PATHOLOGICAL ROLE OF ALLOGENIC FETAL CELLS INFILTRATING BREAST TUMOR
https://doi.org/10.34822/2304-9448-2021-3-77-82
Abstract
The study aims to determine the role of the allogenic fetal cells in the breast tumor tissue with various receptor status of tumor cells. Material and methods. Allogenic fetal cells in the tissues of the central zone of the tumor
environment were determined by the FISH method in 36 patients with newly diagnosed invasive adenocarcinoma of the mammary gland. Results. 72.2 % of women were confirmed to have allogenic fetal cells recorded in the
range from 1 to 25. The highest statistically significant (p ≤ 0.05) number of cells was found in IIB stage, with the subtype luminal B+ (hormone receptor positive and HER2+). Low (less than 10 %) lymphocyte infiltration was found
in all patients’ central zone of the tumor, in the area of the fetal cells. However, the lowest statistically significant (p ≤ 0.05) indicator was obtained in one of the most adverse course subtype luminal B+ HER2+, in the group
of women with diagnosed fetal cells. A linear correlation was noted between the number of allogenic cells and lymphocytes in the same patients, which additionally indicates a decrease in the immunological activity of tissues
and a prognostic adverse outcome in treatment and remission.
About the Authors
E. V. Bubovich
Surgut State University, Surgut
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Associate Professor, Department of General Pathology and Pathophysiology, Medical Institute
SPIN: 5577-5585.
Е-mail: bubovichev@gmail.com.
V. M. Abunagimov
Surgut Regional Clinical Hospital, Surgut
Russian Federation
Russian Federation
Head, Oncology Department of Mammology
Е-mail: avm777@my.com
V. V. Vagina
Surgut Regional Clinical Hospital, Surgut
Russian Federation
Russian Federation
Geneticist, Clinical and Diagnostic Laboratory
Е-mail: bubovichev@gmail.com
A. A. Ibraginbekova
Surgut State University, Surgut
Russian Federation
Russian Federation
Student, Medical Institute
Е-mail: ibraginbekowa@yandex.ru
V. E. Viduto
Surgut Regional Clinical Hospital, Surgut
Russian Federation
Russian Federation
Pathologist, Department of Morbid Anatomy
Е-mail: ikar-malikova@ya.ru
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Review
For citations:
Bubovich E.V., Abunagimov V.M., Vagina V.V., Ibraginbekova A.A., Viduto V.E. PATHOLOGICAL ROLE OF ALLOGENIC FETAL CELLS INFILTRATING BREAST TUMOR. Vestnik SurGU. Meditsina. 2021;(3 (49)):77-82. (In Russ.) https://doi.org/10.34822/2304-9448-2021-3-77-82
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