surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.35266/2304-9448-2023-3-15-23surgumed-675Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНА. ОБЗОР ЛИТЕРАТУРЫCLINICAL MEDICINE. REVIEWSСОВРЕМЕННЫЕ ВОЗМОЖНОСТИ ПРОГНОЗИРОВАНИЯ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙMODERN POSSIBILITIES OF BRONCHIAL ASTHMA PREDICTION IN CHILDRENhttps://orcid.org/0000-0002-5729-8405ГапоненкоВ. П.GaponenkoV. P.

ассистент, аспирантE-mail: v.p.gaponenko@yandex.ru

Assistant Professor, PostgraduateE-mail: v.p.gaponenko@yandex.ru

ШлыковаЕ. Э.ShlykovaE. E.

заместитель главного врача по медицинской части

E-mail: 55@gdkb2-omsk.ru

Deputy Chief Medical Officer in Medical Field

E-mail: 55@gdkb2-omsk.ru

Омский государственный медицинский университет Минздрава России, ОмскРоссияOmsk State Medical University, OmskRussian FederationГородская детская клиническая больница № 2 имени В. П. Бисяриной, ОмскРоссияCity Clinical Hospital for Children No. 2 named after V. P. Bisyarina, OmskRussian Federation2023270920231631523Copyright © Гапоненко В.П., Шлыкова Е.Э., 20232023Гапоненко В.П., Шлыкова Е.Э.Gaponenko V.P., Shlykova E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/675

Цель – обобщение сведений из источников российской и зарубежной литературы в базах данных PubMed, eLIBRARY.RU с глубиной поиска 25 лет о методах стратификации риска бронхиальной астмы у детей, преимущественно с бронхообструктивным синдромом. Представлено сравнение различных предиктивных моделей, таких как традиционные клинико-лабораторные шкалы и высокотехнологичные мономаркеры заболевания с акцентом на проспективные исследования, представляющие наибольшую ценность. Рассмотрен теоретический потенциал и практические результаты изучения белков внеклеточного матрикса периостина и ламинина в качестве прогностических маркеров бронхиальной астмы у детей.

The study aims to generalize data on the topic of methods for risk stratification of bronchial asthma in children, preliminary with wheezing, obtained from domestic and foreign literature from PubMed and eLIBRARY.RU. The search depth was 25 years. The study compared numerous predictive models, such as traditional clinical and laboratory scoring systems and high-technology monomarkers of a disease, with an emphasis on the most informative prospective examinations. The theoretical potential and practical results of studying protein in the extracellular matrix of periostin and laminin were analyzed as forecast markers of bronchial asthma in children.

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The authors declare that there are no conflicts of interest present.