The paper analyzes the main stages of type III reactions formation and development. The characteristics of certain diseases, having this type of reaction have been considered.

The study objective is an evidence-based approach to assessing efficiency of targeted breast cancer therapy with Pertuzumab, Trastuzumab and Docetaxel. The major studies showing efficiency and safety of such treatment have been analyzed.

The study objective is determining the possibility and expedience of multislice computer tomography (MSCT) for choosing the most suitable surgery approach in early post-operative period in patients with suspected peritonitis and HIV end-stage. 32 patients with terminal HIV, abdominal TB and peritonitis have been divided into 3 groups based on their MSCT scan results: group I: the patients with uncontained inflammation and substantial inflammatory lymph in the abdomen and thoracic cavity, with long-term, severe, relapsing course; group II: relapsing bowel perforation exposing into contained internal cavities, with intestinal fistulas; group III: patients with “dry” contained peritonitis, and clusters of swollen mesenteric lymph nodes. The study has shown that MSCT has to be used to select a surgical approach.

The study objective is finding new methods for bronchial asthma diagnostics and asthma development risk assessment in infants and preschoolers in order to prevent the decease development into severe asthma. As a result of the retrospective analysis and follow-up of 103 children with diagnosed bronchial asthma, new diagnostic predictors for early diagnosis of the disease have been revealed. They are: increased body mass index in 1 and 2 years of life (above 90 and 97 percentile); excessive high frequency breathing noise measured with computer bronchophonography, positive bronchodilation tests; higher nitric oxide content in the exhaled air.

The objective is studying the contribution of cholestasis and transaminase enzymatic profile to bacteriocholia development in patients with biliary tract disease. The patients with transient bacteriocholia < 10³ KOE/ml have revealed a positive correlation between bacteriocholia level and laboratory markers of cholestasis. In the patients with biliary tract diseases and bacteriocholia > 10³ KOE/ml an excess of absolute cholestasis marker levels, cytolysis, and higher occurrence rate have been found as compared to a group of patients without bacteriocholia.

The study objective is hospital mortality rate assessment in patients with acute cerebrovascular accidents treated at the Stroke Neurosurgery Dept., Surgut Clinical Emergency Hospital, between 2012 and 2014. The pejorative indicators in patients with acute cerebrovascular accidents are age over 60, being male, hemorrhagic stroke, impairment of consciousness, and need for surgery.

The study objective is assessment of EEG, central hemodynamics indicators, and intensive care options for acute amlodipine poisoning. The EEG and central hemodynamics indicator variations have been clarified; acute amlodipine poisoning therapy has been proposed. Intensive care stabilizes the patient and exclude toxic-related complications of acute poisoning.

The study considers post-thrombotic decease after deep venous thrombosis in upper limbs for a specific clinical case. A balloon angioplasty application to comprehensive surgical treatment with post-thrombotic decease of upper limbs is presented. The procedure has produced good angiographic results: the subclavian vein has expanded up to 10 mm; the positive affect is a long-term one.

The study objective is estimating chronic kidney disease development forecasts in chronic obstructive pulmonary disease (COPD) patients living in the Northern regions. The study has included 145 COPD patients. The chronic kidney disease predictors in COPD patients are senior age, smoking, overweight and obesity, severe bronchial obstruction, pulmonary hypertension, left ventricular hypertrophy. A negative correlation between glomerular filtration rate (CKD-EPI), albumin level (r = -0.268, p < 0.05) and alpha-1 globulin (r = -0.334, p < 0.05) points to their effect on glomerular filtration decrease. These indicators can be used as chronic kidney disease markers.

The objective is pathogenic rationale behind using nutrients to suppress functional and metabolic disorders in children exposed to standard chemotherapy after surgical medulloblastoma removal. The study covers 80 children 6 to 16 years old with cerebellum medulloblastoma who have undergone surgical tumor removal with subsequent chemotherapy. Another 40 patients have undergone surgical tumor removal with subsequent chemo- and radiation therapy, and 40 children who have received chemo, radiation therapy, and extra nutrients being Nutricomp Standard Liquid isocaloric mixture. It has been found that the nutrients reduce secondary alteration, facilitate faster tissue reparation, normalize free radical oxidization, reduce catabolic rate and intoxication, stimulate hematopoiesis.

The study objective is enhancing parasite extermination with impulse electric discharge for comprehensive abdominal abscess treatment in patients with echinococcosis. The paper presents an experimental study of pulsed electric discharge effects on hydatid cyst embryos. The changes in Echinococcus cell morphology exposed to pulsed discharge treatment has been identified. It has been shown that a 120 sec electric charge exposure with a URAT-1m device completely destroys echinococcus cyst embryos.

The study objective is a comparative analysis of EEG channels in no-pathology and various epilepsy disorder patients. It has been found that the EEG signal correlation in epileptic patients are extreme compared to that in healthy patients.

The study objective is developing a tutorial algorithm for teaching primary epidemic response actions in infection-exposed areas. The algorithm has been used in the Epidemiology course and has facilitated the on-hands training.

The study objective is defining the characteristics of the patient pool treated at the Chronic TB Dept., Surgut Clinical TB Health Center. It has been found that most patients are males around 40 years old, who have been convicted and served time in prison, with disseminated and fibroid cavernous TB, multiple and extensive drug resistance. Over a half are not Surgut residents; over a third are HIV positive.

The objective is studying the feasibility of a Bayes-based personal breast cancer risk assessment procedure and software intended for primary screening. The breast cancer development factors have been estimated in terms of diagnostic value with a Bayes-based algorithm and a likelyhood ratio. The proposed test’s sensitivity and selectivity have been measured. The test has been implemented as an application. The application is valid and suitable for deployment.