SHORT-TERM MARKERS OF GLYCEMIC CONTROL IN GESTATIONAL DIABETES MELLITUS
https://doi.org/10.35266/2949-3447-2025-2-6
Abstract
We studied the diagnostic and prognostic significance of fructosamine and 1,5-anhydroglucitol levels in peripheral blood during pregnancy complicated by gestational diabetes mellitus. Analysis demonstrated the absence of significant differences in marker levels relative to glycated hemoglobin and fasting plasma glucose levels in the presence of mild iron deficiency anemia. Higher fructosamine levels in the third trimester were associated with fetal macrosomia.
About the Authors
L. D. Belotserkovtseva
Surgut State University;
Surgut District Clinical Center of Maternity and Childhood Health Care, Surgut
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor, Honored Doctor of Russian Federation, Head of the Department of Obstetrics, Gynaecology and Perinatology, President
E. N. Erchenko
Surgut State University;
Surgut District Clinical Center of Maternity and Childhood Health Care, Surgut
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Docent
I. I. Mordovina
Surgut State University;
Surgut District Clinical Center of Maternity and Childhood Health Care, Surgut
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Docent
T. V. Vasilyeva
Surgut State University;
Surgut District Clinical Center of Maternity and Childhood Health Care, Surgut
Russian Federation
Russian Federation
Head of Clinical Diagnostic Laboratory
References
1. Гестационный сахарный диабет : клинические рекомендации. 2024. URL: https://cr.minzdrav.gov.ru/view-cr/841_1 (дата обращения: 01.01.2025).
2. Алгоритмы специализированной медицинской помощи больным сахарным диабетом : клинические рекомендации. 11-й выпуск / под ред. И. И. Дедов, М. В. Шестакова, А. Ю. Майоров. М. : Российская ассоциация эндокринологов, 2023. 157 с.
3. Белоцерковцева Л. Д., Конченкова Е. Н., Киличева И. И. и др. Ведение беременности при гестационном сахарном диабете // Вопросы гинекологии, акушерства и перинатологии. 2020. Т. 19, № 3. С. 40–44.
4. Billionnet C., Mitanchez D., Weill A. et al. Gestational diabetes and adverse perinatal outcomes from 716,152 births in France in 2012 // Diabetologia. 2017. Vol. 60. P. 636–644. https://doi.org/10.1007/s00125-017-4206-6.
5. Ladfors L., Shaat N., Wiberg N. et al. Fetal overgrowth in women with type 1 and type 2 diabetes mellitus // PLoS One. 2017. Vol. 12, no. 11. P. e0187917. https://doi.org/10.1371/journal. pone.0187917.
6. Santos M. J., Fernandes V., Marques O. et al. Effect of maternal body mass index and weight gain in women with gestational diabetes on the incidence of large-for-gestationalage infants // Diabetes & Metabolism. 2016. Vol. 42, no. 6. Р. 471–474. https://doi.org/10.1016/j.diabet.2016.06.008.
7. Mendes N., Ribeiro R. T., Serrano F. Beyond self-monitored plasma glucose and HbA1c: the role of non-traditional glycaemic markers in gestational diabetes mellitus // Journal of Obstetrics and Gynaecology. 2018. Vol. 38, no. 6. P. 762–769. https://doi.org/10.1080/01443615.2017.1412409.
8. Ribeiro R. T., Macedo M. P., Raposo J. F. HbA1c, fructosamine, and glycated albumin in the detection of dysglycaemic conditions // Current Diabetes Reviews. 2016. Vol. 12, no. 1. P. 14–19. https://doi.org/10.2174/1573399811666150701143112.
9. Delgado M. R., Novik A. V., Cardemil M. F. et al. Plasma fructosamine to evaluate metabolic control among women with gestational diabetes // Revista Médica de Chile. 2011. Vol. 139, no. 11. Р. 1444–1450.
10. Mendes N., Alves M., Andrade R. et al. Association between glycated haemoglobin, glycated albumin and fructosamine with neonatal birthweight and large-for-date status infants in gestational diabetes mellitus: A prospective cohort study // Journal of Obstetrics and Gynaecology. 2019. Vol. 39, no. 6. P. 768–773. https://doi.org/10.1080/01443615.2019.1584886.
11. Poupon P., Foussard N., Helmer C. et al. Serum fructosamine predicts macrosomia in well-controlled hyperglycaemic pregnant women: An observational cross-sectional study // Diabetes & Metabolism. 2020. Vol. 46, no. 3. P. 219–222. https://doi.org/10.1016/j.diabet.2019.07.003.
12. Климонтов В. В., Дашкин М. В. 1,5-ангидроглюцитол при сахарном диабете: роль в диагностике, скрининге, оценке гликемического статуса и прогнозе осложнений // Сахарный диабет. 2020. Т. 23, № 3. С. 250–259. https://doi.org/10.14341/DM10258.
13. Арбузова М. И., Ильин А. В. Перспективен ли тест 1,5-ангидро-D-глюцитол для контроля компенсации и лечения сахарного диабета? // Сахарный диабет. 2010. Т. 13, № 1. С. 123–125. https:// doi.org/10.14341/2072-0351-6027.
14. Nowak N., Skupien J., Cyganek K. et al. 1,5-Anhydroglucitol as a marker of maternal glycaemic control and predictor of neonatal birthweight in pregnancies complicated by type 1 diabetes mellitus // Diabetologia. 2013. Vol. 56, no. 4. P. 709–713. https://doi.org/10.1007/s00125-013-2830-3.
15. Delaney S. S., Coley L. Y., Brown Z. 1,5-Angydroglucitol: A new predictor of birth weight in diabetic pregnancies // European Journal of Obstetrics & Gynecology and Reprouctive Biology. 2015. Vol. 189. P. 55–58. https://doi.org/10.1016/j.ejogrb.2015.03.021.
16. Нормальная беременность : клинические рекомендации. 2023. URL: https://5-point.ru/wp-content/uploads/Normal_beremennosty_2023.pdf (дата обращения: 01.01.2025).
17. Welter M., Boritza K. C., Anghebem-Oliveira M. I. et al. Reference intervals for serum 1,5-anhydroglucitol in children, adolescents, adults and pregnant women // Clinica Chimica Acta. 2018. Vol. 486. P. 54–58. https://doi.org/10.1016/j.cca.2018.07.018.
Review
For citations:
Belotserkovtseva L.D., Erchenko E.N., Mordovina I.I., Vasilyeva T.V. SHORT-TERM MARKERS OF GLYCEMIC CONTROL IN GESTATIONAL DIABETES MELLITUS. Vestnik SurGU. Meditsina. 2025;18(2):45-51. (In Russ.) https://doi.org/10.35266/2949-3447-2025-2-6
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