PREDICTIVE POTENTIAL OF SUPEROXIDE DISMUTASE AND GLUTATHIONE FOR THE DIAGNOSIS OF THE CENTRAL NERVOUS SYSTEM INJURY IN PREMATURE INFANTS

The study aims to assess the predictive potential of superoxide dismutase (SOD) and glutathione for the diagnosis of severe damage of the central nervous system in premature infants. Material and methods. The main group of the study is premature newborns with gestational age less than 36 weeks inclusive (n = 60), the control group – full-term newborns (n = 25). In the process of dynamic observation, the main group was divided into subgroups depending on the diagnosed central nervous system injury in the neonatal period, according to the data of instrumental methods of examination (intraventricular hemorrhages of varying severity, periventricular leukomalacia): subgroup 1 (prematurity with central nervous system injury) – 25 people, subgroup 2 (premature babies without central nervous system injury) – 35 people. A study of oxidative stress, antioxidant capacity, blood levels of enzymes Cu,Zn-SOD, Mn-SOD and glutathione in the early neonatal period was carried out. Results. Premature newborns differ in the level of antioxidant protection and children with lower indicators of antioxidant status are prone to the development of severe organic damage of the central nervous system in the neonatal period. There were no significant differences in studied parameters between full-term and premature infants without
central nervous system injury. Cu,Zn-SOD and glutathione can be used in clinical practice as predictors of organic damage of the central nervous system.

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