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THE ROLE OF FETAL MICROCHIMERISM IN THE PATHOGENESIS OF SYSTEMIC DISEASES

Abstract

The aim of the study is to determine the role of microchimerism in the pathogenesis of systemic autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, systemic scleroderma) according to the analysis of evidence-based medicine data and literature review. Material and methods. The study of scientific Russian and foreign literature in such databases as Springer, Scopus, eLIBRARY.RU, Web of Science, MEDLINE, PubMed
Central, BioMed Central for the last 8 years is made. The following keywords were used in the literary search: microchimerism, graft-versus-host disease, systemic lupus erythematosus, rheumatoid arthritis, systemic scleroderma. The 35 current publications have been identified; information from 22 resources was included in the analysis; there are 6 prospective and 12 retrospective studies among them. Results. Fetal microchimerism is insufficiently studied. It is still unclear how fetal cells undergo differentiation within the mother and affect organs
and tissues in systemic diseases. The role of microchimeric cells in the pathogenesis of immunological reactions of systemic diseases proceeding in a “graft-versus-host” type and their manifestation has not been identified yet.

About the Authors

E. V. Bubovich
Surgut State University
Russian Federation
PhD (Medicine), Assistant Professor, Department of Pathophysiology and General Pathology, Medical Institute


A. Yu. Zimenko
Surgut State University
Russian Federation
Postgraduate, Department of Pathophysiology and General Pathology, Medical Institute


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Review

For citations:


Bubovich E.V., Zimenko A.Yu. THE ROLE OF FETAL MICROCHIMERISM IN THE PATHOGENESIS OF SYSTEMIC DISEASES. Vestnik SurGU. Meditsina. 2019;(3 (41)):70-75. (In Russ.)

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