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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">surgumed</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник СурГУ. Медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Vestnik SurGU. Meditsina</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2949-3447</issn><publisher><publisher-name>Сургутский государственный университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1234/10.34822/2304-9448-2019-4-74-78</article-id><article-id custom-type="elpub" pub-id-type="custom">surgumed-259</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ. ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LIFE SCIENCES. REVIEWS</subject></subj-group></article-categories><title-group><article-title>ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ ПОЛИГЕННОГО ИНДЕКСА РИСКА (PRS) ДЛЯ ОЦЕНКИ РИСКА РАЗВИТИЯ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ</article-title><trans-title-group xml:lang="en"><trans-title>PROSPECTS OF APPLYING THE POLYGENIC RISK SCORES (PRS) TO ESTIMATE THE RISK OF BREAST CANCER DEVELOPMENT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6620-2770</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>магистр</p><p>e-mail: smirnova10nv@gmail.com</p></bio><bio xml:lang="en"><p>Master of Science</p><p>e-mail: smirnova10nv@gmail.com</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9768-8574</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елмуратов</surname><given-names>А. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Elmuratov</surname><given-names>A. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник</p><p>e-mail: artem@genotek.ru</p><p>Author ID в РИНЦ: 928632</p></bio><bio xml:lang="en"><p>Researcher</p><p>e-mail: artem@genotek.ru</p><p>RSCI ID: 928632</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московская государственная академия тонкой химической технологии им. М. В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State Academy of Fine Chemical Technology named after M. V. Lomonosov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт биомедицинской химии имени В. Н. Ореховича, г. Москва; ООО «Генотек» », г. Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biomedical Chemistry, Moscow; Genotek LLC, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>4 (42)</issue><fpage>74</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смирнова Н.В., Елмуратов А.У., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Смирнова Н.В., Елмуратов А.У.</copyright-holder><copyright-holder xml:lang="en">Smirnova N.V., Elmuratov A.U.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surgumed.ru/jour/article/view/259">https://www.surgumed.ru/jour/article/view/259</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>полногеномный поиск ассоциаций</kwd><kwd>рак молочной железы</kwd><kwd>полигенный индекс риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>genome-wide association study (GWAS)</kwd><kwd>breast cancer</kwd><kwd>polygenic risk score</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">International Agency for Research on Cancer, Cancer Today, Pie chart. 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