surgumedВестник СурГУ. МедицинаVestnik SurGU. Meditsina2949-3447Сургутский государственный университет10.34822/2304-9448-2020-3-62-68surgumed-354Research ArticleМЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ. ОБЗОР ЛИТЕРАТУРЫLIFE SCIENCES. REVIEWSПЛАЗМА КРОВИ, ОБОГАЩЕННАЯ ТРОМБОЦИТАМИ: ТЕХНОЛОГИЯ, МЕХАНИЗМ ДЕЙСТВИЯ ПРИ АНДРОГЕНЕТИЧЕСКОЙ АЛОПЕЦИИPLATELET-RICH PLASMA: TECHNOLOGY, MECHANISM OF ACTION IN ANDROGENETIC ALOPECIAhttps://orcid.org/0000-0001-7758-3935ХалирахмановА. Ф.KhalirakhmanovA. F.

кандидат медицинских наук, врач по рентгенэндоваскулярной диагностике и лечению,

старший преподаватель кафедры хирургии, акушерства и гинекологии

Е-mail: ai.bolit@mail.ru

 

 

Candidate of Sciences (Medicine), Physician in Endovascular Diagnostics and Treatment,

Senior Lecturer, Department of Surgery, Obstetrics, and Gynecology

Е-mail: ai.bolit@mail.ru

https://orcid.org/0000-0003-2997-0644ИдрисоваК. Ф.IdrisovaK. F.

лаборант-исследователь

Е-mail: idrisovakam@mail.ru

 

Clinical Research Assistant;

Е-mail: idrisovakam@mail.ru

https://orcid.org/0000-0002-4181-5818АбдрахмановА. Р.AbdrakhmanovA. R.

кандидат медицинских наук, врач-дерматовенеролог, руководительтерапевтического направления, заместитель главного врача по медицинской части,

научный сотрудник

Е-mail: dr.abdrakhmanov.azat@yandex.ru

Candidate of Sciences (Medicine), Dermatovenerologist, Head, Therapeutic Department, Deputy Chief Medical Officer for Treatment, Researcher

Е-mail: dr.abdrakhmanov.azat@yandex.ru

 

 

