POLYMORPHIC VARIANTS OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR GENE (RS6265) AND THEIR ASSOCIATION WITH THE SEVERITY OF COGNITIVE DYSFUNCTION IN MILITARY PERSONNEL

The study aims to evaluate the association of polymorphic variants of the brain-derived neurotrophic  factor gene (rs6265) with the severity of cognitive dysfunction in military personnel with hypoxia. Materials and methods. 295 male military personnel (100 men serving in the Arctic belt, 100 men – in the Middle belt, and 95 men – in the subtropical belt’s middle mountains), with an average age of 34, were examined. They underwent general checkup, gathering and detailing of complaints, recording of anamnesis, assessment of personal sleep characteristics. The results of the genotyping analysis of brain-derived neurotrophic factor (rs6265) were divided into three types as follows: allele1, heterozygote, and allele2. The statistical analysis of data was conducted using IBM SPSS Statistics 26. The distribution normality of quantitative indicators was assessed with Shapiro–Wilk test. The significance of differences in quantitative indicators that have normal distribution in more than two groups was assessed with the analysis of variance and Kraskal–Wallis, which is used for variables with abnormal distribution. Results. In the course of the study, statistically significant differences in the distribution of genotypes of the brainderived neurotrophic factor gene (rs6265) were registered in 295 men serving in various climatic and geographic zones (A/A – 5.76 %, G/A – 29.49 %, G/G – 64.75 %) and 100 men serving in the Arctic belt (A/A – 52.9 %, G/A – 43.7 %, G/G – 27.7 %). The study shows that the G/G gene is the most protective of the brain-derived neurotrophic factor gene (rs6265) genotypes studied and provides less cognitive dysfunction and more possibilities for longlasting military service in the Arctic conditions.

1. Панин Л. Е. Фундаментальные проблемы приполярной и арктической медицины // Бюл. Сиб. отд. Рос. акад. мед. наук. 2013. Т. 33, № 6. С. 5–10.

2. Костенко Е. В., Маневич Т. М., Разумов Н. А. Десинхроноз как один из важнейших факторов возникновения и развития цереброваскулярных заболеваний // Лечеб. дело. 2013. № 2. С. 104–116.

3. Яхно Н. Н. Когнитивные расстройства в неврологической клинике // Невролог. журн. 2006. Т. 11, № S1. С. 4–12.

4. Ковальчук В. В. Когнитивная дисфункция. Современный взгляд на этиопатогенез, диагностику и терапию // Эффектив. фармакотерапия. 2020. Т. 16, № 31. С. 40–52.

5. Gonzalez A., Moya Alvarado G., Gonzalez Billault C., Bronfman F. Cellular and Molecular Mechanisms Regulating Neuronal Growth by Brain-Derived Neurotrophic Factor // Cytoskeleton. 2016. Vol. 73, No. 10. P. 612–628.

6. Małczyńska P., Piotrowicz Z., Drabarek D., Langfort J., Chalimoniuk M. The Role of the Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Processes and in the Neuroregeneration Mechanisms Induced by Increased Physical Activity // Postepi Biochem. 2019. Vol. 65, No. 1. P. 2–8.

7. Szarowicz C. A., Steece-Collier K., Caulfield M. E. New Frontiers in Neurodegeneration and Regeneration Associated with Brain Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism // Int J Mol Sci. 2022. Vol. 23, Is. 14. P. 8011.

8. Спивак И. М., Жекалов А. Н, Глушаков Р. И. и др. Генетические корреляты креативности в экстремальных условиях Арктической зоны Российской Федерации: пилотное исследование // Обзоры по клинич. фармакологии и лекарствен. терапии. 2021. Т. 19, № 4. С. 431–442.

9. Кокаева З. Г., Кочеткова Т. О., Афончикова Е. В. Исследование полиморфизма гена нейротрофического фактора головного мозга (BDNF) у жителей Москвы // Генетика. 2013. Т. 49, № 12. С. 1432.

10. Hilsherova S., Resner P. Single Nucleotide Polymorphism p.Val66Met in the BDNF Gene in the Czech Population // Czech Slov Neurol N. 2017. Vol. 80/113, Is. 5. P. 597–600.