surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.35266/2304-9448-2023-1-35-41surgumed-628Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНА. ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕCLINICAL MEDICINE. ORIGINAL RESEARCHДВИГАТЕЛЬНАЯ АКТИВНОСТЬ ПЛОДА И МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ТКАНИ ПЛАЦЕНТЫ У ПАЦИЕНТОК С РАННЕЙ И ПОЗДНЕЙ ПРЕЭКЛАМПСИЕЙFETAL MOTOR ACTIVITY AND MORPHOLOGICAL FEATURES OF PLACENTAL TISSUE IN PATIENTS WITH EARLY AND LATE PREECLAMPSIAhttps://orcid.org/0000-0001-6995-4863БелоцерковцеваЛ. Д.BelotserkovtsevaL. D.

доктор медицинских наук, профессор, президентinfo@surgut-kpc.ru

Doctor of Sciences (Medicine), Professor, Presidentinfo@surgut-kpc.ru

https://orcid.org/0000-0002-5617-9906ВасечкоТ. М.VasechkoT. M.

кандидат медицинских наук, доцентdocvivatm@gmail.com

Candidate of Sciences (Medicine), Associate Professordocvivatm@gmail.com

https://orcid.org/0000-0003-4415-7897МордовинаИ. И.MordovinaI. I.

кандидат медицинских наук, доцентmar-mariot@yandex.ru

Candidate of Sciences (Medicine), Associate Professormar-mariot@yandex.ru

https://orcid.org/0000-0003-2138-0682МурзаеваА. З.МurzaevaA. Z.

преподаватель

aigul3161@yandex.ru

Lectureraigul3161@yandex.ru

https://orcid.org/0000-0001-6079-8841СинюковаТ. А.SinyukovaT. A.

научный сотрудник

proles@bk.ru

Researcher

proles@bk.ru

Сургутский государственный университет, Сургут; Сургутский окружной клинический центр охраны материнства и детства, СургутРоссияSurgut State University, Surgut; Surgut District Clinical Center of Maternity and Childhood Health Care, SurgutRussian FederationСургутский государственный университет, СургутРоссияSurgut State University, SurgutRussian Federation2023060420231613541Copyright © Белоцерковцева Л.Д., Васечко Т.М., Мордовина И.И., Мурзаева А.З., Синюкова Т.А., 20232023Белоцерковцева Л.Д., Васечко Т.М., Мордовина И.И., Мурзаева А.З., Синюкова Т.А.Belotserkovtseva L.D., Vasechko T.M., Mordovina I.I., Мurzaeva A.Z., Sinyukova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/628

Цель – изучить особенности двигательной активности плода и типичные патоморфологические различия последов у женщин с ранней и поздней преэклампсией, проживающих в районах, приравненных к условиям Крайнего Севера (ХМАО-Югра). Проведен анализ 385 историй родов пациенток по группам (131 пациентки с ранним началом преэклампсии (до 34 недель), 144 пациенток – с поздним началом преэклампсии (после 34 недель) и 110 условно здоровых пациенток с физиологическим течением беременности), и анализ двигательной активности плода и морфологических исследований последов. У пациенток с ранней преэклампсией статистически значимо чаще выявлялось снижение двигательной активности плода при применении субъективных и объективных методов подсчета движений и чаще наблюдали нарушение созревания ворсин хориона, хорангиоз, инфаркты и псевдоинфаркты плаценты. При раннем и позднем начале преэклампсии преобладаловосходящее инфицирование плаценты.

The study aims to analyze the features of fetal motor activity and afterbirths’ common pathomorphological differences in women with early and late preeclampsia living in areas equated to the conditions of the Far North (Khanty-Mansi Autonomous Okrug – Ugra). The study examined 385 labor cases of patients who were classified as follows: 131 patients with early onset of preeclampsia (up to 34 weeks), 144 patients with late onset of preeclampsia (after 34 weeks), and 110 apparently healthy patients with the physiological course of pregnancy. The analysis of fetal motor activity and morphological studies of the afterbirths was carried out. When applyingsubjective and objective fetal movements counting methods, patients with early preeclampsia had statistically significantly lower fetal motor activity and more cases of chorionic villous maturation disorder, chorangiosis, myocardialinfarctions, and placental pseudoinfarctions. Ascending infection of the placenta prevails in both early and late-onset preeclampsia.

