CYTOPROTECTIVE POTENTIAL IN POLYPHENOLIC EXTRACTS OF VACCINIUM FRUITS GROWING IN THE UGRA TERRITORY IN VITRO
https://doi.org/10.34822/2304-9448-2020-1-86-93
Abstract
The aim of the study is to assess the potential cytoprotective properties of extracts in northern berries: common cranberries (Vaccinium oxycoccus L.), bilberries (Vaccinium myrtillus L.), lingonberries (Vaccinium vitis-idaea L.) and blueberries (Vaccinium uliginosum L.) on cell cultures in vitro. Material and methods. For the extracts of these fruits quantitative composition of the main groups of polyphenols is characterized and the level of antiradical activity in the ABTS test is determined. The study results of the effects on cell viability of extracts in the cytotoxicity test are described. Results. It is established that in the primary culture of rabbit alveolar macrophages and the passaged culture of human embryonic kidney cells (HEK293), the studied extracts do not possess own cytotoxicity and prevent the development of the cytotoxic effect of doxorubicin but possess cytoprotective potential.
About the Authors
E. A. Belova
Surgut State University, Surgut, Russia
Russian Federation
Assistant Professor, Department of Pathophysiology and General Pathology, Medical Institute
Russian Federation
Assistant Professor, Department of Pathophysiology and General Pathology, Medical Institute
E. A. Krivykh
Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russia
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Docent, Head, Department of Public Health and Healthcare;
Е-mail: KrivyhEA@hmgma.ru
N. S. Kavushevskaya
Surgut State University, Surgut, Russia
Russian Federation
Russian Federation
Candidate of Sciences (Biology), Senior Lecturer, Department of Pathophysiology and General Pathology;
Е-mail: natalya.kavushevskaya@mail.ru
L. K. Bystrevskaya
Karaganda Medical University, Karaganda, Republic of Kazakhstan
Kazakhstan
Professor of the Department of Pathology
Kazakhstan
Professor of the Department of Pathology
S. B. Zhautikova
Некоммерческое акционерное общество «Медицинский университет Караганды», Республика Казахстан
Kazakhstan
Kazakhstan
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Review
For citations:
Belova E.A., Krivykh E.A., Kavushevskaya N.S., Bystrevskaya L.K., Zhautikova S.B. CYTOPROTECTIVE POTENTIAL IN POLYPHENOLIC EXTRACTS OF VACCINIUM FRUITS GROWING IN THE UGRA TERRITORY IN VITRO. Vestnik SurGU. Meditsina. 2020;(1 (43)):86-93. (In Russ.) https://doi.org/10.34822/2304-9448-2020-1-86-93
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