DYNAMICS OF SERUM CYTOKINES AS AN INDICATOR OF INFLAMMATION EXPRESSION IN PATIENTS AFTER LUNGS RESECTION

The aim of the study is to take a comparative assessment of the inflammation severity in patients with
lung neoplasms based on changes in the concentration of interleukins in serum during surgery and in the early postoperative period in the presence of various types of anaesthesia and analgesia. Material and methods. Twentyfour patients aged 45 to 50 years divided into the main group and the comparison group are examined. In the main group, multimodal anaesthesia-analgesia with elements of a sympathetic blockade is used both during the surgery and in the postoperative period. The inhaled-intravenous anaesthesia followed by systemic analgesia with morphine is used in the comparison group. Four research points are identified: before induction of anaesthesia, 1, 12, and 24 hours after surgery. Results. In the postoperative period, patients undergoing lungs resection have statistically significant changes in the concentration of the studied cytokines, which indicates the presence of inflammation. The severity of the inflammatory process in the postoperative period using different methods of anaesthesia varies. In patients who had the sympathetic blockade in anaesthesia-analgesia regimens, inflammation is more evident

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