ANALYSIS OF MEAN PLATELET VOLUME IN NONNEOPLASTIC PATHOLOGY AND CERVICAL CANCER ASSOCIATED WITH SYSTEMIC DYSPLASIA OF CONNECTIVE TISSUE
https://doi.org/10.34822/2304-9448-2021-4-88-93
Abstract
The study aims to analyze the platelet volume and screening coagulogram in nonneoplastic pathology and cervical cancer, associated and non-associated with systemic non-differential dysplasia of connective tissue. Material and methods. The comparative statistical analysis (with Mann-Whitney test and Сhi-squared test with p < 0.05) of platelet volume, their quantity and screening coagulogram in 204 women with nonneoplastic pathology of cervix and cervical cancer with (1st and 3rd groups, accordingly) and without (2nd and 4th groups) dysplasia of connective tissue has been carried out. Results. Disturbances in the blood system prevailed in both groups with dysplasia of connective tissue: thrombocytosis and increase in prothrombin ratio that characterize tendency for hypercoagulability were statistically significantly higher in the 1st group than in the 3rd group and twice as frequent in the 1st group than in the 2nd group. Anemia and hyperfibrinogenemia prevailed in both groups with cervical cancer, with or without dysplasia of connective tissue. Statistically significant increase in platelet volume in groups with dysplasia of connective tissue is recorded not only in comparison with corresponding groups without dysplasia but also in groups with cervical cancer. Detected tendencies for hypercoagulability and increase in platelet volume (both in dysplasia of connective tissue and in cervical cancer) can possess significance for assessment of connection with features of pathological process flow and its treatment, which requires the further research.
About the Author
L. A. Naumova
Surgut State University, Surgut
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor, Department of Pathophysiology and General Pathology, Medical Institute
Е-mail: naumovala@yandex.ru
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For citations:
Naumova L.A. ANALYSIS OF MEAN PLATELET VOLUME IN NONNEOPLASTIC PATHOLOGY AND CERVICAL CANCER ASSOCIATED WITH SYSTEMIC DYSPLASIA OF CONNECTIVE TISSUE. Vestnik SurGU. Meditsina. 2021;(4 (50)):88-93. (In Russ.) https://doi.org/10.34822/2304-9448-2021-4-88-93
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