surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.1234/10.34822/2304-9448-2021-1-67-74surgumed-405Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ. ОБЗОР ЛИТЕРАТУРЫLIFE SCIENCES. REVIEWSОЦЕНКА ВЛИЯНИЯ ПОЛИФЕНОЛОВ И ФЛАВОНОИДОВ РАСТИТЕЛЬНОГО СЫРЬЯ НА ТЕЧЕНИЕ БЕРЕМЕННОСТИ И ЕЕ ИСХОДЫEVALUATION OF THE EFFECT OF PLANT POLYPHENOLS AND FLAVONOIDS ON THE COURSE OF PREGNANCY AND ITS OUTCOMESКоваленкоЛ. В.KovalenkoL. V.

доктор медицинских наук, профессор, заведующая кафедрой патофизиологии и общей патологии, профессор кафедры патофизиологии и общей патологии, директор Медицинского института

E-mail: lvkhome@yandex.ru

Doctor of Sciences (Medicine), Professor, Head, Department of Pathophysiology and General Pathology, Professor of the Department of Pathophysiology and General Pathology, Director, Medical Institute

E-mail: lvkhome@yandex.ru

БелоцерковцеваЛ. Д.BelotserkovtsevaL. D.

доктор медицинских наук, профессор, заведующая кафедрой акушерства, гинекологии и перинатологии, Медицинский институт;

главный врач

Е-mail: info@surgut-kpc.ru

 

Doctor of Sciences (Medicine), Professor, Head, Department of Obstetrics, Gynecology and Perinatology, Medical Institute;

Chief Medical Officer

Е-mail: info@surgut-kpc.ru

КаспароваА. Э.KasparovaA. E.

доктор медицинских наук, профессор, заведующая кафедрой акушерства и гинекологии, проректор по подготовке кадров высшей квалификации и ПДО;

профессор кафедры патофизиологии и общей патологии, Медицинский институт

Е-mail: anzkasparova@yandex.ru

Doctor of Sciences (Medicine), Professor, Head, Department of Obstetrics and Gynecology, Vice-Rector for Training Highly Qualified Personnel and Additional Professional Education;

Professor of the Department of Pathophysiology and General Pathology, Medical Institute

Е-mail: anzkasparova@yandex.ru

МордовинаИ. И.MordovinaI. I.

кандидат медицинских наук, доцент кафедры акушерства, гинекологии и перинатологии, Медицинский институт

Е-mail: mar-mariot@yandex.ru

Candidate of Sciences (Medicine), Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Medical Institute

Е-mail: mar-mariot@yandex.ru

ГуляевА. Е.GulyaevA. E.

доктор медицинских наук, профессор, научный консультант

Е-mail: akin@mail.ru

Doctor of Sciences (Medicine), Professor, Scientific Consultant

Е-mail: akin@mail.ru

КавушевскаяН. С.KavushevskayaN. S.

кандидат биологических наук, доцент кафедры патофизиологии и общей патологии, Медицинский институт

Candidate of Sciences (Biology), Associate Professor, Department of Pathophysiology and General Pathology

СинюковаТ. А.SinyukovaT. A.

научный сотрудник Научно-образовательного центра, Медицинский институт

E-mail: proles@bk.ru

Researcher, Research and Educational Center, Medical Institute

E-mail: proles@bk.ru

Сургутский государственный университет, СургутРоссияSurgut State University, SurgutRussian FederationСургутский государственный университет; Сургутский клинический перинатальный центр, СургутРоссияSurgut State University; Surgut Regional Clinical Prenatal Centre, SurgutRussian FederationХанты-Мансийская государственная медицинская академия, Ханты-Мансийск; Сургутский государственный университет, СургутРоссияKhanty-Mansiysk State Medical Academy, Khanty-Mansiysk; Surgut State University, Surgut Е-mail: anzkasparova@yandex.ruRussian FederationНациональный центр биотехнологии, Нур-СултанКазахстанNational Center for Biotechnology, Nur-Sultan,Kazakhstan20211705202101 (47)6774Copyright © Коваленко Л.В., Белоцерковцева Л.Д., Каспарова А.Э., Мордовина И.И., Гуляев А.Е., Кавушевская Н.С., Синюкова Т.А., 20212021Коваленко Л.В., Белоцерковцева Л.Д., Каспарова А.Э., Мордовина И.И., Гуляев А.Е., Кавушевская Н.С., Синюкова Т.А.Kovalenko L.V., Belotserkovtseva L.D., Kasparova A.E., Mordovina I.I., Gulyaev A.E., Kavushevskaya N.S., Sinyukova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/405

