The study aims to evaluate the efficiency of therapy for chronic cystitis associated with urogenital infection in women. Materials and methods. In the course of the study, clinical and anamnestic data received from 45 women with recurrent chronic cystitis associated with urogenital cystitis was analyzed. Laboratory and instrumental tests were carried out to verify urogenital pathogens and microvasculature condition. All patients received comprehensive systemic treatment, which included antibiotic treatment, enzyme preparations, bladder instillation, epidermal laser treatment. The data was processed using Statistica 10.0 Rus software provided by the StatSoft corporation (USA). The critical level of statistical significance was equal 0.05 in validating null hypothesis. Results. Burdened gynecological anamnesis was detected in 36 (79.5 %) patients. Using polymerase chain reaction method, pathogenic and opportunistic pathogenic microorganisms in the urethra material, causing mono-infections, were found in 21 (46.5 %) women with chronic cystitis, and mix-associations of these microorganisms were foundin 24 (53.5 %) women. The elimination of pathogens was recorded in 42 (93.6 %) women in 4 weeks after receiving treatment. Prior to treatment bacteriuria and clinical symptomatology were detected in 28 (61.2 %) patients. Followingtreatment low population indicators of microflora to no microflora growth were found in 97.6 % of cases. Changes in microvasculature of bladder were characterized by congestive hemodynamic type. Relief of pain syndrome wasperformed in 95.5 % and that of dysuric syndrome – in 85.9 % of cases due to the course of therapy with epidermal laser treatment. The recovery trend of indicators of bladder microvasculature was noted positive.