THE ASSESSMENT OF PHENOTYPE AND SPECIFICS OF INFLAMMATORY RESPONSE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ACUTE MYOCARDIAL INFARCTION IN DIFFERENT AGE GROUPS

The study aims to assess the phenotype and specifics of inflammatory response in myocardial infarction in patients with type 2 diabetes mellitus in different age groups. Material and methods. The study examined 121
patients with type 2 diabetes mellitus and myocardial infraction. The patients were divided into 3 clusters by the K-means clustering. The 1st cluster included 29 patient (with the age of 56.2 ± 5.3 and body mass index of 31.1 ±
4.1 kg/m2). The 2nd cluster included 48 patients (with the age of 69.0 ± 4.0 and body mass index of 30.3 ± 4.5 kg/m2). The 3rd cluster included 44 patients (with the age of 81.5 ± 4.8 and body mass index of 28.2 ± 4.8 kg/m2). Apart from the regular examination, on the 1st, 3rd, 5th and 12 ± 1 day the patients were examined for the number of monocytes, lymphocytes and their subpopulations, and neutrophils with the flow cytometry method. Results. In comparison with the 1st cluster, the patients from the 3 cluster were noticed to have lower body mass indexes (28.35 (24.69; 31.25) kg/m2 vs 31.13 (27.89; 34.11) kg/m2, p = 0.019), and lower glycated hemoglobin (6.73 (5.69; 7.54) % vs 8.42 (6.66; 10.69) %, p = 0.032). They atherogenic index was lower in comparison with the 1st and 2nd clusters: 3.45 (2.6; 4.55) vs 5.3 (4; 6.1) and 4.6 (3.5; 6.0), p = 0.003, accordingly. The patients from the 3rd cluster had lower general number of leucocytes in the 1st day than the patients from the 2nd cluster had: 8.7 (7.6; 10.6) × 109/L vs 10.95 (9; 13.4) × 109/L, p = 0.009. They lowest indexes of lymphocytes and CD16(-)T-lymphocytes and NK-cells were determined. On the 12th day CD16(+)monocytes level were higher in patients from the 3rd cluster than from the 1st cluster: 60.42 (35.445; 96.51) cells/μL vs 39.65 (25.11; 50.32) cells/μL, р = 0.039. The patients from the 2nd cluster had higher number of monocytes during the whole examination than the patients from the 1st and 3rd clusters. The patients from the 1st cluster were noticed to have the maximum of CD16(-)monocytes on the 3rd day and CD16(+)monocytes on the 5th day, in comparison with the 2nd and 3rd clusters.

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