PROSPECTS OF APPLYING THE POLYGENIC RISK SCORES (PRS) TO ESTIMATE THE RISK OF BREAST CANCER DEVELOPMENT
https://doi.org/10.1234/10.34822/2304-9448-2019-4-74-78
Abstract
The aim of the study is to determine the position of the genome-wide association study as a method associated with a risk increase of breast cancer development in the clinical practice. Material and methods. The literature search is conducted in the PubMed, Scopus, Cochrane Database of Systematic Reviews and other databases. The keywords used for the search are breast cancer, genome-wide association study (GWAS), polygenic risk score. The search depth is 10 years. Results. Breast cancer is the most common oncological disease in women worldwide. For the identification of genetic variants, causing breast cancer, it is possible to use the genome-wide association study. Furthermore, the search data allows composing polygenic risk scores, dividing women into groups for treatment and choosing preventive measures that are most effective for each particular type of cancer.
About the Authors
N. V. Smirnova
Moscow State Academy of Fine Chemical Technology named after M. V. Lomonosov
Russian Federation
Russian Federation
Master of Science
e-mail: smirnova10nv@gmail.com
A. U. Elmuratov
Institute of Biomedical Chemistry, Moscow; Genotek LLC, Moscow
Russian Federation
Russian Federation
Researcher
e-mail: artem@genotek.ru
RSCI ID: 928632
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Review
For citations:
Smirnova N.V., Elmuratov A.U. PROSPECTS OF APPLYING THE POLYGENIC RISK SCORES (PRS) TO ESTIMATE THE RISK OF BREAST CANCER DEVELOPMENT. Vestnik SurGU. Meditsina. 2019;(4 (42)):74-78. (In Russ.) https://doi.org/10.1234/10.34822/2304-9448-2019-4-74-78
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