ROLE OF INFECTIOUS AGENT IN DEVELOPMENT OF SYSTEMIC INFLAMMATORY PROCESS DURING POSTPARTUM ENDOMETRITIS
Abstract
The aim of the study is to estimate the role of the pathogenic microbiota in the development of the systemic inflammatory response. Material and methods. The study included 30 women with physiological puerperium (control group) and 80 women with postpartum endometritis (main group). We determined the cytokines levels of blood: interleukin-1-beta (IL-1β), tumor necrosis factor alpha (TNFα), interleukin 10 (IL-10), acute phase proteins on the 1st and 5th day of postpartum endometritis. The correlation with the results of detected microbiota of the uterus with postpartum endometritis was studied. Results. A direct dependence was revealed between the microorganism resistance and the α-1 globulin and IL-1β in the blood by the 5th day. It is proved that the determination of the level of IL-1β in the blood by the 5th day from the onset of the disease has the most predictive value for determining the further tactics of the treatment.
About the Authors
V. T. Dolgikh
V. A. Negovsky Research Institute of General Reanimatology, Moscow
Russian Federation
Doctor of Science (Medicine), Professor, Leading Researcher, Laboratory of Clinical Pathophysiology of Critical States, Scientific Secretary, Scientific Secretary of the Doctoral Council, Honoured
Science Worker of the Russian Federation
Russian Federation
Doctor of Science (Medicine), Professor, Leading Researcher, Laboratory of Clinical Pathophysiology of Critical States, Scientific Secretary, Scientific Secretary of the Doctoral Council, Honoured
Science Worker of the Russian Federation
S. V. Barinov
Omsk State Medical University
Russian Federation
Doctor of Science (Medicine), Professor, Head, Department of Obstetrics and Gynecology Number 2
Russian Federation
Doctor of Science (Medicine), Professor, Head, Department of Obstetrics and Gynecology Number 2
E. S. Blauman
Omsk State Medical University
Russian Federation
Postgraduate, Department of Obstetrics and Gynecology Number 2
Russian Federation
Postgraduate, Department of Obstetrics and Gynecology Number 2
L. D. Popova
Regional Clinical Hospital, Omsk
Russian Federation
Head, Clinical Microbiology Laboratory, (Bacteriology), Bacteriologist
Russian Federation
Head, Clinical Microbiology Laboratory, (Bacteriology), Bacteriologist
D. G. Novikov
Omsk State Medical University
Russian Federation
PhD (Medicine), Head, Central Research Laboratory (CRL)
Russian Federation
PhD (Medicine), Head, Central Research Laboratory (CRL)
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Review
For citations:
Dolgikh V.T., Barinov S.V., Blauman E.S., Popova L.D., Novikov D.G. ROLE OF INFECTIOUS AGENT IN DEVELOPMENT OF SYSTEMIC INFLAMMATORY PROCESS DURING POSTPARTUM ENDOMETRITIS. Vestnik SurGU. Meditsina. 2019;(3 (41)):76-80. (In Russ.)
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