Университетская клиника (Медико-санитарная часть Казанского федерального университета), Казань, Казанский (Приволжский) федеральный университет, КазаньРоссияUniclinic KFU, Kazan, Kazan (Volga Region) Federal University, KazanRussian FederationУниверситетская клиника (Медико-санитарная часть Казанского федерального университета), Казань Казанский (Приволжский) федеральный университет, КазаньРоссияUniclinic KFU, Kazan, Kazan (Volga Region) Federal University, KazanRussian Federation20200110202003 (45)6268Copyright © Халирахманов А.Ф., Идрисова К.Ф., Абдрахманов А.Р., 20202020Халирахманов А.Ф., Идрисова К.Ф., Абдрахманов А.Р.Khalirakhmanov A.F., Idrisova K.F., Abdrakhmanov A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surgumed.ru/jour/article/view/354выпадение волосандрогенетическая алопециятрансплантация волособогащенная тромбоцитами плазмаPRP-терапияhair lossandrogenetic alopeciahair transplantationplatelet-rich plasmaPRP therapyReferencesAlves R., Grimalt R. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification // Ski Appendage Disord. 2018. № 4 (1). P. 18–24.Alves R., Grimalt R. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification // Ski Appendage Disord. 2018. № 4 (1). P. 18–24.Amgar G., Bouhanna P. Platelet Rich Plasma: a Therapy for Hair Growth // Prime Journal. 2013. P. 20–31.Amgar G., Bouhanna P. Platelet Rich Plasma: a Therapy for Hair Growth // Prime Journal. 2013. P. 20–31.Mubki T. Platelet-Rich Plasma Combined with Intralesional Triamcinolone Acetonide for the Treatment of Alopecia Areata: A Case Report // J Dermatology Dermatologic Surg. 2016. № 20. P. 87–90.Mubki T. Platelet-Rich Plasma Combined with Intralesional Triamcinolone Acetonide for the Treatment of Alopecia Areata: A Case Report // J Dermatology Dermatologic Surg. 2016. № 20. P. 87–90.Stevens J., Khetarpal S. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol // International Journal of Women’s Dermatology. 2018. № 5 (1). P. 46–51.Stevens J., Khetarpal S. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol // International Journal of Women’s Dermatology. 2018. № 5 (1). P. 46–51.Gentile P., Cole J. P., Cole M. A., Garcovich S., Bielli A., Scioli M. G., Orlandi A., Insalaco C., Cervelli V. Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems // International Journal of Molecular Sciences. 2017. № 18 (2). P. 408.Gentile P., Cole J. P., Cole M. A., Garcovich S., Bielli A., Scioli M. G., Orlandi A., Insalaco C., Cervelli V. Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems // International Journal of Molecular Sciences. 2017. № 18 (2). P. 408.Marx R. E. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? // Implant Dent. 2001. № 10. P. 225–228.Marx R. E. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? // Implant Dent. 2001. № 10. P. 225–228.Weibrich G., Kleis W. K., Hafner G., Hitzler W. E. Growth Factor Levels in Platelet-Rich Plasma and Correlations with Donor Age, Sex, and Platelet Count // Journal of Cranio-Maxillofacial Surgery. 2002. № 30 (2). P. 97–102.Weibrich G., Kleis W. K., Hafner G., Hitzler W. E. Growth Factor Levels in Platelet-Rich Plasma and Correlations with Donor Age, Sex, and Platelet Count // Journal of Cranio-Maxillofacial Surgery. 2002. № 30 (2). P. 97–102.Zhu Y., Yuan M., Meng H. Y., Wang A. Y., Guo Q. Y., Wang Y., Peng J. Basic Science and Clinical Application of Platelet-Rich Plasma for Cartilage Defects and Osteoarthritis: A Review // Osteoarthritis and Cartilage. 2013. № 21 (11). P. 1627–1637.Zhu Y., Yuan M., Meng H. Y., Wang A. Y., Guo Q. Y., Wang Y., Peng J. Basic Science and Clinical Application of Platelet-Rich Plasma for Cartilage Defects and Osteoarthritis: A Review // Osteoarthritis and Cartilage. 