EFFECT OF MODIFIED CARBONACEOUS SORBENTS ON THE ACTIVITY OF ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE PANCREATITIS
Abstract
The aim of the study is to determine the activity of antioxidant enzymes of blood before and after contact with granulated modified carbonaceous sorbents to assess their possible effectiveness in the complex treatment of patients with acute pancreatitis. Material and methods. Sorption methods of treatment with the use of granulated carbonaceous molded sorbent are carried out in 10 men with acute pancreatitis who were admitted to the hospital of Omsk in an emergency. Results. It is established that the granulated carbonaceous sorbents treated with various modifiers enhance the activity of the main antioxidant enzymes of the first and second protective lines, the antioxidant system in patients with acute oedematous pancreatitis. The results of these studies allow stating that investigated sorbents are of considerable interest for sorption treatments and can be recommended for the prevention and correction of oxidative stress that occurs in inflammatory processes.
About the Authors
V. T. Dolgikh
V. A. Negovsky Research Institute of General Reanimatology, Institute of Professional Development and Enrichment, Moscow
Russian Federation
Doctor of Science (Medicine), Professor, Honoured Science Worker of the Russian Federation, Leading Researcher, Head, Department of Pathophysiology
Russian Federation
Doctor of Science (Medicine), Professor, Honoured Science Worker of the Russian Federation, Leading Researcher, Head, Department of Pathophysiology
L. G. Pyanova
Institute of Hydrocarbon Processing, Siberian Branch of the Russian Academy of Sciences, Omsk.
Russian Federation
Doctor of Science (Biology), Associate Professor, Senior Researcher
Russian Federation
Doctor of Science (Biology), Associate Professor, Senior Researcher
E. S. Efremenko
Omsk State Medical University
Russian Federation
PhD (Medicine), Head, Department of Biochemistry
Russian Federation
PhD (Medicine), Head, Department of Biochemistry
Yu. P. Orlov
Omsk State Medical University
Russian Federation
Doctor of Science (Medicine), Professor, Department of Anesthesiology and Emergency Medicine
Russian Federation
Doctor of Science (Medicine), Professor, Department of Anesthesiology and Emergency Medicine
A. N. Zolotov
Omsk State Medical University (Omsk)
Russian Federation
PhD (Medicine), Department of Pathophysiology, Clinical Pathophysiology
Russian Federation
PhD (Medicine), Department of Pathophysiology, Clinical Pathophysiology
V. A. Likholobov
Institute of Hydrocarbon Processing, Siberian Branch of the Russian Academy of Sciences, Omsk
Russian Federation
Doctor of Science (Chemistry), Professor, Corresponding Member of Russian Academy of Sciences,
Academic Supervisor
Russian Federation
Doctor of Science (Chemistry), Professor, Corresponding Member of Russian Academy of Sciences,
Academic Supervisor
A. V. Ershov
V. A. Negovsky Research Institute of General Reanimatology, Institute of Professional Development and Enrichment, Moscow
Russian Federation
Doctor of Science (Medicine), Associate Professor, Senior Researcher, Associate Professor, Department of Pathophysiology
Russian Federation
Doctor of Science (Medicine), Associate Professor, Senior Researcher, Associate Professor, Department of Pathophysiology
I. V. Utrobina
V. A. Negovsky Research Institute of General Reanimatology, Moscow
Russian Federation
Junior Researcher
Russian Federation
Junior Researcher
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Review
For citations:
Dolgikh V.T., Pyanova L.G., Efremenko E.S., Orlov Yu.P., Zolotov A.N., Likholobov V.A., Ershov A.V., Utrobina I.V. EFFECT OF MODIFIED CARBONACEOUS SORBENTS ON THE ACTIVITY OF ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE PANCREATITIS. Vestnik SurGU. Meditsina. 2019;(2 (40)):95-99. (In Russ.)
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