PARADOXES OF REPERFUSION IN THE PRACTICE OF CRITICAL CONDITIONS: POSSIBLE SOLUTION
https://doi.org/10.34822/2304-9448-2020-3-69-75
Abstract
The study aims to clarify the pathogenetic factors of ischemia/reperfusion syndrome in critical conditions. Material and methods. The 122 open scientific publications in Pubmed, Medline, Embase, and e-Library.ru databases are analyzed. Data from 44 articles are included in the study. Results. The review presents modern literary data on ischemia/reperfusion syndrome, clarifying pathogenetic factors that determine the main damaging determinants. The authors draw attention to the factors influencing the severity of reperfusion damage, with an emphasis on the role of the oxygen paradox of reperfusion, potentiating free-radical oxidation in the presence of free iron ions, and damage to the respiratory chain of mitochondria. These factors, according to research, are the basis of the development of endothelial dysfunction, which causes the formation of multiple organ dysfunction syndrome in a number of critical conditions.
About the Authors
A. V. Kolyadko
Nizhnevartovsk Regional Clinical Hospital, Nizhnevartovsk
Russian Federation
Anaesthesiologist-reanimatologist
Russian Federation
Anaesthesiologist-reanimatologist
Ye. A. Lang
Omsk City Clinical Hospital № 1 n. a. A. N. Kabanov, Omsk
Russian Federation
Anaesthesiologist-reanimatologist
Russian Federation
Anaesthesiologist-reanimatologist
N. V. Govorova
Omsk State Medical University, Omsk
Russian Federation
Doctor of Sciences (Medicine), Professor, Head, Anesthesiology and Reanimation
Department
Russian Federation
Doctor of Sciences (Medicine), Professor, Head, Anesthesiology and Reanimation
Department
T. V. Boyko
Omsk State Agrarian University named after P. A. Stolypin, Omsk
Russian Federation
Doctor of Sciences (Veterinary), Professor, Head, Department of Diagnostics, Internal Non-Infectious Diseases, Pharmacology, Surgery and Obstetrics, Faculty of Veterinary Medicine
Russian Federation
Doctor of Sciences (Veterinary), Professor, Head, Department of Diagnostics, Internal Non-Infectious Diseases, Pharmacology, Surgery and Obstetrics, Faculty of Veterinary Medicine
Yu. P. Orlov
Omsk State Medical University, Omsk
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor of the Department of Anesthesiology and Emergency Medicin;
Е-mail: orlov-up@mail.ru
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Review
For citations:
Kolyadko A.V., Lang Ye.A., Govorova N.V., Boyko T.V., Orlov Yu.P. PARADOXES OF REPERFUSION IN THE PRACTICE OF CRITICAL CONDITIONS: POSSIBLE SOLUTION. Vestnik SurGU. Meditsina. 2020;(3 (45)):69-75. (In Russ.) https://doi.org/10.34822/2304-9448-2020-3-69-75
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