, the pathological process demonstrated a moderate type of early preeclampsia and was not associated with unfavorable perinatal outcomes.

The study aims to determine the anamnestic, functional, and laboratory factors affecting the load of basic drug therapy in children with bronchial asthma during a ten-year regular dynamic monitoring of their height,
body weight, spirometry data, the nature of the ongoing treatment of asthma, and the drug doses. An open, prospective monitoring trial included 131 patients, each of whom attended a hospital at least 20 times every 6 months.
The data obtained was not used to correct the therapy method and regular medical check-up. By the end of the tenth year, 98 patients had demonstrated the following results: 57.1 % of children maintained a stable load of basic
therapy, while the load of drug therapy was increased in 24.5 % of patients, and decreased in 18.4 % of them. The likelihood of a drug load reduction was statistically significantly reduced in patients with a body mass index greater than 90 weight percentile for 18 months or longer in comparison with patients who had never been overweight. Patients with the obstructive disorders detected with spirometry during two or more consecutive visits had
a statistically significantly higher risk of drug therapy overload or a lower likelihood of its reduction in comparison with those without any external respiration malfunctions. The allergen-specific therapy made it possible to significantly lower the risk of drug overload and increase the possibility of its reduction. The allergen-specific immunotherapy, body weight management, and absence of obstructive disorders in spirometry all contribute to reducing
the drug therapy load while maintaining a controlled course of the disease.

The study aims to evaluate the dynamics of primary morbidity, mortality, and disability indicators in the adult population affected by cerebrovascular diseases in the Tyumen region (without autonomous districts) and in the Russian Federation. A continuous statistical observation was conducted using direct ranking method and time series evaluation. The study of key disease demographic data in the Tyumen region and the Russian Federation from 2011 to 2021 demonstrates that novel coronavirus infection impacted the primary morbidity, mortality, and disability indicators of cerebrovascular diseases in adult population. The year 2020 is acknowledged as challenging
to assess due to considerable instability in the Russian healthcare system. First, there is intersection of patients, limitation and total absence of medical care, preventive check-ups, and the annual health examination at the
beginning of COVID-19 spread. In terms of primary morbidity, mortality, and disability of cerebrovascular diseases, the Tyumen region demonstrates more stable indicators in comparison to the Russian Federation.

The study aims to assess empagliflozin affecting ventricular dysrhythmia and late potential of ventricles in patients with chronic heart failure with low etiology ejection fraction. The study included 35 male patients (61.7 ± 11.2 years old) who received standard therapy, followed by 10 mg empagliflozin in 6 months. The examination included echocardioscopy, 12-leads electrocardiography, signal-averaged electrocardiography, and daily electrocardiography monitoring. 10 mg empagliflozin added to the standard therapy provided for a statistically significant decrease in the number of single premature heart beats by 67.7 % (p = 0.001), in the episodes of unstable ventricular tachycardia by 74.5 % (p = 0.001), in the frequency of late ventricular potential by 31 % (Chisquare = 5.51; р = 0.019), and for a statistically insignificant trend to ejection fraction increase (p > 0.05).

The study aims to describe a structure and functions of an information module database of biological samples associated information (blood and its components, genome DNA) for the biobank of the Medical Institute at Surgut State University.

The study aims to determine features of the emotional state, to assess the severity of depression and anxiety symptoms in military personnel who undergo military service under extreme climate conditions, to detect the association between gene polymorphisms, and to identify their most favorable combination. The L. A. Kurgansky and T. A. Nemchin method was used to assess the stress level; the hospital anxiety and depression scale was used to assess the level of anxiety and depression; the level of personality neuroticism was assessed with the express diagnosis scale developed by the staff at the V. M. Bekhterev State Medical Research Center of Psychiatry and Neurology. Real-time genotyping of servicemen’s genome DNA samples was carried out on a DTprime amplifier. One-way analysis of variance assessed the significance of differences in mean values of qualitative indicators with a normal distribution between three independent groups. The Kraskel-Wallis test assessed variables, whose distribution differed from normal. The assessment of independent factors affecting dependent binary groups was conducted with logistic regression. With more than two groups, assessment was conducted with polynomial logistic regression. The results are demonstrated as a relation of chances with a 95 % confidence interval. Poisson regression was used for discrete variables, with results demonstrated as a related risk with a 95 % confidence interval. The method of psychological and psychiatric screening allowed determining the prevalence of an average level of emotional well-being of military personnel who undergo military service in Arctic zone, as well as their genotypes suitable for such service: genotype T/T of the ACTN3 gene (rs1815739), genotype C/C of the HIF1A gene (rs11549465), genotype T/T of the LIPC gene (rs1532085), and genotype G/G of the BDNF gene (rs6265).

The study aims to detect the effects of non-inhaled anesthetics of two different types on the parameters of the central hemodynamics and microcirculation in an occlusive reactive hyperemia test in two groups of male Wistar rats weighting 400–500 g. The “ChH” group received 6 % chloral hydrate solution at a dose of 300 mg/kg intraperitoneally, while the “zol + xyl” group received 20 mg/kg of tiletamine/zolazepam (Zoletil 100, France) mixed with 5 mg/kg of xylazine (Xylanit, Russia) intraperitoneally. The following parameters were measured: blood pressure, average heart rate, duration of PQ, QRS, and QTc intervals according to the electrocardiography, cutaneous blood flow with laser Doppler flowmetry, arterial blood gas composition and acid-base state. The mean value of perfusion was recorded simultaneously with electrocardiography and blood pressure. The parameters of a
post-occlusive reactive hyperemia were analyzed to conduct an occlusive reactive hyperemia test. Blood pressure was statistically significantly lower in “ChH” group than in “zol + xyl” group when analyzing the central hemodynamics parameters. The “ChH” group demonstrated higher maximum vasodilation in reactive hyperemia (CVCmax) and time of its achievement (Tmax). Both types of anesthesia demonstrated compensated and subcompensated mixed acidosis and moderate arterial hypoxemia when comparing parameters of arterial blood gas composition and acid-base state in rats.

The study aims to conduct a transcranial electrical stimulation therapy trial in rats influencing the indicators of systemic inflammation dynamics and the percentage content of visceral adipose tissue in a highfat fructose diet. The study included 180 male outbred rats, which were randomly distributed into three groups: the first group had a standard diet; the second group received the high-fat fructose diet; and the third group received both transcranial electrical stimulation therapy and the high-fat fructose diet. Tumor necrosis factor-α, interleukin-15, and interleukin-19 concentrations were measured in blood serum. The percentage of visceral adipose tissue in relation to body weight was calculated. The percentage content of visceral adipose tissue and serum concentration of tumor necrosis factor-α were lower, and interleukin-19 was higher in rats that received transcranial electrical stimulation with a high-fat fructose diet in comparison to the second group, which did not undergo the stimulation. Interleukin-19 level in the blood serum of rats in the second group grew as the trial progressed, whereas the opposite occurred in the third group. There was an inverse relation between the predictive variables of transcranial electrical stimulation, interleukin-19, and the variable of tumor necrosis factor-α. The data obtained in the experiment may also indicate that interleukin-15 cannot be unequivocally considered as a key factor associated with a decrease in visceral adipose tissue content when introducing a high fructose and animal-based
saturated fat diet to rats.