LOCAL ENDOMETRIAL INJURY BEFORE THAWED EMBRYOS TRANSFER IN PATIENTS WITH ENDOMETRIAL HYPOPLASIA
https://doi.org/10.35266/2304-9448-2023-3-42-46
Abstract
The study aims to examine the influence of local endometrial injury on the results of thawed embryo transfer programs in patients with endometrial hypoplasia based on the analysis of clinical cases. The author analyzes two clinical cases of performing scratching prior to the implementation of the assisted reproductive technologies program in patients with “thin” endometrium and evaluates its effectiveness. Embryo implantation is a key stage limiting the effectiveness of assisted reproductive technologies, and depends on the receptivity and selectivity of theendometrium, the quality of the blastocyst, as well as on their cross-interaction. At the same time, two-thirds of implantation failures may be associated with endometrium impaired susceptibility. Endometrial hypoplasia is believed to be associated with a decrease in the probability of embryo attachment. Various therapeutic approaches have been proposed to improve its receptivity. The technology of local damage to the uterine mucosa was applied before the program of assisted reproductive technologies in two patients with “thin” endometrium. Following the transfer of thawed embryos, uterine pregnancy occurred in both cases, which ended with operative delivery on time.
About the Author
S. I. Semenchenko
Khanty-Mansiysk State Medical Academy,
District Clinical Hospital, Khanty-Mansiysk
Russian Federation
Russian Federation
Candidate of Sciences (Medicine), Docent, Obstetrician-Gynecologist
E-mail: serg.sem76@gmail.com
References
1. Vitagliano A., Andrisani A., Alviggi C. et al. Endometrial scratching for infertile women undergoing a first embryo transfer: A systematic review and meta-analysis of published and unpublished data from randomized controlled trials. Fertil Steril. 2019;111(4):734–746.e2.
2. Nastri C. O., Lensen S. F., Gibreel A. et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2015;(3):CD009517.
3. Van Hoogenhuijze N. E., Mol F., Laven J. S. E. et al. Endometrial scratching in women with one failed IVF/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH). Hum Reprod. 2021;36(1):87–98.
4. Simon C., Giudice L. C. The endometrial factor: A reproductive precision medicine approach. Boca Raton, FL: CRC Press; 2017. 284 p.
5. Craciunas L., Gallos I., Chu J. et al. Conventional and modern markers of endometrial receptivity: A systematic review and meta-analysis. Hum Reprod Update. 2019;25(2):202–223.
6. Macklon N. S., Brosens J. J. The human endometrium as a sensor of embryo quality. Biol Reprod. 2014;91(4):98.
7. Miravet-Valenciano J. A., Rincon-Bertolin A., Vilella F. et al. Understanding and improving endometrial receptivity. Curr Opin Obstet Gynecol. 2015;27(3):187–192.
8. Simón C., Gómez C., Cabanillas S. et al. A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF. Reprod Biomed Online. 2020;41(3):402–415.
9. Liu K. E., Hartman M., Hartman A. Management of thin endometrium in assisted reproduction: a clinical practice guideline from the Canadian Fertility and Andrology Society. Reprod Biomed Online. 2019;39(1):49-62.
10. Aydin T., Kara M., Nurettin T. Relationship between endometrial thickness and in vitro fertilization-intracytoplasmic sperm injection outcome. Int J Fertil Steril. 2013;7(1):29–34.
11. Kasius A., Smit J. G., Torrance H. L. et al. Endometrial thickness and pregnancy rates after IVF: A systematic review and meta-analysis. Hum Reprod Update. 2014;20(4):530–541.
12. Ribeiro V. C., Santos-Ribeiro S., De Munck N. et al. Should we continue to measure endometrial thickness in modern-day medicine? The effect on live birth rates and birth weight. Reprod Biomed Online. 2018;36(4):416–426.
13. Ovarian Stimulation TEGGO, Bosch E., Broer S. et al. ESHRE guideline: Ovarian stimulation for IVF/ICSI†. Hum Reprod Open. 2020;2020(2):hoaa009.
14. Casper R. F. It’s time to pay attention to the endometrium. Fertil Steril. 2011;96(3):519–521.
15. Rombauts L., McMaster R., Motteram C. et al. Risk of ectopic pregnancy is linked to endometrial thickness in a retrospective cohort study of 8120 assisted reproduction technology cycles. Hum Reprod. 2015;30(12):2846–2852.
16. Liu H., Zhang J., Wang B. et al. Effect of endometrial thickness on ectopic pregnancy in frozen embryo transfer cycles: An analysis including 17,244 pregnancy cycles. Fertil Steril. 2020;113(1):131–139.
17. Gonen Y., Casper R. F., Jacobson W. et al. Endometrial thickness and growth during ovarian stimulation: A possible predictor of implantation in in vitro fertilization. Fertil Steril. 1989;52(3):446–450.
18. Liu K. E., Hartman M., Hartman A. et al. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: An analysis of over 40 000 embryo transfers. Hum Reprod. 2018;33(10):1883–1888.
19. Barash A., Dekel N., Fieldust S. et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003;79(6):1317–1322.
20. Potdar N., Gelbaya T., Nardo L. G. Endometrial injury to overcome recurrent embryo implantation failure: A systematic review and meta-analysis. Reprod Biomed Online. 2012;25(6):561–571.
21. Nastri C. O., Ferriani R. A., Raine-Fenning N. et al. Endometrial scratching performed in the non-transfer cycle and outcome of assisted reproduction: A randomized controlled trial. Ultrasound Obstet Gynecol. 2013;42(4):375–382.
22. Mackens S., Racca A., van de Velde H. et al. Follicular-phase endometrial scratching: A truncated randomized controlled trial. Hum Reprod. 2020;35(5):1090–1098.
23. Краснопольская К. В., Назаренко Т. А., Федоров А. А. и др. Влияние на эффективность ЭКО эндометриального скретчинга, назначаемого пациенткам с ультразвуковыми признаками экстремально «тонкого» эндометрия // Медицинский алфавит. 2016. Т. 3, № 27. С. 39–43.
24. Краснопольская К. В., Назаренко Т. А., Левиашвили М. М. и др. Клинические исходы стандартных программ ЭКО у пациенток с ультразвуковыми признаками «тонкого» эндометрия и влияние на его рецептивность интенсивной поддержки эстрогенами // Проблемы репродукции. 2016. Т. 22, № 3. С. 57–62. DOI 10.17116/repro201622357-62.
25. Краснопольская К. В., Федоров А. А., Ершова И. Ю. и др. Клинические исходы программ ЭКО с ооцитами донора при использовании технологии эндометриального скретчинга у пациенток с умеренным и экстремальным отставанием развития эндометрия // Медицинский алфавит. 2017. Т. 1, № 3. С. 46–50.
Review
For citations:
Semenchenko S.I. LOCAL ENDOMETRIAL INJURY BEFORE THAWED EMBRYOS TRANSFER IN PATIENTS WITH ENDOMETRIAL HYPOPLASIA. Vestnik SurGU. Meditsina. 2023;16(3):42-46. https://doi.org/10.35266/2304-9448-2023-3-42-46
Views:
120
Email this article 