Цель – провести анализ научной литературы, посвященной изучению влияния полифенолов и флавоноидов на течение беременности и ее исходы. Материал и методы. В ходе работы проводился поиск литературы в базах данных MEDLINE, PubMed, eLIBRARY.RU и РИНЦ по следующим ключевым словам: полифенолы, флавоноиды, преэклампсия, плацентарная недостаточность, синдром задержки внутриутробного роста плода. Глубина поиска – 10 лет. Проведен анализ 120 публикаций по теме, в обзор включен 41 источник литературы. Результаты. Объем информации о безопасности этих соединений для репродуктивных процессов крайне ограничен, что свидетельствует о значительном пробеле в этой области знания и требует дополнительных исследований профиля безопасности активных полифенольных соединений в экспериментальных условиях, а также накопления и анализа данных по ситуациям из клинической практики.

The study aims to analyze the contemporary scientific literature on the influence of polyphenols and flavonoids on the course of pregnancy and its outcomes. Material and methods. In the course of the work, literature wassearched in the MEDLINE, PubMed, eLIBRARY.RU, and RSCI databases through the following keywords: polyphenols, flavonoids, preeclampsia, placental insufficiency, intrauterine growth restriction. The analysis of 120 publications was carried out. As a result, 41 literature sources were selected. The search depth was ten years. Results. Analysis of the information currently available indicates a large gap in the knowledge regarding the safety of these compounds for reproductive processes. Thus, it is necessary to conduct additional studies of the safety profile of active polyphenolic compounds in experimental conditions and it is essential to monitor the data on the situation in clinical practice.

