RADIATION-INDUCED ENDOTHELIAL DAMAGE
https://doi.org/10.34822/2304-9448-2022-4-46-53
Abstract
The study aims to review the scientific literature on the pathogenetic mechanisms of ionizing radiation damage to endotheluim during radiation therapy in cancer patients. Materials and methods. The scientific literature was searched in the Web of Science, Scopus, MEDLINE, PubMed and RSCI databases using such keywords as endothelium, radiation, and radiation therapy. The search depth was 10 years. Results. Most of the negative effects of radiation exposure are associated with the development of endothelial dysfunction. Thus, a disruption in endothelial homeostasis results in the development of a pro-inflammatory phenotype, which is followed by the inclusion of a number of pathogenetic mechanisms that cause the emergence of a variety of clinical conditions, including cardiovascular pathology. This problem occurs due to the progression of cardiovascular diseases in cancer patients, which worsens the course of the underlying disease and often leads to death. This article reviews and summarizes the latest data on the mechanisms and pathogenesis of radiationinduced endothelial damage, as well as the consequences of endothelial dysfunction. The data obtained will help develop a preventive strategy for patients undergoing radiation therapy.
About the Authors
Ilya S. Grekov
M. Gorky Donetsk National Medical University, Donetsk
Russian Federation
Russian Federation
Assistant Professor, Pathologist
Evgenii A. Seleznеv
State Budgetary Institution Amvrosievsky Central Hospital, Amvrosievka
Russian Federation
Russian Federation
Cardiologist, Radiologist
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Review
For citations:
Grekov I.S., Seleznеv E.A. RADIATION-INDUCED ENDOTHELIAL DAMAGE. Vestnik SurGU. Meditsina. 2022;(4 (54)):46-53. (In Russ.) https://doi.org/10.34822/2304-9448-2022-4-46-53
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