The goal of the article is to establish the relationship between indicators of the structure and function of the left ventricle in patients who have endured a myocardial infarction with ST-segment elevation. We examined the left ventricle during its post-infarction remodeling for 12 months with serum levels of NT-proBNP (N-Terminal proBrain Natriuretic Peptide), identified in the acute phase of myocardial infarction. In 108 patients with acute ST- elevated myocardial infarction, the biomarker is an amino-terminal fragment of the precursor of brain natriuretic peptide precursor. In patients with postinfarction left ventricular remodeling, the values of the NT-proBNP are higher (p = 0.03), which correlate with the degrees of systolic and diastolic dysfunction of the left ventricle (p <0.05). The evaluation of this biomarker in the acute phase of myocardial infarction may be of clinical importance for the selection of patients at high risk of developing heart failure.

The purpose of the study is to assess the features of clinical manifestations of generalized tuberculosis in HIV- positive patients living in the conditions of the Northern Region. Indicators of a microbiology testing of sputum, epithelial lining fluids, exudate, cerebrospinal fluids separated from fistula, biopsy and operational material, results of a computed tomography of lungs of 30 patients with generalized tuberculosis and HIV infection undergoing treatment in the Surgut Clinical Antituberculosis Dispensary are studied. Tuberculosis is detected in the following extrapulmonary localizations: urogenital system in 12 patients (40 %); meningitis in 9 (30 %); spondylitis in 9 (30 %); intestines in 8 (26.7 %); pleural effusion in 5 (16.7 %). Damage of three and more systems is detected in 6 patients (20 %). Among the 14 patients with generalized tuberculosis and HIV infection egesting mycobacteria of tuberculosis, in 5 of them, an abacillation (35.7 %) is reached. The 23.3% (n = 7) of patients have fatal cases.

The aim of the study is to evaluate the results of plastic surgeries to patients with breast cancer using the digital modeling method in comparison with standard approaches. Female patients with breast cancer are divided into 2 groups: in the 1st group (15 people) the preoperative planning is carried out according to the standard procedure; in the 2nd group (15 people), the planning is carried out using the 3D-visualization program Crisalix for preoperative 3D-modeling of the mammary gland. All patients underwent single-step breast reconstruction with silicone implants for cancer. The use of digital modeling in plastic surgeries in patients with breast cancer has reduced the incidence of complications by 33 % in the early stages and by 20 % in the late postoperative periods.

The goal of the study is to compare clinical, morphological and instrumental indicators of ulcerative colitis and Crohn’s disease in patients with a mild course of the disease. Two groups of patients are examined: 28 patients with ulcerative colitis (group 1) and 10 patients with Crohn’s disease (group 2). In patients with ulcerative colitis, the most common instrumental and morphological indicators are proctitis (64 %) and continuous inflammation (64 %), comprometation of crypts (crypt abscess or deformation of crypts (38 % and 18 %)). A “cobblestone”-like appearance of tissues (70 %), intermittent damage to the mucous membrane (60 %) and abdominal pain (50 %) are frequently discovered in patients with Crohn’s disease. Erosive and ulcerous defects and lymphoplasmacytic infiltration of the intestinal mucosa must be verified in detail in the protocol of colonoscopy and morphological examination.

The purpose of the study is to estimate the frequency and intensity of a gastric mucosa lipomatosis in patients with gastric cancer. The research includes operational material of 110 patients with gastric cancer treated in Oncology Department of the Surgut Regional Clinical Hospital. According to results of clinical evidence, two groups are formed: 63 and 47 patients with gastric cancer having and not having visceral symptoms of a systemic undifferentiated connective tissue dysplasia. The morphological examination of a gastric mucosa is conducted after preparation of paraffin sections by a standard technique with hematoxylin-eosin staining (the light microscope Nikon Eclipse Ni M570E, Japan). The intensity of lipomatosis is estimated according to the rating scale developed by the authors. High frequency of a gastric mucosa lipomatosis accompanying gastric cancer is detected. The value of such lipomatosis is not thoroughly clear but the known effects of fatty tissue (endocrine, development of immune inflammation) do not exclude the impact of local deposits of fatty tissue on carcinogenesis. This demands an extension study.

The aim of the study is to evaluate the clinical efficacy of platelet concentrates transfusion for patients with a hematological, oncological and surgical profile in the District Clinical Hospital of Khanty-Mansiysk. The evaluation of the clinical efficacy of platelet concentrates transfusion obtained by the method of apheresis in patients (n =50) is carried out. It is shown that thrombocytapheresis does not significantly affect the hematological parameters of the blood of the donor. It is found that a reliable method for determining the efficiency of transfusion is to determine the corrected platelet growth 24 hours after the end of the platelet transfusion. It is revealed that the loss of platelet count in the blood of donors after cytapheresis is 33 %. In patients with an onco-hematological, cardiac or surgical profile, platelet transfusion consists of 460 × 109 cells in 314 ml. The corrected platelet count 24 hours after the procedure is 17.8 × 109/l with a microscopical evaluation method and 14.4 × 109/l when measured on a hematology analyzer.

