surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.34822/2304-9448-2021-4-26-30surgumed-465Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНА. ОБЗОР ЛИТЕРАТУРЫCLINICAL MEDICINE. REVIEWSСОВРЕМЕННЫЕ ВОЗМОЖНОСТИ ФАРМАКОТЕРАПИИ ПАЦИЕНТОВ С СИНДРОМОМ КОРОТКОЙ КИШКИMODERN OPPORTUNITIES OF PHARMACOTHERAPY FOR PATIENTS WITH SHORT BOWEL SYNDROMEСосновскаяЕ. В.SosnovskayaE. V.

кандидат медицинских наук, доцент кафедры госпитальной терапии;

заведующая консультативно-диагностической поликлиникой,врач-гастроэнтеролог

Е-mail: evg-sosnovskaya@yandex.ru

Candidate of Sciences (Medicine), Associate Professor, Department of Hospital Therapy;

Head, Consultative and Diagnostic Hospital, Gastroenterologist

Е-mail: evg-sosnovskaya@yandex.ru

Ханты-Мансийская государственная медицинская академия; Окружная клиническая больница, Ханты-МансийскРоссияKhanty-Mansiysk State Medical Academy; District Clinical Hospital, Khanty-MansiyskRussian Federation20211612202104 (50)2630Copyright © Сосновская Е.В., 20212021Сосновская Е.В.Sosnovskaya E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/465

Цель – выявление основных методов и средств современной фармакотерапии пациентов с синдромом короткой кишки. Материал и методы. Проведен поиск научных публикаций в базах данных PubMed, eLibrary и Clinical Trials по следующим ключевым словам: кишечная недостаточность, парентеральное питание, синдром короткой кишки. Результаты. На основе анализа публикаций установлено, что аналог глюкагоноподобного пептида-2 – тедуглутид – позволяет снизить объем парентерального питания, время инфузий, а также добиться полной энтеральной автономии, что делает метод лечения этим препаратом наиболее перспективным для больных данной категории.

The study aims to detect the main methods and means for modern pharmacotherapy for patients with short bowel syndrome. Material and methods. The search was carried out in the following databases: PubMed, eLibrary, and Clinical Trials, using such keywords as intestinal failure, parental nutrition, short bowel syndrome. Results. Based on the analysis of published works, it was found that the analog of glucagonlike peptide-2, teduglutide, can reduce the parental nutrition, infusion duration, and provide full enteral autonomy, which makes the treatment method with such drug the most promising one for patients with short bowel syndrome.