2013. № 21 (11). P. 1627–1637.Toyoda T., Isobe K., Tsujino T., Koyata Y., Ohyagi F., Watanabe T., Nakamura M., Kitamura Y., Okudera H., Nakata K., Kawase T. Direct Activation of Platelets by Addition of CaCl 2 Leads Coagulation of Platelet-Rich Plasma // International Journal of Implant Dentistry. 2018. № 4 (1). P. 23.Toyoda T., Isobe K., Tsujino T., Koyata Y., Ohyagi F., Watanabe T., Nakamura M., Kitamura Y., Okudera H., Nakata K., Kawase T. Direct Activation of Platelets by Addition of CaCl 2 Leads Coagulation of Platelet-Rich Plasma // International Journal of Implant Dentistry. 2018. № 4 (1). P. 23.Sudnik W., Dańczak-Pazdrowska A., Silny W., Osmola-Mańkowska A., Pazdrowski J., Polańska A. The Role of Selectins in Alopecia Areata. Advances in Dermatology and Allergology // Postepy Dermatologii i Alergologii. 2015. № 32 (1). P. 27.Sudnik W., Dańczak-Pazdrowska A., Silny W., Osmola-Mańkowska A., Pazdrowski J., Polańska A. The Role of Selectins in Alopecia Areata. Advances in Dermatology and Allergology // Postepy Dermatologii i Alergologii. 2015. № 32 (1). P. 27.Wang E., McElwee K. J. Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It? // Dermatologic Therapy. 2011. № 24 (3). P. 337–347.Wang E., McElwee K. J. Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It? // Dermatologic Therapy. 2011. № 24 (3). P. 337–347.Erdem T, AktaÅŸ A. N., Yildirim A. Increased Serum Level of P-Selectin in Patients with Lichen Planus // Yonsei Medical Journal. 2004. № 45 (2). P. 215–218.Erdem T, AktaÅŸ A. N., Yildirim A. Increased Serum Level of P-Selectin in Patients with Lichen Planus // Yonsei Medical Journal. 2004. № 45 (2). P. 215–218.Pamuk G. E., Nuri O. P., Orüm H., Arican O., Turgut B., Demir M. Elevated Platelet-Monocyte Complexes in Patients with Psoriatic Arthritis // Platelets. 2009. № 20 (7). P. 493–497.Pamuk G. E., Nuri O. P., Orüm H., Arican O., Turgut B., Demir M. Elevated Platelet-Monocyte Complexes in Patients with Psoriatic Arthritis // Platelets. 2009. № 20 (7). P. 493–497.Morris R. J., Liu Y., Marles L., Yang Z., Trempus C., Li S., Lin J. S., Sawicki J. A., Cotsarelis G. Capturing and Profiling Adult Hair Follicle Stem Cells // Nature Biotechnology. 2004. № 22 (4). P. 411–417.Morris R. J., Liu Y., Marles L., Yang Z., Trempus C., Li S., Lin J. S., Sawicki J. A., Cotsarelis G. Capturing and Profiling Adult Hair Follicle Stem Cells // Nature Biotechnology. 2004. № 22 (4). P. 411–417.Cervelli V., Garcovich S., Bielli A., Cervelli G., Curcio B.C., Scioli M. G., Orlandi A., Gentile P. The Effect of Autologous Activated Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation // BioMed Research International. 2014. № 4. P. 1–9.Cervelli V., Garcovich S., Bielli A., Cervelli G., Curcio B.C., Scioli M. G., Orlandi A., Gentile P. The Effect of Autologous Activated Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation // BioMed Research International. 2014. № 4. P. 1–9.Lichtenberger B. M., Mastrogiannaki M., Watt F. M. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signalling to Distinct Fibroblast Lineages // Nature Communications. 2016. № 7 (1). P. 1–3.Lichtenberger B. M., Mastrogiannaki M., Watt F. M. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signalling to Distinct Fibroblast Lineages // Nature Communications. 2016. № 7 (1). P. 1–3.Greco J., Brandt R. The Effects of Autologus Platelet Rich Plasma and Various Growth Factors on Non-transplanted Miniaturized Hair // Hair Transplant Forum International. 2009. P. 49–50.Greco J., Brandt R. The Effects of Autologus Platelet Rich Plasma and Various Growth Factors on Non-transplanted Miniaturized Hair // Hair Transplant Forum International. 