MECHANISMS OF MICROCIRCULATORY DISORDER IN INTESTINE DURING VARIOUS STAGES OF INTRA-ABDOMINAL HYPERTENSION WITH ACUTE SURGICAL PATHOLOGY
Abstract
The aim of the study is to determine the pathogenesis of microcirculatory disorder in the intestine during various stages of intra-abdominal hypertension secondary to peritonitis. Material and methods. Collection and analysis of literature are made in Russian and international electronic systems such as the Digital Dissertation Library of the Russian State Library, eLIBRARY.RU, Springer, Web of Science, MEDLINE. The analysis is performed
within the 2014-2019. The used keywords are intra-abdominal hypertension, peritonitis, adhesion molecule, enteral insufficiency, microcirculatory disorder. Results. Biologically active substances, proinflammatory mediators and cytokines are main factors in microcirculatory disorder development. Features of microcirculatory disorders during various stages of intra-abdominal hypertension are compared with the clinical picture, pathomorphological changes, and progression of enteral insufficiency. The role of PECAM-Flk-1 endothelial mechanosensory complex as the early marker of endothelial dysfunction by nitric oxide activation is identified.
within the 2014-2019. The used keywords are intra-abdominal hypertension, peritonitis, adhesion molecule, enteral insufficiency, microcirculatory disorder. Results. Biologically active substances, proinflammatory mediators and cytokines are main factors in microcirculatory disorder development. Features of microcirculatory disorders during various stages of intra-abdominal hypertension are compared with the clinical picture, pathomorphological changes, and progression of enteral insufficiency. The role of PECAM-Flk-1 endothelial mechanosensory complex as the early marker of endothelial dysfunction by nitric oxide activation is identified.
About the Authors
E. V. Bubovich
Surgut State University
Russian Federation
PhD (Medicine), Associate Professor, Department of Pathophysiology and General Pathology, Medical Institute
Russian Federation
PhD (Medicine), Associate Professor, Department of Pathophysiology and General Pathology, Medical Institute
O. N. Startseva
Surgut State University
Russian Federation
Lecturer, Postgraduate, Department of Pathophysiology and General Pathology, Medical Institute
Russian Federation
Lecturer, Postgraduate, Department of Pathophysiology and General Pathology, Medical Institute
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Review
For citations:
Bubovich E.V., Startseva O.N. MECHANISMS OF MICROCIRCULATORY DISORDER IN INTESTINE DURING VARIOUS STAGES OF INTRA-ABDOMINAL HYPERTENSION WITH ACUTE SURGICAL PATHOLOGY. Vestnik SurGU. Meditsina. 2019;(2 (40)):69-74. (In Russ.)
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