полифенолыфлавоноидыпреэклампсиязадержка внутриутробного роста плодапре- гравидарная подготовка.polyphenolsflavonoidspreeclampsiaintrauterine growth restriction of the fetuspregravid preparation.ReferencesPérez-Jiménez J., Neveu V., Vos F. et al. Identification of the 100 Richest Dietary Sources of Polyphenols: an Application of the Phenol-Explorer Database // European Journal of Clinical Nutrition. 2010. № 64. P. 112–120.Pérez-Jiménez J., Neveu V., Vos F. et al. Identification of the 100 Richest Dietary Sources of Polyphenols: an Application of the Phenol-Explorer Database // European Journal of Clinical Nutrition. 2010. № 64. P. 112–120.Del Rio D., Rodriguez-Mateos A., Spencer J. P., Tognolini M., Borges G., Crozier A. Dietary (Poly)Phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases // Antioxid Redox Signal. 2013. No. 18. P. 1818–1892.Del Rio D., Rodriguez-Mateos A., Spencer J. P., Tognolini M., Borges G., Crozier A. Dietary (Poly)Phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases // Antioxid Redox Signal. 2013. No. 18. P. 1818–1892.Al-Gubory K. H., Fowler P. A., Garrel C. The Roles of CellularReactive Oxygen Species, Oxidative Stress and Antioxidants in Pregnancy Outcomes // The International Journal of Biochemistry & Cell Biology. 2010. No. 10. P. 1634–1650.Al-Gubory K. H., Fowler P. A., Garrel C. The Roles of CellularReactive Oxygen Species, Oxidative Stress and Antioxidants in Pregnancy Outcomes // The International Journal of Biochemistry & Cell Biology. 2010. No. 10. P. 1634–1650.Афанасьева А. А., Смирнова О. В., Ржевская Н. В., Мартюшова Е. А. Оксидативный стресс и преэклампсия // Siberian Journal of Life Sciences and Agriculture. 2019. Т. 11, № 4. С. 107.Афанасьева А. А., Смирнова О. В., Ржевская Н. В., Мартюшова Е. А. Оксидативный стресс и преэклампсия // Siberian Journal of Life Sciences and Agriculture. 2019. Т. 11, № 4. С. 107.Al-Gubory K. H. Environmental Pollutants and Lifestyle Factors induce Oxidative Stress and Poor Prenatal Development // Reprod BiomedOnline. 2014. № 29. Р. 17–31.Al-Gubory K. H. Environmental Pollutants and Lifestyle Factors induce Oxidative Stress and Poor Prenatal Development // Reprod BiomedOnline. 2014. № 29. Р. 17–31.Kaïs H., Al-Gubory K. H. Plant Polyphenols, Prenatal Development and Health Outcomes // Biol syst Open Access. 2014. Vol. 3. No. 1. Р. e110.Kaïs H., Al-Gubory K. H. Plant Polyphenols, Prenatal Development and Health Outcomes // Biol syst Open Access. 2014. Vol. 3. No. 1. Р. e110.Ly C., Yockell-Lelievre J., Ferraro Z. M., Arnason J. T., Ferrier J., Gruslin A. The Effects of Dietary Polyphenols on Reproductive Health and Early Development // Hum Reprod Update. 2015. Vol. 21. P. 228–248.Ly C., Yockell-Lelievre J., Ferraro Z. M., Arnason J. T., Ferrier J., Gruslin A. The Effects of Dietary Polyphenols on Reproductive Health and Early Development // Hum Reprod Update. 2015. Vol. 21. P. 228–248.Chen B., Tuuli M. G., Longtine M. S., Shin J. S., Lawrence R., Inder T. et al. Pomegranate Juice and Punicalagin Attenuate Oxidative Stress and Apoptosis in Human Placenta and in Human Placental Trophoblasts // American Journal of Physiology Endocrinology and Metabolism. 2012. Vol. 302, № 9. Р. e1142–1152.Chen B., Tuuli M. G., Longtine M. S., Shin J. S., Lawrence R., Inder T. et al. Pomegranate Juice and Punicalagin Attenuate Oxidative Stress and Apoptosis in Human Placenta and in Human Placental Trophoblasts // American Journal of Physiology Endocrinology and Metabolism. 2012. Vol. 302, № 9. Р. e1142–1152.Mozaffari H., Daneshzad E., Surkan P. J., Azadbakht L. Dietary Total Antioxidant Capacity and Cardiovascular Disease Risk Factors: a Systematic Review of Observational Studies // Journal of the American College of Nutrition. 2018. Vol. 37, № 6. P. 533–545.Mozaffari H., Daneshzad E., Surkan P. J., Azadbakht L. Dietary Total Antioxidant Capacity and Cardiovascular Disease Risk Factors: a Systematic Review of Observational Studies // Journal of the American College of Nutrition. 2018. Vol. 37, № 6. P. 533–545.Kim K., Vance T. M., Chun O. K. Greater Total Antioxidant Capacity from Diet and Supplements is Associated with a Less Atherogenic Blood Profile in U.S. Adults // Nutrients. 