In the most developed countries, the selective catheter-directed thrombolysis is widely used in primary subclavian thrombosis or Paget - Schroetter disease. The method has proved to be effective and safe in this pathology. The article presents a case of successful selective catheter-directed thrombolysis with Alteplase in a55-year-old male with Paget - Schroetter disease.

The purpose of the study is to identify the age-related characteristics of the aging rate, levels of anxiety and components of the quality of life in older women living in the Arctic zone of Russia. The 743 women aged 60-69 years, who are residents of the Arkhangelsk Oblast are examined. The rates of aging are determined using the biological and proper biological age formula according to V. P. Voitenko. Diagnosis of self-esteem is studied according to levels of state and trait anxiety by Ch. D. Spielberger and Yu. L. Khanin. Physical and psychological components of the quality of life are studied according to the questionnaire SF-36v2. Statistical processing of the obtained data is performed using the computer programs “SPSS 22” and “Epi Info 3.4.3”. It has been established that women over 64 years have an increase in state anxiety, a decrease in the physical and psychological components of the quality of life associated with health.

The goal of the article is to assess the quality of life of patients with epilepsy and clinical manifestations of craniocerebral disproportion with a low CSF-cranial index related to modified treatment. The medical records of36 and 42 patients with epileptic seizures, normal and small volume of reserve cerebrospinal fluid spaces and the level of the CSF-cranial index using standard therapy are analyzed. The main group consists of 46 patients with a small volume of reserve cerebrospinal fluid spaces and a CSF-cranial index using a modified treatment. The quality of life and the severity of depression are assessed using the QOLIE-31 and Beck Depression Inventory questionnaires conducted for 2 or more years. It has been revealed that the modified treatment of epilepsy is a method of prevention in maintaining a subjective assessment of the quality of life level and helps to reduce the degree of anxiety and depressive disorders.

The purpose of the study is to determine the correlation and conjugation of the adaptation processes and reproduction of the young population of the subarctic region and the prospects for the clinical model of adaptation medicine. We examined: 280 pregnant women and their newborns during the physiological course of gestation (I group); 297 female patients with excess and deficit weight (II-1 and II-2 subgroups) and 107 women of the control group (II-3 subgroup). An analysis of medical files of 8 puerperas, who died in obstetric hospitals of the region for the past 5 years, is also considered. In prospective and retrospective studies are analyzed: clinical parameters and heart rate variability, adaptive potential using the R. M. Bayevskiy formula, neurovegetative status using the method of S. A. Kleshchenogov and A. N. Fleishman, types of adaptive reactions using the method L. H. Garkavi et al. Conjugation, significant stress and borderline states of adaptation mechanisms, metabolic disorders in women of the subarctic region, the pregnant with altered body weight are reported. The pathogenetic mechanisms of these processes are equivalent to the clinical model of “adaptation diseases”.

The goal of the study is to develop prevention methods based on the results of the tuberculosis epidemiological process in medical workers performing autopsy examinations of dead bodies with active tuberculosis. Today tuberculosis is characterized by multidrug resistance, which makes treating patients harder and creates more possibilities of infecting others. The situation on the incidence of tuberculosis in medical workers performing autopsies in the city of Surgut for the period from 2011 to 2018 is studied. A high incidence rate of tuberculosis among medical workers - pathologists and forensic pathologists - is shown. This requires appropriate antiepidemic measures among specialists.

The purpose of the study is to analyze the results of a sociological survey with an assessment of the awareness and competence of patients in the field of infectious safety in Cardiologic and Cardiac Surgery departments of the hospital. The questioning is conducted in the Surgut District Cardiologic Dispensary “Center of Diagnostics and Cardiovascular Surgery”. Two questionnaires are developed. The total of patients participated in the study is 237: the 101 patients responded to the questionnaire 1, the 136 patients responded to the questionnaire 2. All of the patients are satisfied with the conditions of stay in the hospital on the whole and highly appreciated infectious safety measures.

The purpose of the study is to present modern concepts of formation and transport of the lymph, the value of the lymphatic system under normal and pathological conditions, the mechanisms of nervous, humoral and endothelium-dependent regulation of the contractive activity of lymphatic vessels. The lymphatic system plays a key role in ensuring the absorption of macromolecules and fluid from the interstitial space and returning them to the systemic blood flow, takes a direct part in the immune function. The lymphatic system is involved in all pathological processes. The transport function of the lymphatic system is the most important component of maintaining tissue homeostasis.

The aim of the study is to determine the pathogenesis and clinical manifestations of intra-abdominal hypertension in patients with acute intestinal obstruction for optimization of surgical treatment approaches. The treatment results of 72 patients with acute intestinal obstruction (43 and 29 patients with adhesive and obturational intestinal obstruction) are evaluated. In order to assess organ and systemic disturbances, intra-abdominal pressure is measured by an indirect method according to the procedure of Kron et al. [1] with the placement of an “open” catheter in the bladder. Experimental studies are also conducted. The II st. intra-abdominal hypertension is modeled and tissues of the small intestine and kidneys are morphologically examined in 10 rabbits of the Chinchilla breed. In patients with elevated abdominal pressure above the norm, a fluid imbalance, hypoproteinemia, reduction in oncotic pressure and inflammation develop. The anatomical substrate of the small intestine and the kidneys revealed damage to the enterocytes, impaired microcirculation, signs of inflammation.