COMPARISON OF LITHIUM CHLORIDE EFFECT IN DOSE OF 63 MG/KG AND 21 MG/KG AFTER 60 AND 180 MINUTES IN TRAUMATIC BRAIN INJURY MODELING
https://doi.org/10.35266/2949-3447-2025-3-12
Abstract
Traumatic brain injury is a primary cause of death and disability, with significant physical, social and economic effects. The study of neuroprotective properties of pharmacological drugs is an important scientific task. Comparison of the lithium chloride effect in the doses of 63 mg/kg and 21 mg/kg after 60 and 180 minutes in open traumatic brain injury experimental modeling in rats is the research aim. Male Wistar rats (n = 60) are included in the study: control group, sham-operated animals and four groups depending on the administered dose of lithium chloride and time intervals. On day 14 after traumatic brain injury, magnetic resonance imaging is utilized to examine the extent of brain damage in rats. Comparative analysis of lithium chloride’s effect on brain damage severity across the studied groups indicates that a 63 mg/kg dose, administered 60 minutes post-injury, demonstrates optimal efficacy in the traumatic brain injury model.
About the Authors
D. T. Sharikadze
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow
Russian Federation
Russian Federation
Candidate
M. V. Gabitov
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Researcher
O. A. Grebenchikov
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Chief Researcher
V. T. Dolgikh
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor, Chief Researcher
A. N. Kuzovlev
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Docent, Deputy Director, Head
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Review
For citations:
Sharikadze D.T., Gabitov M.V., Grebenchikov O.A., Dolgikh V.T., Kuzovlev A.N. COMPARISON OF LITHIUM CHLORIDE EFFECT IN DOSE OF 63 MG/KG AND 21 MG/KG AFTER 60 AND 180 MINUTES IN TRAUMATIC BRAIN INJURY MODELING. Vestnik SurGU. Meditsina. 2025;18(3):92-99. (In Russ.) https://doi.org/10.35266/2949-3447-2025-3-12
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