BIOMARKERS OF CARDIAC SURGERY-ASSOCIATED ACUTE KIDNEY INJURY
https://doi.org/10.34822/2304-9448-2021-3-61-70
Abstract
The study aims to review the scientific literature devoted to the diagnostic and prognostic significance of various biomarkers in patients with acute kidney injury after cardiac surgery. Material and methods. The scientific
literature was searched in the following databases: Web of Science, Scopus, MEDLINE, PubMed and RSCI. The keywords: acute kidney injury, biomarkers, cardiac surgery. The search depth is 10 years. Results. The possibility of
using standard criteria for the diagnosis of renal damage, based on the measuring of the amount of urine output and the concentration of serum creatinine, does not satisfy the possibility to verify the pathology at the subclinical stage, since an increase in the latter can occur only after significant damage of the renal structures. Considering these aspects, attempts have been made to search for more sensitive and specific biomarkers of renal damage. The study discusses the problem of using the definition “acute kidney injury” in the context of diagnosis, considers the possibilities and basic requirements for the use of biomarkers in clinical practice, and also presents the values of some of the main markers of acute renal damage (NGAL, FABP1, calprotectin and KIM-1).
About the Author
I. S. Grekov
M. Gorky Donetsk National Medical University;
Donetsk Clinical Territorial Medical Association, Donetsk.
Russian Federation
Russian Federation
Pathologist
Е-mail: ilya.grekov.1998@gmail.com
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Review
For citations:
Grekov I.S. BIOMARKERS OF CARDIAC SURGERY-ASSOCIATED ACUTE KIDNEY INJURY. Vestnik SurGU. Meditsina. 2021;(3 (49)):61-70. (In Russ.) https://doi.org/10.34822/2304-9448-2021-3-61-70
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