A MODERN LOOK AT TRADITIONAL MARKERS IN SEPSIS
https://doi.org/10.35266/2949-3447-2023-4-9
Abstract
The study aims to examine modern views of common sepsis markers, new data on their pathophysiological role and significance in determining the severity, efficacy of care, and prognosis of sepsis. The literature was searched for in such information sources as CyberLeninka, PubMed, Nature Pathology, MEDLINE, and PLOS ONE. The search depth was primarily 7–10 years and included only fundamental publications. The keywords used in the study are markers of inflammation and cellular damage, lactate dehydrogenase, C-reactive protein, and sepsis. A comprehensive understanding of the pathophysiological significance of widely available in clinical practice biomarkers of many diseases, including sepsis, such as lactate dehydrogenase and C-reactive protein, is made possible by the results of numerous recently published research on these markers. The data obtained may provide diagnostic, therapeutic, and prognostic significance. At the same time, there is no unambiguous opinion on and understanding of certain markers both in the early diagnosis of sepsis and in the assessment of the severity of its course and prognosis. The absence of differentiated research approaches used for various isoforms of C-reactive protein and the accessibility of modern highly sensitive methods for determining the markers’ level to widespread use are the partial reasons for that, which results in controversial findings about their significance. Additionally, lactate dehydrogenase and C-reactive protein can portray important processes in a patient’s organism, including those unavailable for assessment via other methods. Therefore, they can help in decision-making in the clinical process, particularly in selecting an adequate and timely antibacterial therapy. The literature data also suggests that more research into the pathophysiologic role of these biomarkers in sepsis and other human diseases using highly sensitive methods is required.
About the Authors
Lyudmila A. Naumova
Surgut State University, Surgut
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor
Mudrinat B. Yallyev
Surgut State University, Surgut
Russian Federation
Russian Federation
Postgraduate, Anesthesiologist-Resuscitator
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Review
For citations:
Naumova L.A., Yallyev M.B. A MODERN LOOK AT TRADITIONAL MARKERS IN SEPSIS. Vestnik SurGU. Meditsina. 2023;16(4):61-69. (In Russ.) https://doi.org/10.35266/2949-3447-2023-4-9
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