2016. Vol. 8, № 1. P. 15.Kim K., Vance T. M., Chun O. K. Greater Total Antioxidant Capacity from Diet and Supplements is Associated with a Less Atherogenic Blood Profile in U.S. Adults // Nutrients. 2016. Vol. 8, № 1. P. 15.Psaltopoulou T., Panagiotakos D. B., Pitsavos C. et al. Dietary Antioxidant Capacity is Inversely Associated with Diabetes Biomarkers: the ATTICA Study // Nutrition, Metabolism, and Cardiovascular Diseases. 2011. Vol. 21, № 8. P. 561–567.Psaltopoulou T., Panagiotakos D. B., Pitsavos C. et al. Dietary Antioxidant Capacity is Inversely Associated with Diabetes Biomarkers: the ATTICA Study // Nutrition, Metabolism, and Cardiovascular Diseases. 2011. Vol. 21, № 8. P. 561–567.Matthews L. G., Smyser C. D., Cherkerzian S. et al. MaternalMatthews L. G., Smyser C. D., Cherkerzian S. et al. MaternalPomegranate Juice Intake and Brain Structure and Function in Infants with Intrauterine Growth Restriction: A Randomized Controlled Pilot Study // PLOS ONE. 2019. Vol. 14, № 8. Р. e0219596.Pomegranate Juice Intake and Brain Structure and Function in Infants with Intrauterine Growth Restriction: A Randomized Controlled Pilot Study // PLOS ONE. 2019. Vol. 14, № 8. Р. e0219596.Jauniaux E.; Burton G. J. The Role of Oxidative Stress in Placental-Related Diseases of Pregnancy // J Gynecol Obstet Biol Reprod (Paris). 2016. Vol. 45, № 8. Р. 775–785.Jauniaux E.; Burton G. J. The Role of Oxidative Stress in Placental-Related Diseases of Pregnancy // J Gynecol Obstet Biol Reprod (Paris). 2016. Vol. 45, № 8. Р. 775–785.Parkinson L.; Cicerale S. The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds // Molecules. 2016. Vol. 21, № 12. P. 1734.Parkinson L.; Cicerale S. The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds // Molecules. 2016. Vol. 21, № 12. P. 1734.Garcia-Contreras C., Vazquez-Gomez M., Barbero A. et al. Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype // International Journal of MolecularGarcia-Contreras C., Vazquez-Gomez M., Barbero A. et al. Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype // International Journal of MolecularSciences. 2019. Vol. 20, № 5. P. 1187.Sciences. 2019. Vol. 20, № 5. P. 1187.Finn-Sell S. L., Cottrell E. C., Greenwood S. L. et al. Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS/ Mouse Model of Fetal Growth Restriction // Front Physiol.Finn-Sell S. L., Cottrell E. C., Greenwood S. L. et al. Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS/ Mouse Model of Fetal Growth Restriction // Front Physiol.№ 9. P. 1145.№ 9. P. 1145.Kallela K., Heinonen K., Saloniemi H. Plant Oestrogens; the Cause of Decreased Fertility in Cows. A Case Report // Nord Vet Med. 1984. Vol. 36. P. 124–129.Kallela K., Heinonen K., Saloniemi H. Plant Oestrogens; the Cause of Decreased Fertility in Cows. A Case Report // Nord Vet Med. 1984. Vol. 36. P. 124–129.Mustonen E., Taponen S., Andersson M., Sukura A., Katila T., Taponen J. Fertility and Growth of Nulliparous Ewes after Feeding Red Clover Silage with High Phyto-Oestrogen Concentrations // Animal. 2014. № 8. P. 1699–1705.Mustonen E., Taponen S., Andersson M., Sukura A., Katila T., Taponen J. Fertility and Growth of Nulliparous Ewes after Feeding Red Clover Silage with High Phyto-Oestrogen Concentrations // Animal. 2014. № 8. P. 1699–1705.Hashem N. M., El-Azrak K. M., Nour El-Din A. N. M., Sallam S. M., Taha T. A., Salem M. H. Effects of Trifolium Alexandrinum Phytoestrogens on Oestrous Behaviour, Ovarian Activity and Reproductive Performance of Ewes during the Non-Breeding Season // Anim Reprod Sci. 2018.Hashem N. M., El-Azrak K. M., Nour El-Din A. N. M., Sallam S. M., Taha T. A., Salem M. H. Effects of Trifolium Alexandrinum Phytoestrogens on Oestrous Behaviour, Ovarian Activity and Reproductive Performance of Ewes during the Non-Breeding Season // Anim Reprod Sci. 2018.Vol. 196. P. 1–8.Vol. 196. P. 1–8.Zielinsky P., Busato S. Prenatal Effects of Maternal Consumption of Polyphenol-Rich Foods in Late Pregnancy upon Fetal Ductus Arteriosus // Birth Defects Res. C Embryo Today. 