Preview

Vestnik SurGU. Meditsina

Advanced search

THE PROBLEM OF THIN ENDOMETRIUM IN THE IN VITRO FERTILIZATION CYCLES

https://doi.org/10.34822/2304-9448-2020-4-63-67

Abstract

The study aims to review scientific literature to determine the concept of thin endometrium, search for the causes of the appearance, the main diagnostic methods, and possible ways to correct the thickness of the endometrium. Material and methods. The works of foreign and Russian authors are studied: randomized controlled trials, systematic reviews, and guidelines. The data is collected from PubMed, eLIBRARY.RU, CyberLeninka, and other databases. The keywords in the search are thin endometrium, endometrial thickness, endometrium, receptivity, infertility. The search depth is six years. Results. Тhere is no clear definition for the thin endometrium, given that for different authors the thickness varies from 7 to 10 mm. Risk factors for the development of a thin endometrium are inflammatory diseases of the pelvic organs and their irradiation, trauma during curettage of the uterine cavity, impaired blood supply, postpartum endometritis, adhesions, septic abortion, the use of clomiphene citrate, hypogonadotropic hypogonadism, premature ovarian failure. The main diagnostic method is a transvaginal ultrasound. Currently, none of the methods for correcting the thickness of the endometrium has proven its effectiveness and none is recommended for use. Therefore, the problem remains and it is actively studied.

About the Authors

M. V. Pavlova
Research Institute of Obstetrics, Gynecology and Reproductology named after D. O. Ott, Saint Petersburg
Russian Federation

Medical Resident, Obstetrician-gynaecologist,

E-mail: mv.pavlova@list.ru



N. I. Tapilskaya
Research Institute of Obstetrics, Gynecology and Reproductology named after D. O. Ott, Saint Petersburg
Russian Federation

Doctor of Sciences (Medicine), Professor, Leading Researcher,

E-mail: tapnatalia@yandex.ru

 



References

1. Регистр ВРТ. Отчет РАРЧ за 2018 год. URL: http://www.rahr.ru/d_registr_otchet/RegistrART2018.pdf (дата обращения: 15.09.2020).

2. The ESHRE Guideline Group on Ovarian Stimulation, Bosch E., Broer S., Griesinger G. et al. ESHRE Guideline: Ovarian Stimulation for IVF/ICSI // Human Reproduction Open. 2020. Vol. 2020, Iss. 2. DOI 10.1093/hropen/hoaa009.

3. Кузнецова И. А., Землина Н. С., Рашидов Т. Н., Коваленко М. А. Проблема тонкого эндометрия и возможные пути ее решения // Эффектив. фармакотерапия. 2015. № 5. С. 42–49.

4. Jing Z., Qiong Z., Yonggang W., Yanping L. Rat Bone Marrow

5. Mesenchymal Stem Cells Improve Regeneration of Thin

6. Endometrium in Rat // Fertil Steril. 2014. № 101 (2). Р. 587–594.

7. DOI 10.1016/j.fertnstert.2013.10.053.

8. Maekawa R., Taketani T., Mihara Y., Sato S. et al. Thin Endometrium Transcriptome Analysis Reveals a Potential Mechanism of Implantation Failure // Reprod Med Biol. 2017. № 16 (2). P. 206–227.

9. Maleki-Hajiagha A., Razavi M., Rouholamin S., Rezaeinejad M., Maroufizadeh S., Sepidarkish M. Intrauterine Infusion of Autologous Platelet-Rich Plasma in Women Undergoing Assisted Reproduction: A Systematic Review and Meta-Analysis // J Reprod Immunol. 2020. Vol. 137. DOI 10.1016/j.jri.2019.103078.

10. Timeva T., Shterev A., Kyurkchiev S. Recurrent Implantation Failure: the Role of the Endometrium // J Reprod Infertil. 2014. № 15. P. 173–183.

11. Kasius A., Smit J. G., Torrance H. L., Eijkemans M. J. et al. Endometrial Thickness and Pregnancy Rates after IVF: a Systematic Review and Meta-Analysis // Hum Reprod Update. 2014. № 20 (4). P. 530–541. DOI 10.1093/humupd/dmu011.

12. Серова О. Ф., Седая Л. В., Шутикова Н. В., Соваев Н. И., Елисеев Э. Н. Морфофункциональное состояние тонкого эндометрия и возможности его коррекции // Лечение и профилактика. 2015. № 2. С. 10–14.

