HEREDITARY THROMBOPHILIA DURING COMPLICATED COURSEOF PREGNANCY AND ADVERSE PREGNANCY OUTCOMES
https://doi.org/10.34822/2304-9448-2019-4-66-73
Abstract
The aim of the study is to analyze the contemporary literature to determine the prevalence of complicated course and adverse pregnancy outcomes with gene polymorphisms of the blood coagulation system. Material and methods. The analysis of literary sources in the Cochrane, PubMed, eLIBRARY and Scopus databases for the last 10 years is carried out. The search is conducted by keywords: adverse pregnancy outcomes, thrombophilia, polymorphisms, miscarriage, intrauterine growth retardation, intrauterine fetal death, premature detachment of a normally located placenta, etc. Results. The prevalence of gene polymorphisms of hemostasis varies in European and Asian populations. It is still unclear why some carriers of thrombophilic genes experience complications, while others do not. A more systematic approach to the study is necessary, taking into account anamnesis, comorbid background, lifestyle, etc. Gene polymorphisms of blood coagulation are likely to have some ethnic specificity, which is of particular interest in such a multinational state as the Russian Federation.
About the Authors
L. D. Belotserkovtseva
Surgut State University;
Surgut Regional Clinical Prenatal Centre
Russian Federation
Russian Federation
Honored Doctor of the Russian Federation, Doctor of Science (Medicine), Professor, Head, Department of Obstetrics, Gynecology and Perinatology Medical Institute; Officer
e-mail: ag_kpc@admsurgut.ru
T. I. Isaev
Surgut State University
Russian Federation
Russian Federation
Anaesthesiologist-reanimatologist, Postgraduate, Medical Institute
e-mail: tarlasha777@mail.ru
L. V. Kovalenko
Surgut State University
Russian Federation
Russian Federation
Doctor of Science (Medicine), Head, Department of Pathophysiology and General Pathology, Director, Medical Institute
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For citations:
Belotserkovtseva L.D., Isaev T.I., Kovalenko L.V. HEREDITARY THROMBOPHILIA DURING COMPLICATED COURSEOF PREGNANCY AND ADVERSE PREGNANCY OUTCOMES. Vestnik SurGU. Meditsina. 2019;(4 (42)):66-73. (In Russ.) https://doi.org/10.34822/2304-9448-2019-4-66-73
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