SERUM LEVELS OF BIOMARKER OF HEMODYNAMIC STRESS AND MORPHOFUNCTIONAL CHANGESOF LEFT VENTRICLE IN PATIENTS WHO ENDURED ST-ELEVATED MYOCARDIAL INFARCTION
Abstract
The goal of the article is to establish the relationship between indicators of the structure and function of the left ventricle in patients who have endured a myocardial infarction with ST-segment elevation. We examined the left ventricle during its post-infarction remodeling for 12 months with serum levels of NT-proBNP (N-Terminal proBrain Natriuretic Peptide), identified in the acute phase of myocardial infarction. In 108 patients with acute ST- elevated myocardial infarction, the biomarker is an amino-terminal fragment of the precursor of brain natriuretic peptide precursor. In patients with postinfarction left ventricular remodeling, the values of the NT-proBNP are higher (p = 0.03), which correlate with the degrees of systolic and diastolic dysfunction of the left ventricle (p <0.05). The evaluation of this biomarker in the acute phase of myocardial infarction may be of clinical importance for the selection of patients at high risk of developing heart failure.
About the Authors
A. S. Vorobyov
Surgut State University
Russian Federation
Russian Federation
L. V. Kovalenko
Surgut State University
Russian Federation
Russian Federation
I. D. Astrakhantseva
Surgut District Cardiologic Dispensary
Russian Federation
Russian Federation
I. A. Urvantseva
Surgut State University; Surgut District Cardiologic Dispensary
Russian Federation
Russian Federation
References
1. Opie L. H., Commerford P. J. et al. Controversies in ventricular remodeling // Controvers Cardiol. 2006. Vol. 367. P. 33-44.
2. Galli A., Lombardi F. Postinfarct left ventricular remodeling: a prevailing cause of heart failure // Cardiology research and practice. 2016. Vol. 1. P. 1-12.
3. Jarolim P. Overview of cardiac markers in heart disease // Clin Lab Med. 2014. Vol. 34 (1). P. 1-14.
4. Жебель В. М., Пашкова Ю. П., Сакович О. О. и соавт. Клинические и клинико-генетические аспекты определения натрийуретического пептида у пациентов с хронической сердечной недостаточностью: достижения и перспективы // Серцева недостатність. 2016. № 1. С. 14-18.
5. Печерина Т. Б., Федорова Н. В., Герман А. И. и соавт. Клиническая значимость и динамика биомаркеров ремоделирования миокарда у больных инфарктом миокарда с подъемом сегмента ST и сохраненной функцией левого желудочка // Атеросклероз. 2018. Т. 14. № 1. С. 5-14.
6. Федотова И. Н., Белопольский А. А., Стуров Н. В. Диагностическая значимость NT-proBNP у кардиологических больных // Трудный пациент. 2013. № 7. С. 32-25.
7. Ibanez B., James S. et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) // Eur Heart J. 2018. Vol. 7. № 39 (2). P. 119-177.
8. Hendriks T., Minke H., Hartman J. Predictors of left ventricular remodeling after ST-elevation myocardial infarction // Int J Cardiovasc Imaging. 2017. Vol. 33. P. 1415-1423.
9. Ezekowitz J., Armstrong P., Granger C. et al. Predicting chronic left ventricular dysfunction 90 days after ST-segment elevation myocardial infarction: an assessment of pexelizumab in acute myocardial infarction (APEX-AMI) substudy // Am Heart J. 2010. Vol. 160. № 2. P. 272-278.
10. Paelinck B., Vrints C., Bax J. et al. Relation of B-type natriuretic peptide early after acute myocardial infarction to left ventricular diastolic function and extent of myocardial damage determined by magnetic resonance imaging // Am J Cardiol. 2006. Vol. 97. P. 1146-1150.
11. Garcia-Alvarez A., Sitges M., Delgado V. et al. Relation of plasma brain natriuretic peptide levels on admission for ST-elevation myocardial infarction to left ventricular end-diastolic volume six months later measured by both echocardiography and cardiac magnetic resonance // Am J Cardiol. 2009. Vol. 104. P. 878-882.
12. Flachskampf F. A., Schmid M., Rost C. et al. Cardiac imaging after myocardial infarction // Eur Heart J. 2011. Vol. 32. № 3. P. 272-283.
13. Hirayama A., Kusuoka H., Yamamoto H. et al. Usefulness of plasma brain natriuretic peptide concentration for predicting subsequent left ventricular remodeling after coronary angioplasty in patients with acute myocardial infarction // Am J Cardiol. 2006 Vol. 98. P. 453-457.
14. Cochet A., Zeller M., Cottin Y. et al. The extent of myocardial damage assessed by contrast-enhanced MRI is a major determinant of N-BNP concentration after myocardial infarction // Eur J Heart Fail. 2004. Vol. 6. P. 555-560.
15. Joost D., Niels J., Wichert J. et al. Comparison of Usefulness of N-Terminal Pro-Brain Natriuretic Peptide as an Independent Predictor of Cardiac Func tion Among Admission Cardiac Serum Biomarkers in Patients With Anterior Wall Versus Nonanterior Wall ST-Segment Elevation Myocardial Infarction Undergoing Primar y Percutaneous Coronary Intervention // Am J Cardiol. 2010. Vol. 105 (8). P. 1065-1069.
16. Ang D., Kong C., Kao M. et al. Serial bedside B-type natriuretic peptide strongly predicts prognosis in acute coronar y syndrome independent of echocardiographic abnormalities // Am Heart J. 2009. Vol. 158 (1). P. 133-40.
17. Vogiatzis I., Dapcevic I., Datsios A. et al. A Comparison of Prognostic Value of the Levels of ProBNP and Troponin T in Patients with Acute Coronary Syndrome (ACS) // Med Arch. 2016. Vol. 70 (4). P. 269-273.
18. Лузин В. Г., Урванцева И. А., Ковальчук Д. Н. и соавт. Анализ влияния прогноз-негативных факторов на госпитальную смертность у пациентов с острым инфарктом миокарда, перенесших ургентное коронарное шунтирование // Вестник СурГУ. Медицина. 2017. № 2. С. 36-38.
Review
For citations:
Vorobyov A.S., Kovalenko L.V., Astrakhantseva I.D., Urvantseva I.A. SERUM LEVELS OF BIOMARKER OF HEMODYNAMIC STRESS AND MORPHOFUNCTIONAL CHANGESOF LEFT VENTRICLE IN PATIENTS WHO ENDURED ST-ELEVATED MYOCARDIAL INFARCTION. Vestnik SurGU. Meditsina. 2018;(4 (38)):13-19. (In Russ.)
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