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MODERN VIEW ON THE TREATMENT PROBLEM OF GESTATIONAL DIABETES

https://doi.org/10.34822/2304-9448-2020-1-49-58

Abstract

The aim of the study is to analyze modern approaches to the treatment of gestational diabetes mellitus.
Material and methods. The analysis of domestic and foreign publications, randomized controlled trials, and clinical practice guidelines for the last 7 years from various sources is conducted. Results. The review presents the current state of various approaches and methods of treatment for gestational diabetes mellitus. Lifestyle modification, dietary intervention and insulin therapy remain the main correction methods of carbohydrate metabolism disorders during pregnancy. Further research is needed to clarify the safety and efficacy of oral antihyperglycemic medications for female patients of this cohort.

About the Authors

L. D. Belotserkovtseva
Surgut State University, Surgut Regional Clinical Prenatal Centre, Surgut, Russia
Russian Federation

Doctor of Sciences (Medicine), Professor, Head, Department of Obstetrics, Gynecology and Perinatology, Medical Institute,

Chief Medical Officer;

Е-mail: info@surgut-kpc.ru



L. V. Kovalenko
Surgut State University, Surgut, Russia
Russian Federation

Doctor of Sciences (Medicine), Professor, Head, Department of Pathophysiology and General Pathology, Director, Medical Institute;

Е-mail: lvkhome@yandex.ru



I. Y. Dobrynina
Surgut State University, Surgut, Russia
Russian Federation

Doctor of Sciences (Medicine), Professor of the Internal Diseases Department, Medical Institute;

Е-mail: diu_surgut@mail.ru



E. N. Konchenkova
Surgut State University, Surgut, Russia
Russian Federation

Candidate of Sciences (Medicine), Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Medical Institute;

Е-mail: een79@yandex.ru



References

1. International Diabetes Federation. The IDF Diabetes Atlas

2. Seventh Edition 2015 provides the latest national, regional

3. and global data on diabetes. URL: http://www.diabetesatlas.

4. org/ (дата обращения: 21.04.2019).

5. Гестационный сахарный диабет : клинич. рекомендации

6. МЗ РФ, 2016. 27 с.

7. Добрынина И. Ю., Карпин В. А. Заболеваемость сахарным

8. диабетом в Ханты-Мансийском автономном округе –

9. Югре // Вестник СурГУ. Медицина. 2018. № 1. С. 51–55.

10. Алгоритмы специализированной медицинской помощи

11. больным сахарным диабетом / под ред. И. И. Дедова,

12. М. В. Шестаковой, А. Ю. Майорова. 9-й вып. (дополненный).

13. М., 2019. 212 с.

14. Feghali M. N., Scifres C. M. Novel Therapies for Diabetes

15. Mellitus in Pregnancy // BMJ. 2018. P. 362. DOI 10.1136/bmj.

16. k2034.

17. Сазонова А. И., Есаян Р. М., Колегаева О. И., Гарданова Ж. Р.

18. Эффективность и безопасность применения препара-

19. тов метформина при беременности для лечения гестационного сахарного диабета: современный взгляд на

20. проблему // Сахарный диабет. 2016. № 19 (2). С. 164–170.

21. Hod M., Kapur A., Sacks D. A. et al. The International Federation

22. of Gynecology and Obstetrics (FIGO) Initiative on

23. Gestational Diabetes Mellitus: A Pragmatic Guide for Diagnosis,

24. Management, and Care // Int J Gynaecol Obstet.

25. No. 131. Supp. l3. P. 173–211. DOI 10.1016/S0020-

26. (15)30033-3.

27. American Diabetes Association. Standards of Medical Care

28. in Diabetes – Classification and Diagnosis of Diabetes // Diabetes

29. Care. 2015. No. 38. Suppl. 1. P. 8–16.

30. Russo L. M., Nobles C., Ertel K. A., Chasan-Taber L., Witcomb B. W.

31. Physical Activity Interventions in Pregnancy and Risk of

32. Gestational Diabetes Mellitus: a Systematic Review and Meta-

33. analysis // Obstet Gynecol. 2015. No. 125 (3). P. 576–582.