2013. Vol. 99, № 4. P. 256–274.Zielinsky P., Busato S. Prenatal Effects of Maternal Consumption of Polyphenol-Rich Foods in Late Pregnancy upon Fetal Ductus Arteriosus // Birth Defects Res. C Embryo Today. 2013. Vol. 99, № 4. P. 256–274.Vian I., Zielinsky P., Zílio A. M., Schaun M. I. et al. Increase of Prostaglandin E2 in the Reversal of Fetal Ductal Constriction after Polyphenol Restriction // Ultrasound Obstet Gynecol. 2018. Vol. 52, № 5. P. 617–622.Vian I., Zielinsky P., Zílio A. M., Schaun M. I. et al. Increase of Prostaglandin E2 in the Reversal of Fetal Ductal Constriction after Polyphenol Restriction // Ultrasound Obstet Gynecol. 2018. Vol. 52, № 5. P. 617–622.Abdel Mohsen A. H., Amin A. S. Risk Factors and Outcomes of Persistent Pulmonary Hypertension of the Newborn in Neonatal Intensive Care Unit of Al-minya University Hospital in Egypt // Journal of Clinical Neonatology. 2013. Vol. 2. P. 78–82.Abdel Mohsen A. H., Amin A. S. Risk Factors and Outcomes of Persistent Pulmonary Hypertension of the Newborn in Neonatal Intensive Care Unit of Al-minya University Hospital in Egypt // Journal of Clinical Neonatology. 2013. Vol. 2. P. 78–82.Simpson J., Zidere V., Miller O. I. Fetal Cardiology: A PracticalSimpson J., Zidere V., Miller O. I. Fetal Cardiology: A PracticalApproach to Diagnosis and Management. Springer International Publishing, 2018. 308 p.Approach to Diagnosis and Management. Springer International Publishing, 2018. 308 p.American Diabetes Association. Classification and Diagnosis of Diabetes // Diabetes Care. 2020. № 43. Р. s14–s31.American Diabetes Association. Classification and Diagnosis of Diabetes // Diabetes Care. 2020. № 43. Р. s14–s31.Noctor E., Crowe C., Carmody L. A. et al. ATLANTIC-DIP: Prevalence of Metabolic Syndrome and Insulin Resistance in Women with Previous Gestational Diabetes Mellitus by International Association of Diabetes in Pregnancy Study Groups criteria // Acta Diabetologica. 2015 Vol. 52, No. 1.Noctor E., Crowe C., Carmody L. A. et al. ATLANTIC-DIP: Prevalence of Metabolic Syndrome and Insulin Resistance in Women with Previous Gestational Diabetes Mellitus by International Association of Diabetes in Pregnancy Study Groups criteria // Acta Diabetologica. 2015 Vol. 52, No. 1.P. 153–160.P. 153–160.Al-Shebly M. M., Mansour M. A. Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor // Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012. 6 p.Al-Shebly M. M., Mansour M. A. Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor // Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012. 6 p.Daneshzad E., Tehrani H., Bellissimo N, Azadbakht L. DietaryDaneshzad E., Tehrani H., Bellissimo N, Azadbakht L. DietaryTotal Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study // Oxid Med Cell Longev. 2020. Vol. 2020. 9 p.Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study // Oxid Med Cell Longev. 2020. Vol. 2020. 9 p.Andrade de B. М., Crivellenti L. C., Zuccolotto D. C. C., Franco L. J., Sartorelli D. S. The Relationship of Flavonoid Intake during Pregnancy with Excess Body Weight and Gestational Diabetes Mellitus // Arch Endocrinol Metab. 2019. Vol. 63, № 3. P. 241–249.Andrade de B. М., Crivellenti L. C., Zuccolotto D. C. C., Franco L. J., Sartorelli D. S. The Relationship of Flavonoid Intake during Pregnancy with Excess Body Weight and Gestational Diabetes Mellitus // Arch Endocrinol Metab. 2019. Vol. 63, № 3. P. 241–249.Wang Y.-Y., Liu Y., Li C., Lin J., Liu X., Sheng J.-Z., Huang H.- F.Wang Y.-Y., Liu Y., Li C., Lin J., Liu X., Sheng J.-Z., Huang H.- F.Frequency and Risk Factors for Recurrent Gestational Diabetes Mellitus in Primiparous Women: A Case Control Study // BMC Endocr Disord. 2019. Vol. 19. P. 1–7.Frequency and Risk Factors for Recurrent Gestational Diabetes Mellitus in Primiparous Women: A Case Control Study // BMC Endocr Disord. 