DEFEROXAMIN REDUCES INTENSITYOF FREE-RADICAL OXIDATION PROCESSES IN MECHANICAL INJURY
Abstract
He purpose of the scientific study is to reveal mechanisms of the damaging effect of ionized iron in severe mechanical injury and to estimate efficiency of deferoxamine use to reduce the intensity of free-radical oxidation processes in the post-traumatic period. The experiments were carried out on 40 white Wistar male rats. The animals were injured in the middle third of the thigh on both sides with a preliminary injection of deferoxamine at a dose of 80 mg/kg in 5 ml of a 0.9 % NaCl solution into the abdominal cavity. In the blood serum contents of serum iron, transferrin and ferritin, spontaneous luminosity, rapid flare, light sum and latent stage of blood viscosity, low and medium molecular weight substances and oligopeptides were determined. It has been established that the use of deferoxamine in severe mechanical injuries accompanied by massive hemolysis of erythrocytes is promising and pathogenetically substantiated.
About the Authors
V. T. Dolgikh
Omsk State Medical University
Russian Federation
Russian Federation
A. V. Ivanov
Omsk State Medical University
Russian Federation
Russian Federation
Y. P. Orlov
Omsk State Medical University
Russian Federation
Russian Federation
N. V. Govorova
Omsk State Medical University
Russian Federation
Russian Federation
O. V. Korpacheva
Omsk State Medical University
Russian Federation
Russian Federation
S. V. Palyanov
Omsk State Medical University
Russian Federation
Russian Federation
References
1. Багненко С. Ф., Минуллин И. П., Чикин А. Е. и др. Совершенствование медицинской помощи пострадавшим при дорожнотранспортных происшествиях // Вестн. Росздравнадзора. 2013. № 5. С. 25-30.
2. Wang A. M., Yin X., Sun H. Z. et al. Damage control orthopedics in 53 cases of severe polytrauma who have mainly sustained orthopaedic trauma // Clin J Traumatol. 2008. Vol. 11. № 5. P. 283-287.
3. Межидов С. Х., Тома А. И. Метаболизм железа при травматической болезни // Вестн. травматологии и ортопедии им. Н. Н. Приорова. 2007. № 2. С. 88-91.
4. Оберлис Д., Харланд Б., Скальный А. Билогическая роль макро- и микроэлементов у человека и животных. СПб. : Наука, 2008. 544 с.
5. Иванов С. Д. Железо как канцерогенный экотоксикант // Токсиколог. вестн. 2011. № 2. С. 34-40.
6. Владимиров Ю. А., Проскурина Е. В., Измайлов Д. Ю. и др. Кардиолипин активирует пероксидазную активность цитохромас, потому что увеличивает доступность железа гемма для Н2О2 // Биохимия. 2006. Т. 71. № 3. С. 1225-1232.
7. Finazzi D., Arosio P. Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration // Arch. Toxicol. 2014. Vol. 88. № 10. P. 1787-1802.
8. Cha Y. J., Chang E. A., Kim C. H. Effects of endothelial cells and mononuclear leukocytes on platelet aggregation // Haematologia (Budap). 2000. Vol. 30. № 2. C. 97-106.
9. Irwin D. C., Baek J. H., Hassell К., Nuss R., Eigenberger Р., Lisk С., Loomis Z. et al. Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration // Free Radic Biol Med. 2015 May. P. 50-62.
10. Орлов Ю. П., Ершов А. В. Ингибирование процессов липопероксидации с помощью десферала при экспериментальном панкреонекрозе // Общая реаниматология. 2007. № 4. С. 106-109.
11. Орлов Ю. П., Иванов А. В., Долгих В. Т. и др. Нарушение обмена железа в патогенезе критических состояний // Общая реаниматология. 2011. № 5. С. 17-21.
12. Gutterige J. M. C., Halliwell В. Free radical and antioxidants in the year 2000 // A historical look to the future. Ann. N.Y. Acad. Sci. 2000. 899. P. 136-147.
13. Balaban R. S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell. 2005. 120. P. 483-495.
14. Weinberg E. D. Iron toxicity. New conditions continue to emerge // Oxid Med Cell Longev. 2009, Apr-Jun. № (2). P. 107-109.
15. Руководство ВОЗ. URL: www.cioms.ch/publication/ guidelines (дата обращения: 25.12.2017).
Review
For citations:
Dolgikh V.T., Ivanov A.V., Orlov Y.P., Govorova N.V., Korpacheva O.V., Palyanov S.V. DEFEROXAMIN REDUCES INTENSITYOF FREE-RADICAL OXIDATION PROCESSES IN MECHANICAL INJURY. Vestnik SurGU. Meditsina. 2018;(1 (35)):85-89. (In Russ.)
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