2009. P. 49–50.Gentile P., Garcovich S. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development // Cells. 2019. № 8. P. 466.Gentile P., Garcovich S. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development // Cells. 2019. № 8. P. 466.Li W., Enomoto M., Ukegawa M., Hirai T., Sotome S., Wakabayashi Y., Shinomiya K., Okawa A. Subcutaneous Injections of Platelet-Rich Plasma into Skin Flaps Modulate Proangiogenic Gene Expression and Improve Survival Rates // Plastic and Reconstructive Surgery. 2012. № 129 (4). P. 858–866.Li W., Enomoto M., Ukegawa M., Hirai T., Sotome S., Wakabayashi Y., Shinomiya K., Okawa A. Subcutaneous Injections of Platelet-Rich Plasma into Skin Flaps Modulate Proangiogenic Gene Expression and Improve Survival Rates // Plastic and Reconstructive Surgery. 2012. № 129 (4). P. 858–866.Yang J., Zhao S., Yang X., Zhang H., Zheng P., Wu H. Inhibition of Bcell Apoptosis is Mediated Through Increased Expression of Bcl‐2 in Patients with Rheumatoid Arthritis // International Journal of Rheumatic Diseases. 2016. № 19 (2). P. 134–140.Yang J., Zhao S., Yang X., Zhang H., Zheng P., Wu H. Inhibition of Bcell Apoptosis is Mediated Through Increased Expression of Bcl‐2 in Patients with Rheumatoid Arthritis // International Journal of Rheumatic Diseases. 2016. № 19 (2). P. 134–140.Leo M. S., Kumar A. S., Kirit R., Konathan R., Sivamani R. K. Systematic Review of the Use of Platelet‐Rich Plasma in Aesthetic Dermatology // Journal of Cosmetic Dermatology. 2015. № 14 (4). P. 315–323.Leo M. S., Kumar A. S., Kirit R., Konathan R., Sivamani R. K. Systematic Review of the Use of Platelet‐Rich Plasma in Aesthetic Dermatology // Journal of Cosmetic Dermatology. 2015. № 14 (4). P. 315–323.Asadi M., Alamdari D. H., Rahimi H. R., Aliakbarian M., Jangjoo A., Abdollahi A., Bahar M. M., Azadmand A., Forghani N., Sadegh M. N., Khayamy M. E. Treatment of Life-Threatening Wounds with a Combination of Allogenic Platelet-Rich Plasma, Fibrin Glue and Collagen Matrix, and a Literature Review // Experimental and Therapeutic Medicine. 2014. № 8 (2). P. 423–429.Asadi M., Alamdari D. H., Rahimi H. R., Aliakbarian M., Jangjoo A., Abdollahi A., Bahar M. M., Azadmand A., Forghani N., Sadegh M. N., Khayamy M. E. Treatment of Life-Threatening Wounds with a Combination of Allogenic Platelet-Rich Plasma, Fibrin Glue and Collagen Matrix, and a Literature Review // Experimental and Therapeutic Medicine. 2014. № 8 (2). P. 423–429.Halaban R., Langdon R., Birchall N., Cuono C., Baird A., Scott G., Moellmann G., McGuire J. Basic Fibroblast Growth Factor from Human Keratinocytes is a Natural Mitogen for Melanocytes // The Journal of Cell Biology. 1988. № 107 (4). P. 1611–1619.Halaban R., Langdon R., Birchall N., Cuono C., Baird A., Scott G., Moellmann G., McGuire J. Basic Fibroblast Growth Factor from Human Keratinocytes is a Natural Mitogen for Melanocytes // The Journal of Cell Biology. 1988. № 107 (4). P. 1611–1619.Matsumoto K., Hashimoto K., Hashiro M., Yoshimasa H., Yoshikawa K. Modulation of Growth and Differentiation in Normal Human Keratinocytes by Transforming Growth Factor‐β // Journal of Cellular Physiology. 1990. № 145 (1). P. 95–101.Matsumoto K., Hashimoto K., Hashiro M., Yoshimasa H., Yoshikawa K. Modulation of Growth and Differentiation in Normal Human Keratinocytes by Transforming Growth Factor‐β // Journal of Cellular Physiology. 1990. № 145 (1). P. 95–101.Sorbellini E., Trink A., Rinaldi F. Experimental Clinical Assessment of the Use of Platelet-Rich Plasma in Dermatology and Rationale for its Use in the Treatment of Non-Scarring Alopecia // La Medicina Estetica. 