2019. Vol. 19. P. 1–7.Rahman M. S., Mujahid M. D., Siddiqui M. A., Rahman M. S., Arif M., Eram S., Khan A., Azeemuddin M. D. Ethnobotanical Uses, Phytochemistry and Pharmacological Activities of Pterocarpus Marsupium: A Review // Pharmacog J. 2018. Vol. 10, № 6. Р. s1–s8.Rahman M. S., Mujahid M. D., Siddiqui M. A., Rahman M. S., Arif M., Eram S., Khan A., Azeemuddin M. D. Ethnobotanical Uses, Phytochemistry and Pharmacological Activities of Pterocarpus Marsupium: A Review // Pharmacog J. 2018. Vol. 10, № 6. Р. s1–s8.Sun Y. L., Zhou F. M., Wang H. R. Mechanism of pomegranat Ellagic Polyphenols Reducing Insulin Resistance on Gestational Diabetes Mellitus Rats // Am J Transl Res. 2019. Vol. 11, № 9. P. 5487–5500.Sun Y. L., Zhou F. M., Wang H. R. Mechanism of pomegranat Ellagic Polyphenols Reducing Insulin Resistance on Gestational Diabetes Mellitus Rats // Am J Transl Res. 2019. Vol. 11, № 9. P. 5487–5500.Pham N. M., Do V. V., Lee A. H. Polyphenol-rich Foods and Risk of Gestational Diabetes: A Systematic Review and Meta-Analysis // European Journal of Clinical Nutrition. 2019. Vol. 73 № 5. P. 647–656.Pham N. M., Do V. V., Lee A. H. Polyphenol-rich Foods and Risk of Gestational Diabetes: A Systematic Review and Meta-Analysis // European Journal of Clinical Nutrition. 2019. Vol. 73 № 5. P. 647–656.Pistollato F., Battino M. Role of Plant Based Diets in the Prevention and Regression of Metabolic Syndrome and Neurodegenerative Diseases // Trends Food Sci Technol. 2014. Vol. 40. P. 62–81.Pistollato F., Battino M. Role of Plant Based Diets in the Prevention and Regression of Metabolic Syndrome and Neurodegenerative Diseases // Trends Food Sci Technol. 2014. Vol. 40. P. 62–81.Craig W. J., Mangels A. R. American Dietetic Association. Position of the American Dietetic Association: Vegetarian Diets // J Am Diet Assoc. 2009. Vol. 109. P. 1266–82.Craig W. J., Mangels A. R. American Dietetic Association. Position of the American Dietetic Association: Vegetarian Diets // J Am Diet Assoc. 2009. Vol. 109. P. 1266–82.Pretorius R. A., Palmer D. J. High-Fiber Diet during Pregnancy Characterized by More Fruit and Vegetable Consumption // Nutrients. 2021. Vol. 13, № 1. P. 35.Pretorius R. A., Palmer D. J. High-Fiber Diet during Pregnancy Characterized by More Fruit and Vegetable Consumption // Nutrients. 2021. Vol. 13, № 1. P. 35.Melina V., Craig W., Levin S. Position of the Academy of Nutrition and Dietetics: Vegetarian Diets // Journal of the Academy of Nutrition and Dietetics. 2016. Vol. 116, № 12. P. 1970–1980.Melina V., Craig W., Levin S. Position of the Academy of Nutrition and Dietetics: Vegetarian Diets // Journal of the Academy of Nutrition and Dietetics. 2016. Vol. 116, № 12. P. 1970–1980.Piccoli G. B., Clari R., Vigotti F. et al. Vegan-vegetarian Diets in Pregnancy: Danger or Panacea? A Systematic Narrative Review // BJOG. 2015. Vol. 122, № 5. P. 623–633.Piccoli G. B., Clari R., Vigotti F. et al. Vegan-vegetarian Diets in Pregnancy: Danger or Panacea? A Systematic Narrative Review // BJOG. 2015. Vol. 122, № 5. P. 623–633.Rigacci S., Stefani M. Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans // Int J Mol Sci. 2016. Vol. 17. P. 843.Rigacci S., Stefani M. Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans // Int J Mol Sci. 2016. Vol. 17. P. 843.Filardi T., Varì R., Ferretti E., Zicari A., Morano S., Santangelo C. Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications? // Nutrients. 2020. Vol. 12, № 10. P. 3179.Filardi T., Varì R., Ferretti E., Zicari A., Morano S., Santangelo C. Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications? // Nutrients. 2020. Vol. 12, № 10. P. 3179.Li S., Chen M., Li Y., Tollefsbol T. O. Prenatal Epigenetics Diets Play Protective Roles Against Environmental Pollution // Clinical Epigenetics. 2019. Vol. 11, № 1. P. 82Li S., Chen M., Li Y., Tollefsbol T. O. Prenatal Epigenetics Diets Play Protective Roles Against Environmental Pollution // Clinical Epigenetics. 2019. Vol. 11, № 1. P. 82Alafiatayo A. A., Lai K.-S., Syahida A., Maziah M., Shaharudin N. Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio) // Evid.-Based Complementary Altern Med. 2019. Vol. 2019. 10 p.Alafiatayo A. A., Lai K.-S., Syahida A., Maziah M., Shaharudin N. Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio) // Evid.-Based Complementary Altern Med. 2019. Vol. 2019. 10 p.

The authors declare that there are no conflicts of interest present.