кишечная недостаточностьгастроэнтерологияпарентеральное питаниесиндром короткой кишки.intestinal failuregastroenterologyparenteral nutritionshort bowel syndrome.ReferencesPironi L., Arends J., Baxter J. et al. ESPEN Endorsed Recommendations. Definition and Classification of Intestinal Failure in Adults // Clin Nutr. 2015. № 34, Is. 2. Р. 171–180. DOI 10.1016/j.clnu.2014.08.017.Pironi L., Arends J., Baxter J. et al. ESPEN Endorsed Recommendations. Definition and Classification of Intestinal Failure in Adults // Clin Nutr. 2015. № 34, Is. 2. Р. 171–180. DOI 10.1016/j.clnu.2014.08.017.Weih S., Kessler M., Fonouni H., Golriz G., Hafezi M., Mehrabi A., Holland-Cunz S. Current Practice and Future Perspectives in the Treatment of Short Bowel Syndrome in Children – A Systematic Review // Langenbecks Arch Surg. 2012. Vol. 397, Is. 7. P. 1043–1051. DOI 10.1007/s00423-011-0874-8.Weih S., Kessler M., Fonouni H., Golriz G., Hafezi M., Mehrabi A., Holland-Cunz S. Current Practice and Future Perspectives in the Treatment of Short Bowel Syndrome in Children – A Systematic Review // Langenbecks Arch Surg. 2012. Vol. 397, Is. 7. P. 1043–1051. DOI 10.1007/s00423-011-0874-8.Sulkowski J. P., Minneci P. C. Management of Short Bowel Syndrome // Pathophysiology. 2014. Vol 21, Is. 1. Р. 111–118.Sulkowski J. P., Minneci P. C. Management of Short Bowel Syndrome // Pathophysiology. 2014. Vol 21, Is. 1. Р. 111–118.McGee D. C., Gould M. K. Preventing Complications of Central Venous Catheterization // N Engl J Med. 2003. Vol. 348, Is. 12. Р. 1123–1133. DOI 10.1056/NEJMra011883.McGee D. C., Gould M. K. Preventing Complications of Central Venous Catheterization // N Engl J Med. 2003. Vol. 348, Is. 12. Р. 1123–1133. DOI 10.1056/NEJMra011883.Revestive (Teduglutide) Summary of Product Characteristics. Shire Pharmaceuticals Ireland Limited, 2019.Revestive (Teduglutide) Summary of Product Characteristics. Shire Pharmaceuticals Ireland Limited, 2019.Kocoshis S. A., Merritt R. J., Hill S. et al. Safety and Efficacy of Teduglutide in Pediatric Patients with Intestinal Failure Due to Short Bowel Syndrome: A 24-Week, Phase III Study // J Parenter Enteral Nutr. 2019. Vol. 44, Is. 4. P. 621–631. DOI 10.1002/jpen.1690.Kocoshis S. A., Merritt R. J., Hill S. et al. Safety and Efficacy of Teduglutide in Pediatric Patients with Intestinal Failure Due to Short Bowel Syndrome: A 24-Week, Phase III Study // J Parenter Enteral Nutr. 2019. Vol. 44, Is. 4. P. 621–631. DOI 10.1002/jpen.1690.Norsa L., Lambe C., Abi Abboud S. et al. The Colon as an Energy Salvage Organ for Children with Short Bowel Syndrome // Am J Clin Nutr. 2019. Vol. 109, Is. 4. P. 1112–1118. DOI 10.1093/ajcn/nqy367.Norsa L., Lambe C., Abi Abboud S. et al. The Colon as an Energy Salvage Organ for Children with Short Bowel Syndrome // Am J Clin Nutr. 2019. Vol. 109, Is. 4. P. 1112–1118. DOI 10.1093/ajcn/nqy367.Joly F., Seguy D., Nuzzo A. et al. Six-month Outcomes of Teduglutide Treatment in Adult Patients with Short Bowel Syndrome with Chronic Intestinal Failure: A Real-World French Observational Cohort Study // Clin Nutr. 2020. Vol. 39, Is. 9. P. 2856–2862. DOI 10.1016/j.clnu.2019.12.019.Joly F., Seguy D., Nuzzo A. et al. Six-month Outcomes of Teduglutide Treatment in Adult Patients with Short Bowel Syndrome with Chronic Intestinal Failure: A Real-World French Observational Cohort Study // Clin Nutr. 2020. Vol. 39, Is. 9. P. 2856–2862. DOI 10.1016/j.clnu.2019.12.019.Schwartz L. K., O’Keefe S. J. D., Fujioka K. et al. Long-term Teduglutide for the Treatment of Patients with Intestinal Failure Associated with Short Bowel Syndrome // Clin Transl Gastroenterol. 2016. Vol. 7, Is. 2. Р. e142. DOI 10.1038/ ctg.2015.69.Schwartz L. K., O’Keefe S. J. D., Fujioka K. et al. Long-term Teduglutide for the Treatment of Patients with Intestinal Failure Associated with Short Bowel Syndrome // Clin Transl Gastroenterol. 2016. Vol. 7, Is. 2. Р. e142. DOI 10.1038/ ctg.2015.69.Jeppesen P. B., Pertkiewicz M., Messing B. et al. Teduglutide Reduces Need for Parenteral Support Among Patients with Short Bowel Syndrome with Intestinal Failure // Gastroenterology. 2012. Vol. 143, Is. 6. Р. 1473–1481.e3. DOI 10.1053/j.gastro.2012.09.007.Jeppesen P. B., Pertkiewicz M., Messing B. et al. Teduglutide Reduces Need for Parenteral Support Among Patients with Short Bowel Syndrome with Intestinal Failure // Gastroenterology. 2012. Vol. 143, Is. 6. Р. 1473–1481.e3. DOI 10.1053/j.gastro.2012.09.007.Amiot A., Messing B., Corcos O., Panis A., Joly F. Determinants of Home Parenteral Nutrition Dependence and Survival of 268 Patients with Non Malignant Short Bowel Syndrome // Clin Nutr. 2013. Vol. 32, Is. 3. Р. 368–374. DOI 10.1016/j.clnu.2012.08.007.Amiot A., Messing B., Corcos O., Panis A., Joly F. Determinants of Home Parenteral Nutrition Dependence and Survival of 268 Patients with Non Malignant Short Bowel Syndrome // Clin Nutr. 2013. Vol. 32, Is. 3. Р. 368–374. DOI 10.1016/j.clnu.2012.08.007.

The authors declare that there are no conflicts of interest present.