ASSOCIATION OF POLYMORPHIC VARIANTS OF THE ANGIOTENSIN-CONVERTING ENZYME GENE (RS4646994) WITH A DECREASE IN PHYSICAL PERFORMANCE IN SERVICEMEN OF THE AEROSPACE FORCES OF THE RUSSIAN FEDERATION

The study aims to evaluate the association of polymorphic variants of the angiotensin-converting enzyme gene (rs4646994) with a decrease in physical performance in servicemen of the Aerospace Forces of the Russian Federation with hypoxia. Materials and methods. 295 male military personnel serving in various climatic and geographic zones were examined. Polymorphisms of the gene were determined by polymerase chain reaction. The DT-Prime amplifier enabled real-time genotyping of gene samples. The significance of the differences in the mean values of quantitative indicators with normal distributions was assessed in three independent groups by the analysis of variance. The non-parametric Kraskal–Wallis test assessed those variables with abnormal distributions. Results. The I/I homozygous genotype of the angiotensin-converting enzyme gene (rs4646994) association with a decrease in the physical performance of servicemen of the Aerospace Forces of the Russian Federation was registered as 17.1 %, in particular: 9.1 % of servicemen with the I/I genotype and less than 5-year service; up to 60 % of those with the D/D genotype and more than 10-year service. The D/D genotype was found to be the most advantageous of the angiotensin-converting enzyme gene (rs4646994) genotypes studied, with less decrease in physical performance and more possibilities for long-term military service in hypoxic conditions.

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