CYSTOGENESIS: CELLULAR AND MOLECULAR MECHANISMS OF PATHO- AND MORPHOGENESIS
https://doi.org/10.34822/2304-9448-2020-1-59-65
Abstract
The aim of the study is to analyze modern ideas about patho- and morphogenesis, morphogenetic potencies and the significance of cyst formation for pathology. Material and methods. A literature search has been conducted using the following databases: CyberLeninka, eLIBRARY.RU, PubMed, Nature Pathology, MEDLINE, PLOS ONE. The search includes only fundamental works for the last 7–10 years. Keywords used in the search are cystogenesis, patho- and morphogenesis of cyst formation, epithelial morphogenesis, epithelial-stromal interactions. Results. In recent years, cystogenesis is viewed not only as the most important phenomenon of epithelial morphogenesis, which is of great importance in physiological and reparative regeneration but also as the process that makes up the morphological essence of many diseases (polycystic kidney disease, nonneoplastic cysts of the central nervous system, etc.), as well as the outcome of chronic processes in many organs, increasing the risk of tumour transformation. This determines the interest in both the mechanisms of cyst formation and the discovery of the biological potencies of the process. The disorder of cell polarity and changes in the qualitative composition of the extracellular matrix are considered the most important morphogenetic mechanism of cyst formation. In the genesis of cysts, both hereditary and acquired gene mutations are important, as well as epigenetic effects, causing a violation of epithelial-stromal interactions. It is believed that cystogenesis is associated with abnormalities in the Wnt-pathway, the most important signaling cell pathway, which is involved in the development of cancer (in particular, stomach cancer), and embryonic morphogenesis, the formation of cell polarity and cystogenesis. At the same time, the interaction between many signaling pathways of the cell in cyst formation, as well as the connection between cystogenesis and tumour growth, remains unclear
Keywords
cystogenesis,
patho- and morphogenesis of cyst formation,
epithelial morphogenesis,
epithelial-stromal interaction
Supporting agencies: CYSTOGENESIS: CELLULAR AND MOLECULAR MECHANISMS OF PATHO- AND MORPHOGENESIS
About the Author
L. A. Naumova
Surgut State University, Surgut, Russiа
Russian Federation
Russian Federation
Doctor of Sciences (Medicine), Professor of the Department of Pathophysiology and General Pathology, Medical Institute;
E-mail: naumovala@yandex.ru
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Review
For citations:
Naumova L.A. CYSTOGENESIS: CELLULAR AND MOLECULAR MECHANISMS OF PATHO- AND MORPHOGENESIS. Vestnik SurGU. Meditsina. 2020;(1 (43)):59-65. (In Russ.) https://doi.org/10.34822/2304-9448-2020-1-59-65
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