surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.34822/2304-9448-2021-2-71-76surgumed-425Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ. ОБЗОР ЛИТЕРАТУРЫLIFE SCIENCES. REVIEWSИММУНОМОДУЛИРУЮЩИЕ ЭФФЕКТЫ ВИТАМИНА D И НОВАЯ КОРОНАВИРУСНАЯ ИНФЕКЦИЯIMMUNOMODULATORY EFFECTS OF VITAMIN D AND NOVEL CORONAVIRUS DISEASEКушниковаИ. П.KushnikovaI. P.

кандидат медицинских наук, доцент кафедры внутренних болезней, Медицинский институтЕ-mail: ira222052@mail.ru

Candidate of Sciences (Medicine), Associate Professor, Internal Diseases Department, Medical InstituteЕ-mail: ira222052@mail.ru

https://orcid.org/0000-0001-7110-442XНелидоваН. В.NelidovaN. V.

кандидат медицинских наук, доцент кафедры многопрофильной клинической подготовки, Медицинский институтЕ-mail: nelidovanv80@mail.ru

Candidate of Sciences (Medicine), Associate Professor, Multidisciplinary Clinical Education Department, Medical InstituteЕ-mail: nelidovanv80@mail.ru

Сургутский государственный университет, СургутРоссияSurgut State University, SurgutRussian Federation20210607202102 (48)7176Copyright © Кушникова И.П., Нелидова Н.В., 20212021Кушникова И.П., Нелидова Н.В.Kushnikova I.P., Nelidova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/425

Цель – осуществить обзор современной научной литературы, посвященной влиянию витамина D на иммунитет и новую коронавирусную инфекцию. Материал и методы. Проведен анализ научной литературы, представленной в базах данных PubMed, eLIBRARY и др. Глубина поиска – 10 лет. Поиск производился по следующим ключевым словам: витамин D, иммунитет, COVID-19. Результаты. Витамин D оказывает влияние на врожденный клеточный и адаптивный иммунитет. Его иммуномодулирующий эффект связан с активацией противовирусной активности, влиянием на дифференцировку Т-лимфоцитов и снижением синтеза провоспалительных цитокинов. Дефицит витамина D сопровождается снижением резистентности организма к бактериальным и вирусным заболеваниям, в том числе к новой коронавирусной инфекции. В качестве одного из перспективных направлений в профилактике и лечении COVID-19 можно рассматривать прием витамина D, который поддерживает противовирусный иммунитет и способен ослаблять «цитокиновый шторм».

The study aims to review the current evidence of the effects of vitamin D on immunity and coronavirus disease 2019 (COVID-19). Material and methods. The analysis of scientific literature sources in the databases PubMed,eLIBRARY.RU, etc. is made. The keywords used are vitamin D, immunity, and COVID-19. Results. Vitamin D affects innate cellular and acquired immunity. Its immunomodulatory effect is associated with the activation of antiviralactivity, the influence on the differentiation of T-lymphocytes, and a decrease in the synthesis of pro-inflammatory cytokines. Research confirms a clear link between low vitamin D levels and a range of infectious diseases, includingseverity and mortality from the COVID-19. One of the promising areas in the prevention and treatment of COVID-19 can be the administration of vitamin D, which supports antiviral immunity and reduces the effects of the cytokinestorm.

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The authors declare that there are no conflicts of interest present.