13. Mahajan N., Sharma S. The Endometrium in Assisted Reproductive Technology: How Thin is Thin? // J Hum Reprod Sci. 2016. № 9 (1). P. 3–8. DOI 10.4103/0974-1208.178632.

14. Weiss N. S., van Vliet M. N., Limpens J., Hompes P. G. A. et a. Endometrial Thickness in Women Undergoing IUI with Ovarian Stimulation. How Thick is too Thin? A Systematic Review and Meta-Analysis // Human Reproduction. 2017. Vol. 32, Iss. 5. P. 1009–1018.

15. Liu K. E., Hartman M., Hartman A. Management of Thin Endometrium in Assisted Reproduction: A Clinical Practice Guideline from the Canadian Fertility and Andrology Society // Reprod Biomed Online. 2019. № 39 (1). P. 49–62. DOI 10.1016/j.rbmo.2019.02.013.

16. Rocha M. N. C., Florêncio R. S., Alves R. R. F. The Role Played by Granulocyte Colony Stimulating Factor (G-CSF) on Women Submitted to In Vitro Fertilization Associated with Thin Endometrium: Systematic Review // JBRA Assist Reprod. 2020.

17. № 24 (3). P. 278–282. DOI 10.5935/1518-0557.20200025.

18. Salmassi A., Schmutzler A. G., Schaefer S., Koch K., Hedderich J., Jonat W., Mettler L. Is Granulocyte Colony-Stimulating Factor Level Predictive for Human IVF Outcome? // Hum Reprod. 2005. № 20. P. 2434–2440. DOI 10.1093/humrep/dei071.

19. Kunicki M., Łukaszuk K., Woclawek-Potocka I., Liss J., Kulwikowska P., Szczyptańska J. Evaluation of Granulocyte Colony-Stimulating Factor Effects On Treatment-Resistant Thin Endometrium in Women Undergoing In Vitro Fertilization // Biomed Res Int. 2014. DOI 10.1155/2014/913235.

20. Gleicher N., Vidali A., Barad D. H. Successful Treatment of

21. Unresponsive Thin Endometrium // Fertil Steril. 2011. № 95. P. e13–e17. DOI 10.1093/humrep/des370. 2123

22. Frantz N, Ferreira M, Kulmann MI, Frantz G, Bos-Mikich A, Oliveira R. Platelet-Rich Plasma as an Effective Alternative Approach for Improving Endometrial Receptivity – A Clinical Retrospective Study // JBRA Assist Reprod. 2020. DOI 10.5935/1518-0557.20200026.

23. Kim H., Shin J. E., Koo H. S., Kwon H., Choi D. H., Kim J. H. Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study // Front Endocrinol (Lausanne). 2019. DOI 10.3389/ fendo.2019.00061.

24. Azizi R., Aghebati-Maleki L., Nouri M., Marofi F., Negargar S.,Yousefi M. Stem Cell Therapy in Asherman Syndrome and Thin Endometrium: Stem Cell-based Therapy // Biomed Pharmacother. 2018. № 102. P. 333–343. DOI 10.1016/j.biopha.2018.03.091.

25. Краснопольская К. В., Назаренко Т. А., Федоров А. А., Ершова И. Ю. Влияние на эффективность ЭКО эндометриального скретчинга, назначаемого пациенткам с ультразвуковыми признаками экстремально «тонкого» эндометрия // Мед. алфавит. 2016. № 3. С. 39–43.

26. Barash A., Dekel N., Fieldust S., Segal I., Schechtman E., Granot I. Local Injury To The Endometrium Doubles The Incidence Of Suc-cessful Pregnancies In Patients Undergoing In Vitro Fertilization // Fertil Steril. 2003. № 79 (6). P. 1317–1322. DOI 10.1016/s0015-0282(03)00345-5.

27. Van Hoogenhuijze N. E., Kasius J. C., Broekmans F. J. M., Bosteels J., Torrance H. L. Endometrial Scratching Prior to IVF; Does it Help and for Whom? A Systematic Review and Meta-Analysis // Hum Reprod Open. 2019. № 1. DOI 10.1093/hropen/hoy025.


Review

For citations:


Pavlova M.V., Tapilskaya N.I. THE PROBLEM OF THIN ENDOMETRIUM IN THE IN VITRO FERTILIZATION CYCLES. Vestnik SurGU. Meditsina. 2020;(4 (46)):63-67. (In Russ.) https://doi.org/10.34822/2304-9448-2020-4-63-67

Views: 337


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2949-3447 (Online)