Preview

Vestnik SurGU. Meditsina

Advanced search

INDICATORS OF BLOOD PRESSURE IN MEN WITH ARTERIAL HYPERTENSION DEPENDING ON PSORIASIS

https://doi.org/10.35266/2949-3447-2024-1-6

Abstract

The study aims to examine blood pressure indicators in men with arterial hypertension, their dependance on psoriasis, and identification of endothelium dysfunction, with vascular endothelial growth factor in combination of these diseases. The study included 168 male patients who were on outpatient treatment for stage 2 hypertension, of which 86 patients had a progressive stage of moderate severity. All patients underwent daily blood pressure monitoring and a blood test for the content of vascular endothelial growth factor. It was revealed that the level of vascular endothelial growth factor was statistically significantly higher (160.3 ± 49.9 pg/ml, p = 0.0002) in patients with a combination of hypertension and psoriasis than in those with hypertension without psoriasis. In patients with hypertension and psoriasis, statistically significantly (p < 0.05) higher variability of systolic arterial hypertension in the daytime and at night, as well as the rate of morning rise in systolic and diastolic blood pressure were noted. Also, in patients with hypertension and psoriasis, the normal daily blood pressure rhythm (dipper) was recorded more rarely (χ2 = 3.97, p = 0.046) – in 30.2 % of cases, while in patients with hypertension, the dipper daily rhythm was registered in 45 % of cases. The presence of psoriasis aggravates the course of arterial hypertension, a patient with hypertension and psoriasis requires more attention from a general physician, cardiologist and dermatovenerologist.

About the Authors

Yuliya N. Kurganova
Central Clinical Medical Unit named after Honored Medical Officer of Russia V. A. Egorov, Ulyanovsk
Russian Federation

Cardiologist



Vladimir A. Razin
Ulyanovsk State University, Ulyanovsk
Russian Federation

Doctor of Sciences (Medicine), Docent



Aleksey S. Nesterov
Ulyanovsk State University, Ulyanovsk
Russian Federation

Doctor of Sciences (Medicine), Professor



Yuliya Yu. Sidorova
Ulyanovsk District Clinical Medical Center for Patients with Radiation Exposure and Professional Pathology named after Hero of the Russian Federation V. M. Maksimchuk, Ulyanovsk
Russian Federation

General Physician



References

1. Артериальная гипертензия у взрослых : клинич. рекомендации. 2020. URL: https://webmed.irkutsk.ru/doc/pdf/hprcs.pdf (дата обращения: 15.01.2024).

2. Бойцов С. А., Драпкина О. М., Шляхто Е. В. и др. Исследование ЭССЕ-РФ (Эпидемиология сердечно-сосудистых заболеваний и их факторов риска в регионах Российской Федерации). Десять лет спустя // Кардиоваскулярная терапия и профилактика. 2021. Т. 20, № 5. С. 3007.

3. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice // Russian Journal of Cardiology. 2022. Vol. 27, no. 7. P. 5155.

4. Асхаков М. С., Чеботарев В. В. Псориаз: современное представление о дерматозе // Медицинский вестник Северного Кавказа. 2017. Т. 12, № 2. С. 225–229.

5. Кожанов А. С. Эпидемиологические и клинические особенности псориаза на современном этапе // Медицина Кыргызстана. 2015. № 1. С. 34–37.

6. Sobhan M., Farshchian M. Associations between body mass index and severity of psoriasis // Clin Cosmet Investig Dermatol. 2017. Vol. 10, P. 493–498.

7. Hu S. C., Lan C. E. Psoriasis and cardiovascular comorbidities: Focusing on severe vascular events, cardiovascular risk factors and implications for treatment // Int J Mol Sci. 2017. Vol. 18, no. 10. P. 2211.

8. Ogdie A., Yu Y., Haynes K. et al. Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: A population-based cohort study // Ann Rheum Dis. 2015. Vol. 74, no. 2. P. 326–332.

9. Schlich R., Willems M., Greulich S. et al. VEGF in the crosstalk between human adipocytes and smooth muscle cells: Depotspecific release from visceral and perivascular adipose tissue // Mediators Inflamm. 2013. Vol. 2013. P. 982458.

10. Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis // Kidney Int. 1999. Vol. 56, no. 3. P. 794–814.

11. Maddeddu P. Therapeutic angiogenesis and vasculogenesis for tissue regeneration // Exp Physiol. 2005. Vol. 90, no. 3. P. 315–326.

12. Артериальная гипертензия у взрослых : клинич. рекомендации. 2020. URL: https://cr.minzdrav.gov.ru/recomend/62 (дата обращения: 15.01.2024).

13. Псориаз : клинич. рекомендации. 2023. URL: https://cr.minzdrav.gov.ru/recomend/234_2 (дата обращения: 15.01.2024).

14. Chenniappan M. Blood pressure variability: Assessment, prognostic significance and management // J Assoc Physicians India. 2015. Vol. 63, no. 5. P. 47–53.

15. Горбунов В. М. Современные представления о вариабельности артериального давления // Рациональная фармакотерапия в кардиологии. 2012. Т. 8, № 6. С. 810–818.


Review

For citations:


Kurganova Yu.N., Razin V.A., Nesterov A.S., Sidorova Yu.Yu. INDICATORS OF BLOOD PRESSURE IN MEN WITH ARTERIAL HYPERTENSION DEPENDING ON PSORIASIS. Vestnik SurGU. Meditsina. 2024;17(1):49-52. (In Russ.) https://doi.org/10.35266/2949-3447-2024-1-6

Views: 81


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2949-3447 (Online)