движения плодаплацентапреэклампсияплодбеременностьгипертензивные расстройстваморфологияfetal movementsplacentapreeclamspiafetuspregnancyhypertensive disordersmorphologyReferencesBrown M. A., Magee L. A., Kenny L. C. et al. Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension. 2018. Vol. 72, No. 1. P. 24–43.Brown M. A., Magee L. A., Kenny L. C. et al. Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension. 2018. Vol. 72, No. 1. P. 24–43.Kuklina E. V., Ayala C., Callaghan W. M. Hypertensive Disorders and Severe Obstetric Morbidity in the United States. Obstet Gynecol. 2009. Vol. 113, No. 6. P. 1299–1306.Kuklina E. V., Ayala C., Callaghan W. M. Hypertensive Disorders and Severe Obstetric Morbidity in the United States. Obstet Gynecol. 2009. Vol. 113, No. 6. P. 1299–1306.Phipps E. A., Thadhani R., Benzing T., Karumanchi S. A. Pre-eclampsia: Pathogenesis, Novel Diagnostics and Therapies. Nat Rev Nephrol. 2019. Vol. 15, No. 5. P. 275–289.Phipps E. A., Thadhani R., Benzing T., Karumanchi S. A. Pre-eclampsia: Pathogenesis, Novel Diagnostics and Therapies. Nat Rev Nephrol. 2019. Vol. 15, No. 5. P. 275–289.Hecht J. L., Zsengeller Z. K., Spiel M., Karumanchi S. A., Rosen S. Revisiting Decidual Vasculopathy. Placenta. 2016. Vol. 42. P. 37–43.Hecht J. L., Zsengeller Z. K., Spiel M., Karumanchi S. A., Rosen S. Revisiting Decidual Vasculopathy. Placenta. 2016. Vol. 42. P. 37–43.Ridder A., Giorgione V., Khalil A., Thilaganathan B. Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function. Int J Mol Sci. 2019. Vol. 20, No. 13. P. 3263.Ridder A., Giorgione V., Khalil A., Thilaganathan B. Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function. Int J Mol Sci. 2019. Vol. 20, No. 13. P. 3263.Levy M., Kovo M., Barda G. et al. Reduced Fetal Movements at Term, Low-Risk Pregnancies: Is It Associated with Adverse Pregnancy Outcomes? Ten Years of Experience from a Single Tertiary Center. Arch Gynecol Obstet. 2020. Vol. 301. P. 987–993.Levy M., Kovo M., Barda G. et al. Reduced Fetal Movements at Term, Low-Risk Pregnancies: Is It Associated with Adverse Pregnancy Outcomes? Ten Years of Experience from a Single Tertiary Center. Arch Gynecol Obstet. 2020. Vol. 301. P. 987–993.Bradford B. F., Cronin R. S., McKinlay C. J. D. et al. A Diurnal Fetal Movement Pattern: Findings from a Cross-Sectional Study of Maternally Perceived Fetal Movements in the Third Trimester of Pregnancy. PLoS One. 2019. Vol. 14, No. 6. P. e0217583.Bradford B. F., Cronin R. S., McKinlay C. J. D. et al. A Diurnal Fetal Movement Pattern: Findings from a Cross-Sectional Study of Maternally Perceived Fetal Movements in the Third Trimester of Pregnancy. PLoS One. 2019. Vol. 14, No. 6. P. e0217583.Gansburgsky A. N., Yaltsev A. V. Structural Features of the Monohorial Placent of Single-Finger Fruits. Blood Heart Circ. 2018. Vol. 2, No. 2. P. 1–3. DOI 1015761/BHC1000135.Gansburgsky A. N., Yaltsev A. V. Structural Features of the Monohorial Placent of Single-Finger Fruits. Blood Heart Circ. 2018. Vol. 2, No. 2. P. 1–3. DOI 1015761/BHC1000135.Gansburgskiy A., Yaltsev A. V. Arteries of the Chorion of Pregnant Women with Arterial Hypertension. Nurs Palliat Care. 2018. Vol. 3, No. 1. P. 1–4. DOI 10.15761/NPC.1000177.Gansburgskiy A., Yaltsev A. V. Arteries of the Chorion of Pregnant Women with Arterial Hypertension. Nurs Palliat Care. 2018. Vol. 3, No. 1. P. 1–4. DOI 10.15761/NPC.1000177.Staff A. C., Johnsen G. M., Dechend R., Redman C. W. G. Preeclampsia and Uteroplacental Acute Atherosis: Immune and Inflammatory Factors. J Reprod Immunol. 2014. Vol. 101–102. P. 120–126.Staff A. C., Johnsen G. M., Dechend R., Redman C. W. G. Preeclampsia and Uteroplacental Acute Atherosis: Immune and Inflammatory Factors. J Reprod Immunol. 2014. Vol. 101–102. P. 120–126.

The authors declare that there are no conflicts of interest present.