34. Bao W., Tobias D. K., Bowers K., Chavarro J., Vaag A., Grunnet L. G.

35. et al. Physical Activity and Sedentary Behaviors Associated

36. with Risk of Progression from Gestational Diabetes Mellitus

37. to Type 2 Diabetes Mellitus: a Prospective Cohort Study //

38. JAMA Intern Med. 2014. No. 174 (7). P. 1047–1055.

39. Moreno-Castilla C., Hernandez M., Bergua M. et al. Low-carbohydrate

40. Diet for the Treatment of Gestational Diabetes

41. Mellitus: a Randomized Controlled Trial // Diabetes Care.

42. No. 36. P. 2233–2238.

43. Hernandez T. L., Van Pelt R. E., Anderson M. A. et al. A Higher-

44. complex Carbohydrate Diet in Gestational Diabetes Mellitus

45. Achieves Glucose Targets and Lowers Postprandial Lipids:

46. a Randomized Crossover Study // Diabetes Care. 2014.

47. No. 37. P. 1254–1262.

48. Hernandez T. L., Van Pelt R. E., Anderson M. A. et al. Women

49. with Gestational Diabetes Mellitus Randomized to

50. a Higher-complex Carbohydrate/Low-fat Diet Manifest

51. Lower Adipose Tissue Insulin Resistance, Inflammation,

52. Glucose, and Free Fatty Acids: a Pilot Study // Diabetes

53. Care. 2016. No. 39. P. 39–42.

54. Toledano Y., Hadar E., Hod M. Safety of Insulin Analogues

55. as Compared with Human Insulin in Pregnancy // Expert

56. Opin Drug Saf. 2016. No. 15. P. 963–973.

57. Milluzzo A., Tumminia A., Scalisi N. M., Frittitta L., Vigneri R.,

58. Sciacca L. Insulin Degludec in the First Trimester of Pregnancy:

59. Report of Two Cases // J Diabetes Investig. 2017.

60. DOI 10.1111/jdi.12721.

61. Ranasinghe P. D., Maruthur N. M., Nicholson W. K. et al.

62. Comparative Effectiveness of Continuous Subcutaneous

63. Insulin Infusion Using Insulin Analogs and Multiple Daily

64. Injections in Pregnant Women with Diabetes Mellitus: a

65. Systematic Review and Meta-analysis // J Womens Health

66. (Larchmt). 2015. No. 24. P. 237–249.

67. Feig D. S., Donovan L. E., Corcoy R. et al. Continuous Glucose

68. Monitoring in Pregnant Women with Type 1 Diabetes

69. (CONCEPTT): a Multicentre International Randomised

70. Controlled Trial // Lancet. 2017. No. 390. P. 2347–2359.

71. Moy F. M., Ray A., Buckley B. S., West H. M. Techniques of

72. Monitoring Blood Glucose During Pregnancy for Women

73. with Pre-existing Diabetes // Cochrane Database Syst Rev.

74. No. 6. DOI 10.1002/14651858.CD009613.pub3.

75. O’Neill S. M., Kenny L. C., Khashan A. S., West H. M., Smyth R. M.,

76. Kearney P. M. Different Insulin Types and Regimens for

77. Pregnant Women with Pre-existing Diabetes // Cochrane

78. Database Syst Rev. 2017. No. 2. DOI 10.1002/14651858.

79. CD011880.pub2.

80. Balsells M., García-Patterson A., Solà I., Roqué M., Gich I.,

81. Corcoy R. Glibenclamide, Metformin, and Insulin for the

82. Treatment of Gestational Diabetes: a Systematic Review

83. and Meta-analysis // BMJ. 2015. No. 350. DOI 10.1136/bmj.

84. h102.

85. Farrar D., Simmonds M., Bryant M., et al. Treatments

86. for Gestational Diabetes: a Systematic Review and

87. Meta-analysis // BMJ Open. 2017. No. 7. DOI 10.1136/

88. bmjopen-2016-015557.

