THE ROLE OF FETAL MICROCHIMERISM IN THE PATHOGENESIS OF SYSTEMIC DISEASES
Abstract
Central, BioMed Central for the last 8 years is made. The following keywords were used in the literary search: microchimerism, graft-versus-host disease, systemic lupus erythematosus, rheumatoid arthritis, systemic scleroderma. The 35 current publications have been identified; information from 22 resources was included in the analysis; there are 6 prospective and 12 retrospective studies among them. Results. Fetal microchimerism is insufficiently studied. It is still unclear how fetal cells undergo differentiation within the mother and affect organs
and tissues in systemic diseases. The role of microchimeric cells in the pathogenesis of immunological reactions of systemic diseases proceeding in a “graft-versus-host” type and their manifestation has not been identified yet.
About the Authors
E. V. BubovichRussian Federation
PhD (Medicine), Assistant Professor, Department of Pathophysiology and General Pathology, Medical Institute
A. Yu. Zimenko
Russian Federation
Postgraduate, Department of Pathophysiology and General Pathology, Medical Institute
References
1. Rumyantsev A. G., Mareeva Y. M. Materinskii mikrokhimerizm i ego klinicheskoe znachenie // Pediatria. 2011. No. 4. P. 6–11. (In Russian).
2. Rumiantsev A. G., Kurtser M. A., Mareeva Iu. B., Misiurin A. V., Rumiantsev S. A., Ustiugov A.Iu. Klinicheskoe znachenie materinskogo mikrokhimerizma u detei //
3. Kletochnaia transplantologiia i tkanevaia inzheneriia. 2011. No. 2. P. 10–14. (In Russian).
4. Dierselhuis M. P., Jankowska-Gan E., Blokland E., Pool J., Burlingham W. J., van Halteren A. G. S., Goulmy E. HY Immune Tolerance is Common in Women without Male Offspring // PLOS ONE. 2014. P. 1–10. DOI: 10.1371/journal.pone.0091274.
5. Sabanova E. A., Platonova N. M., Mel’nichenko G. A. Microchimerism and Thyroid Disorders: Current Knowledge and Future Prospects // Clinical and
6. Experimental Thyroidology. 2014. No. 4. P. 34–40. (In Russian).
7. Chhabra A. Y., Chmait R. H., Cirello V., Crooks K. Chimerism. A Clinical Guide // Springer Nature, 2018.
8. Anzalone R., Atala A., Atkinson K., Baba K. A book Perinatal Stem Cells //Springer, 2014.
9. Cismaru A., Pop L., Berindan-Neagoe I. Incognito: Are Microchimeric Fetal Stem Cells that Cross-Placental Barrier Real Emissaries of Peace? // Stem Cell Reviews and Reports. 2018. P. 632–641. DOI:10.1007/s12015-018-9834-9.
10. Rijnink E., Penning M., Wolterbeek R., Wilhelmus S., Zandbergen M., van Duinen S. G., Schutte J., Bruijn J. A., Bajema I. M. Tissue Microchimerism is Increased During Pregnancy: a Human Autopsy Study // Molecular
11. Human Reproduction. 2015. Vol. 0, No. 0. P. 1–8.
12. Rumyantsev A. G., Kurcer M. A., Mareeva Ju. M., Misjurin A. V., Roumiantsev S. A., Ustjugov A. Ju. Clinical Significance of the Fetal Microchimerism for Mother // Kletochnaia transplantologiia i tkanevaia inzheneriia. 2012. Vol. VII, No. 2. P. 103–111. (In Russian).
13. Churilov L. P. Obshchaia patofiziologiia (s osnovami immunopatologii). SPb. : ELBI-SPb, 2015. 656 p. (In Russian).
14. Boddy A. M., Fortunato A., Wilson Sayres M., Aktipis A. Fetal Microchimerism and Maternal Health: A Review and Evolutionary Analysis of Cooperation
15. and Conflict Beyond the Womb // BioEssays. 2015. No. 37. P. 1106–1118.
16. Liptak N., Hoffmann O. I., Kerekes A., Iski G., Ernszt D., Kvell K., Hiripi L., Bosze Z. Monitoring of Venus Transgenic Cell Migration During Pregnancy in Non-
17. Transgenic Rabbits // Transgenic Res. 2017. P. 291–299. DOI 10.1007/s11248-016-9994-9.
18. Kekow M., Barleben M., Drynda S., Jakubiczka S., Kekow J., Brune T. Long-term Persistence and Effects of Fetal Microchimerisms on Disease Onset and Status in a Cohort of Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus // BMC Musculoskeletal Disorders. 2013. P. 1–8. DOI 10.1186/1471-2474-14-325.
19. Nasonov E. L., Nasonova V. A. Revmatologiia: natsionalnoe rukovodstvo. Moscow : GEOTAR-Media, 2010. 720 p. (In Russian).
20. Stroev Iu. I., Churilov L. P. Sistemnaia patologiia soedinitelnoi tkan i: rukovodstvo dlia vrachei. Saint-Petersburg : ELBI-SPb, 2014. 368 p. (In Russian).
21. Brumfield B. “Suicide Handshakes” Kill Precursor T Cells that Pose Autoimmune Dangers Posted // Georgia Institute of Technology. 2018. November 12.
22. Nelson J. L., Lambert N. C. Forward and Reverse Inheritance – the Yin and the Yang // Nature Reviews Rheumatology. 2017. No. 13 (7). P. 396–397.
23. Stahlberg A., El-Heliebi A., Sedlmayr P., Kroneis T. Unravelling the biological secrets of microchimerism by single-cell analysis // Briefings in Functional
24. Genomics. 2018. No. 17 (4). P. 255–264.
25. Chakravarty E. Pre-disease Pregnancy Complications and Systemic Sclerosis: Pathogenic or Pre-clinical? // Arthritis Research & Therapy. 2012.No. 14 (1).
26. P. 102.
27. Badokin V. V. Revmatologiia. Klinicheskie lektsii. LitTerra, 2014. 592 p. (In Russian).
28. Guseva N. G., Guseva H. G. Systemic Scleroderma is a Multidisciplinary Problem // Rheumatology Science and Practice. 2011. No. 2. P. 10–14. (In Russian).
29. Di Cristofaro J., Karlmark K. R., Kanaan S. B., Azzouz D. F. Soluble HLA-G Expression Inversely Correlates With Fetal Microchimerism Levels in Peripheral Blood From Women With Scleroderma // Frontiers in Immunology.
30. No. 8. P. 1–11.
Review
For citations:
Bubovich E.V., Zimenko A.Yu. THE ROLE OF FETAL MICROCHIMERISM IN THE PATHOGENESIS OF SYSTEMIC DISEASES. Vestnik SurGU. Meditsina. 2019;(3 (41)):70-75. (In Russ.)