OPTIMIZATION OF TREATMENT FOR HPV-INDUCED SKIN PROLIFERATION

Abstract

The study aims to evaluate the effectiveness of the developed method for treating skin proliferation induced by human papillomavirus using the cytokine-like peptide (alloferon) and radio wave excision. Material and methods. The study included 109 patients. Among them were 46 people with plantar warts, 16 people with genital warts, and 47 people with papillomas and keratosis (senile and seborrheic). The patients were divided into two groups. The main group was represented by 65 patients who had the removal of proliferation with the administration of alloferon. The 44 patients in the comparison group had only the removal of the skin proliferation induced by the human papillomavirus. Results. During 12 months of observation relapses of plantar warts were noted in 26.3 % of patients in the comparison group and only in 3.7 % of patients in the main group. Relapses of genital warts were observed in two patients (28.6 %) in the comparison group and none of the nine patients in the main group. Spontaneous regression or a significant decrease in the size of more than a third of the papillomas and keratosis was observed in 65.5 % of patients in the main group after the 3rd course of allokin-alpha. None of the 18 patients in the comparison group had a similar effect.