THE VALUE OF RESTING STATE FUNCTIONAL CONNECTIVITY INDICATORS IN ASSESSMENT OF MOTOR FUNCTIONAL SYSTEM AFTER SEVERE TRAUMATIC BRAIN INJURY

The study aims to analyze the features of the functional connectivity structure of the motor system in patients after traumatic brain injury according to functional magnetic resonance imaging. Materials and methods. The study included 53 people: 40 patients with traumatic brain injury and 13 healthy people. A comprehensive clinical study was carried out, including an assessment of the patients’ neurological state and a functional magnetic resonance imaging study followed by an analysis of functional connectivity. At rest and with their eyes closed, patients underwent functional magnetic resonance imaging for 10 minutes and 12 seconds. Masks, which described the brain areas interactions, their dependence on the experimental conditions (at rest or active) and on behavior, were generated in CONN using the WFU Pick Atlas package to analyze the regions of interest connectivity. Results. The study shows that neuroplastic changes in patients include the cortical and subcortical parts of the motor functional system. The highest indicators of functional connectivity are found in the norm and mild hemiparesis. With an increase in the motor deficit, the indicators progressively decrease. The regulation of an arbitrary resting position is determined by functional connectivity of functional magnetic resonance imaging between symmetrical areas of the subcortical network (shell, globus pallidus, caudate nucleus). The study found that the most important factors in the neuroplasticity of the cerebral motor system in patients with severe traumatic brain injury are qualitative nonlinear changes in the network patterns of connectivity.

1. Лихтерман Л. Б., Кравчук А. Д., Охлопков В. А. Учение о последствиях черепно-мозговой травмы Часть I. Дефиниции, классификация, клиническая и количественно-томографическая синдромология // Клинич. разбор в общей медицине. 2021. № 5. С. 25–29. DOI 10.47407/kr2021.2.5.00067.

2. D’Souza M. M., Kumar M., Choudhary A. et al. Alterations of Connectivity Patterns in Functional Brain Networks in Patients with Mild Traumatic Brain Injury: A Longitudinal Resting-State Functional Magnetic Resonance Imaging Study // Neuroradiol J. 2020. Vol. 33, Is. 2. P. 186–197. DOI 10.1177/1971400919900275.

3. Chaban V., Clarke G. J. B., Skandsen T. et al. Systemic Inflammation Persists the First Year after Mild Traumatic Brain Injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study // J Neurotrauma. 2020. Vol. 37, Is. 19. P. 2120–2130. DOI 10.1089/neu.2020.6990.

4. Zhang J., Safar K., Emami Z. et al. Local and Large-Scale Beta Oscillatory Dysfunction in Males with Mild Traumatic Brain Injury // J Neurophysiol. 2020. Vol. 124, Is. 6. P. 1948–1958.

5. Левин О. С., Чимагомедова А. Ш. Когнитивные нарушения при черепно-мозговой травме // Современ. терапия в психиатрии и неврологии. 2019. № 2. С. 33–43.

6. Кошман И. П., Калиничев А. Г. Изолированная тяжелая черепно-мозговая травма: клиническое течение и исходы: ретроспективный анализ // Современ. проблемы науки и образования. 2021. № 1. С. 48. DOI 10.17513/spno.30518.

7. Александрова Е. В., Зайцев О. С., Потапов А. А. Клинические синдромы дисфункции нейромедиаторных систем при тяжелой травме мозга // Журн. неврологии и психиатрии им. С. С. Корсакова. 2015. Т. 115, №. 7. С. 40–46. DOI 10.17116/jnevro20151157140-46.

8. Яриков А. В., Лобанов И. А., Леонов В. А. и др. Комплексная нейровизуализация черепно-мозговой травмы: магнитно-резонансная томография // Наука и инновации в медицине. 2020. Т. 5, № 4. С. 239–244. DOI 10.35693/2500-1388-2020-5-4-239244.

9. Caeyenberghs K., Verhelst H., Clemente A., Wilson P. H. Mapping the Functional Connectome in Traumatic Brain Injury: What Can Graph Metrics Tell Us? // Neuroimage. 2017. Vol. 160. P. 113–123.

10. Shi J., Teng J., Du X., Li N. Multi-Modal Analysis of Resting-State fMRI Data in mTBI Patients and Association with Neuropsychological Outcomes // Front Neurol. 2021. Vol. 12. P. 639760.