2011. № 35 (4).Sorbellini E., Trink A., Rinaldi F. Experimental Clinical Assessment of the Use of Platelet-Rich Plasma in Dermatology and Rationale for its Use in the Treatment of Non-Scarring Alopecia // La Medicina Estetica. 2011. № 35 (4).Takikawa M., Nakamura S., Nakamura S., Ishirara M., Kishimoto S., Sasaki K., Yanagibayashi S., Azuma R., Yamamoto N., Kiyosawa T. Enhanced Effect of Platelet‐Rich Plasma Containing a New Carrier on Hair Growth // Dermatologic Surgery. 2011. № 37 (12). P. 1721–1729.Takikawa M., Nakamura S., Nakamura S., Ishirara M., Kishimoto S., Sasaki K., Yanagibayashi S., Azuma R., Yamamoto N., Kiyosawa T. Enhanced Effect of Platelet‐Rich Plasma Containing a New Carrier on Hair Growth // Dermatologic Surgery. 2011. № 37 (12). P. 1721–1729.Uebel C. O., da Silva J. B., Cantarelli D., Martins P. The role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery // Plastic and Reconstructive Surgery. 2006. № 118 (6). P. 1458–1466.Uebel C. O., da Silva J. B., Cantarelli D., Martins P. The role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery // Plastic and Reconstructive Surgery. 2006. № 118 (6). P. 1458–1466.Gobbi A., Karnatzikos G., Mahajan V., Malchira S. Platelet-rich Plasma Treatment in Symptomatic Patients with Knee Osteoarthritis: Preliminary Results in a Group of Active Patients // Sports Health. 2012. № 4 (2). P. 162–172.Gobbi A., Karnatzikos G., Mahajan V., Malchira S. Platelet-rich Plasma Treatment in Symptomatic Patients with Knee Osteoarthritis: Preliminary Results in a Group of Active Patients // Sports Health. 2012. № 4 (2). P. 162–172.Oh J. H., Kim W. O., Park K. U., Roh Y. H. Comparison of the Cellular Composition and Cytokine-Release Kinetics of Various Platelet-Rich Plasma Preparations // The American Journal of Sports Medicine. 2015. № 43 (12). P. 3062–3070.Oh J. H., Kim W. O., Park K. U., Roh Y. H. Comparison of the Cellular Composition and Cytokine-Release Kinetics of Various Platelet-Rich Plasma Preparations // The American Journal of Sports Medicine. 2015. № 43 (12). P. 3062–3070.Gkini M. A., Kouskoukis A. E., Tripsianis G., Rigopoulos D., Kouskoukis K. Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through an One-Year Period // Journal of Cutaneous and Aesthetic Surgery. 2014. № 7 (4). P. 213.Gkini M. A., Kouskoukis A. E., Tripsianis G., Rigopoulos D., Kouskoukis K. Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through an One-Year Period // Journal of Cutaneous and Aesthetic Surgery. 2014. № 7 (4). P. 213.Gentile P., Garcovich S., Scioli M. G., Bielli A., Orlandi A., Cervelli V. Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia // JoVE (Journal of Visualized Experiments). 2018. № 27 (131). P. e56406.Gentile P., Garcovich S., Scioli M. G., Bielli A., Orlandi A., Cervelli V. Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia // JoVE (Journal of Visualized Experiments). 2018. № 27 (131). P. e56406.Hamberg M., Svensson J., Samuelsson B. Thromboxanes: a New Group of Biologically Active Compounds Derived from Prostaglandin Endoperoxides // Proc Natl Acad Sci. 1975. № 72. P. 2994–2998.Hamberg M., Svensson J., Samuelsson B. Thromboxanes: a New Group of Biologically Active Compounds Derived from Prostaglandin Endoperoxides // Proc Natl Acad Sci. 1975. № 72. P. 2994–2998.Giordano S., Romeo M., Lankinen P. Platelet-rich Plasma forGiordano S., Romeo M., Lankinen P. Platelet-rich Plasma forAndrogenetic Alopecia: Does it Work? Evidence from Meta Analysis // J Cosmet Dermatol. 2017. № 16. P. 374–381.Androgenetic Alopecia: Does it Work? Evidence from Meta Analysis // J Cosmet Dermatol. 2017. № 16. P. 374–381.

The authors declare that there are no conflicts of interest present.