89. Butalia S., Gutierrez L., Lodha A., Aitken E., Zakariasen A.,

90. Donovan L. Short- and Long-term Outcomes of Metformin

91. Compared with Insulin Alone in Pregnancy: a Systematic

92. Review and Meta-analysis // Diabet Med. 2017. No. 34.

93. P. 27–36.

94. Ainuddin J. A., Karim N., Zaheer S., Ali S. S., Hasan A. A.

95. Metformin Treatment in Type 2 Diabetes in Pregnancy: an

96. Active Controlled, Parallel-group, Randomized, Open Label

97. Study in Patients with Type 2 Diabetes in Pregnancy // J

98. Diabetes Res. 2015. 11 p.

99. Ibrahim M. I., Hamdy A., Shafik A., Taha S., Anwar M., Faris M.

100. The Role of Adding Metformin in Insulin-resistant Diabetic

101. Pregnant Women: a Randomized Controlled Trial // Arch

102. Gynecol Obstet. 2014. No. 289. P. 959–965.

103. Chiswick C., Reynolds R.M., Denison F. et al. Effect of

104. Metformin on Maternal and Fetal Outcomes in Obese Pregnant Women (EMPOWaR): a Randomised, Doubleblind, Placebo-controlled Trial // Lancet Diabetes Endocrinol. 2015. No. 3. P. 778–786.

105. Syngelaki A., Nicolaides K. H., Balani J. et al. Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus // N Engl J Med. 2016. No. 374. P. 434–443.

106. Ijäs H., Vääräsmäki M., Saarela T., Keravuo R., Raudaskoski T. A

107. Follow-up of a Randomised Study of Metformin and Insulin in Gestational Diabetes Mellitus: Growth and Development of the Children at the Age of 18 Months // BJOG. 2015. No. 122. P. 994–1000.

108. Hanem L. G. E., Stridsklev S., Júlíusson P. B. et al. Metformin

109. Use in PCOS Pregnancies Increases the Risk of Offspring Overweight at 4 Years of Age; Follow-up of Two RCTs // J Clin Endocrinol Metab. 2018. No. 103. P. 1612–1621.

110. Tartarin P., Moison D., Guibert E. et al. Metformin Exposure

111. Affects Human and Mouse Fetal Testicular Cells // Hum Reprod. 2012. No. 27 (11). P. 3304–3314.

112. Camelo Castillo W., Boggess K., Stürmer T., Brookhart M. A.,

113. Benjamin D. K. Jr., Jonsson Funk M. Association of Adverse

114. Pregnancy Outcomes with Glyburide vs Insulin in Women with Gestational Diabetes // JAMA Pediatr. 2015. No. 169. P. 452–458.

115. Díaz P., Dimasuay K. G., Koele-Schmidt L. et al. Glyburide

116. Treatment in Gestational Diabetes is Associated with Increased Placental Glucose Transporter 1 Expression and Higher Birth Weight // Placenta. 2017. No. 57. P. 52–59.

117. DʼAnna R., Di Benedetto A., Scilipoti A. et al. Myo-inositol

118. Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women: a Randomized Controlled Trial // Obstet Gynecol. 2015. No. 126. P. 310–315.

119. Farren M., Daly N., McKeating A., Kinsley B. Turner M. J., Daly S.

120. The Prevention of Gestational Diabetes Mellitus with Antenatal Oral Inositol Supplementation: a Randomized Controlled Trial // Diabetes Care. 2017. No. 40. P. 759–763.

121. Facco F. L., Parker C. B., Reddy U. M. et al. Association Between Sleep-disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus // Obstet Gynecol. 2017. No. 129. P. 31–41.


Review

For citations:


Belotserkovtseva L.D., Kovalenko L.V., Dobrynina I.Y., Konchenkova E.N. MODERN VIEW ON THE TREATMENT PROBLEM OF GESTATIONAL DIABETES. Vestnik SurGU. Meditsina. 2020;(1 (43)):49-58. (In Russ.) https://doi.org/10.34822/2304-9448-2020-1-49-58

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