surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.35266/2949-3447-2024-4-9surgumed-800Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ. ОБЗОР ЛИТЕРАТУРЫLIFE SCIENCES. REVIEWSВНЕКЛЕТОЧНЫЕ ЛОВУШКИ – НОВАЯ ФУНКЦИЯ НЕЙТРОФИЛОВ И ИХ РОЛЬ В ВОСПАЛЕНИИ И ГЕМОСТАЗЕEXTRACELLULAR TRAPS: A NEW FUNCTION OF NEUTROPHILS AND THEIR ROLE IN INFLAMMATION AND HEMOSTASIShttps://orcid.org/0000-0003-2781-1180КисинаТ. Е.KisinaT. E.

доцент

Docent

myiya@mail.ruhttps://orcid.org/0000-0001-6613-2485ВоробьеваН. А.VorobyevaN. A.

заведующая кафедрой

Head of the Department

Северный государственный медицинский университет Минздрава России, АрхангельскРоссияNorth State Medical University, ArkhangelskRussian Federation20242012202417463–74Copyright © Кисина Т.Е., Воробьева Н.А., 20242024Кисина Т.Е., Воробьева Н.А.Kisina T.E., Vorobyeva N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/800

Цель – провести обзор научной литературы в базах данных PubMed и КиберЛенинка с глубиной поиска 10 лет по ключевым словам: нетоз, нейтрофильные ловушки, нейтрофильные гранулоциты, тромбоциты, инфламасома, коронавирусная инфекция, посвященный анализу фагоцитарной активности нейтрофилов, механизмов образования внеклеточных ловушек, их функции и роли в воспалении, связи с патогенезом гемостаза, роли нейтрофильных ловушек в физиологии, патогенезе заболеваний, инфекционном процессе при COVID-19. В свете последних научных данных и во многом вследствие пандемии COVID-19 произошел пересмотр связи воспаления и иммунного ответа с гемостазом и тромбобразованием, ключевыми клетками этой связи оказались нейтрофилы и их внеклеточные ловушки.

The aim of the article is to review the scientific literature in PubMed and CyberLeninka databases with a search depth of 10 years using the following keywords: neutrophil extracellular traps, neutrophil granulocytes, platelets, inflammasome, coronavirus infection. Phagocytic activity of neutrophils, mechanisms of extracellular trap formation, their functions and roles in inflammation, connections with pathogenesis of hemostasis, roles of neutrophil traps in physiology, pathogenesis of diseases, infectious process in COVID-19 are discussed. The COVID-19 pandemic, along with new scientific evidence, has prompted a reevaluation of the link between inflammation and immune response, hemostasis and thrombosis. This reevaluation has highlighted neutrophils and their extracellular traps as crucial cells in this connection.

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The authors declare that there are no conflicts of interest present.